Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"granulosa cell"”.
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Molecular Studies on Pathogenesis, Prognostic Factors, and New Treatment Options for Ovarian Granulosa Cell Tumors
Granulosa cell tumor (GCT) is the second most common subtype of ovarian cancer, representing 5% of all ovarian malignancies. GCTs are characterized by an indolent course of disease, with a 5-year survival rate of over 90%. However, recurrences occur in 20-30% of patients, also those with …
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Role and regulation of prostaglandin production in granulosa cell DNA synthesis during ovarian follicular development.
… in the mitogenic actions of TGF$\alpha$ on granulosa cells during follicular development, as well as its involvement in the regulation of urokinase plasminogen activator, an enzyme playing an important role in tissue remodelling. Granulosa cells from the first (F1), fifth, and sixth (F5-6) …
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Stress Fiber Formation and Migration Are Novel PGR-Dependent Pathways Initiated in the Granulosa Cells of the Ovulating Follicle
… For ovulation to be successful, a series of intercellular events must be spatially and temporally coordinated throughout the ovarian follicle, culminating in rupture at the follicle apex and subsequent oocyte release. The nuclear steroid receptor, progesterone receptor (PGR) is a master-regulator …
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Extraovarian and Intraovarian Control of Follicular Selection in the Chicken Ovary
… (EGF), an intraovarian hormone, suppresses granulosa cell differentiation. However, the precise regulation and interactions of these hormones on follicular selection and the expression of their receptors have not been determined. The objectives of this study we (1) develop and validate a …
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Morphogenesis and Female Fate Determination in Vertebrates
… which is made by a population of somatic cells known as the bipotential supporting cell precursors, determines whether an embryo will develop as a phenotypic male or female. Though several molecular pathways have been shown to be required for female fate determination in vertebrates, the …
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Improving the development of bovine in vitro produced embryos cultured individually
… replacer and a co-culture with bovine granulosa cells were applied to individually cultured embryos in a 3x2 design. None of the interventions was found to be significantly different from the others, and all resulted in significantly lower development than embryos cultured as a group …
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Ire1 regulates cyp11a1 transcription to mediate steroidogenesis in the ovary
… an ER stress response is not induced in KGN cells by forskolin treatment. We hypothesize that IRE1 is necessary to mediate CYP11A1 transcription in response to forskolin, a gonadotropin mimetic, in a mechanism independent to its role in ER stress. In the human KGN granulosa cell line, IRE1 is …
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EFFECTS OF CANNABIS CONSTITUENTS ON OVARIAN HEALTH AND FUNCTION: A FOCUS ON PRENATAL EXPOSURE
… of folliculogenesis, angiogenesis, and granulosa cell proliferation and apoptosis. Reduced vascularization in THC-exposed ovaries was also associated with decreased expression of the angiogenic factor vascular endothelial growth factor (VEGF) and its receptor (VEGFR-2), as well as …
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Investigating the role of ephrins and their receptors in mouse folliculogenesis and ovulation
Follicle stimulating hormone (FSH) promotes granulosa cell (GC) proliferation, differentiation, and steroidogenesis. This series of events is critical for female fertility, and culminates in the formation of mature follicles responsive to the surge of luteinizing hormone (LH) that triggers …
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Strategies to Improve Reproductive Efficiency in Cattle with Dietary Intervention
… associated plasma protein A gene expression in granulosa cells. The experimental group that received the diet greater in starch exhibited a greater concentration of plasma IGF-1, greater number of large follicles on the dates that insemination would occur in a TAI situation, and a lower amount …
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PGE2 Receptor Subsets Mediate HCG Regulation of the Plasminogen Activator/Plasmin System in Primate Periovulatory Follicles
… are present in monkey periovulatory follicles, granulosa cells and whole ovaries were collected 0, 12, 24, and 36 hours after administration of an ovulatory dose of human chorionic gonadotropin (hCG), or 36 hours after hCG from monkeys that received the prostaglandin (PG) synthesis inhibitor …
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The role of endothelin-2 in ovulation
… ovulation, the oocyte and associated cumulus cells are expelled from the ovary and travel to the ampulla of the oviduct where fertilization occurs. Concurrently, granulosa and theca cells of an ovulating follicle luteinize and form lutein cells of the highly vascular corpus luteum, which …
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Mechanism of Bisphenol A toxicity in adult mouse ovarian antral follicles
… undergo atresia, a normal process of follicular cell death. Disturbances in follicle growth or atresia could impair healthy oocyte development and ovulation, ultimately affecting fertility. Steroidogenesis is required for healthy development and functioning of various physiological systems such …
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The role of the Fused toes locus containing Iroquois homeobox gene 3, 5, and 6 and Ftm, Fto, and Fts during ovary and testis development in mice
… absence of the the Ft locus, the primordial germ cells (PGC) develop normally, however, many PGC fail to migrate to the genital ridge and fail to proliferate once they reach the genital ridge. Failure of the PGC migration and proliferation causes a significant reduction in the number of germ …
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EFFECT OF CONSTITUTIVELY ACTIVATED LUTEINIZING HORMONE RECEPTOR ON THE MOUSE REPRODUCTIVE SYSTEM
… for the Doctor of Philosophy degree in Molecular Cellular and Systemic Physiology, presented on 11th December, 2015 at Southern Illinois University Carbondale. TITLE: EFFECT OF CONSTITUTIVELY ACTIVATED LUTEINIZING HORMONE RECEPTOR ON THE MOUSE REPRODUCTIVE SYSTEM MAJOR PROFESSOR: Dr. Prema Narayan …
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PROSTAGLANDIN E2 PATHWAY AS A TARGET TO PREVENT AND TREAT OVARIAN CANCER IN LAYING HENS
… expression patterns. COX-1 is expressed in most cells and tissues and remains constant under most physiologic conditions to play a housekeeping role whereas the COX-2 form is inducible and usually only expressed in response to various inflammatory stimuli. COX enzymes may be involved in both …
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The serum concentrations of anti-Mullerian hormone (AMH), thyroid-stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) during early pregnancy
… with exogenous gonadotrophins, detection of granulosa cell tumours and identification of premature ovarian insufficiency. AMH also influences follicle growth, but the precise mechanism by which it does this is unknown and its role during pregnancy has not been adequately characterised. In …
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MORPHOLOGICAL FEATURES OF THE REPRODUCTIVE ORGANS IN DOMESTIC SPECIES IN RELATION TO WATER MOVEMENT CONTROL, HYPONUTRITION AND ENVIRONMENTAL INFLUENCES IN FETAL AND PREPUBERTAL LIFE, AND METABOLISM REGULATOR FACTORS.
… membrane proteins that are able to make the cell membrane 10 to 100 fold more permeable than the membranes lacking such channels. Based on studies with AQP1, it appears that AQPs exist in the plasma membrane as homotetramers. Each AQP monomer contains 2 hemi-pores, which fold together to form …