Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"granulocytes"”.
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Antigenic Determinants on the Surface of Granulocytes of Battella Germanica
… when compared to that of the mammalian system. Granulocytes are a basic blood cell type found in most animals; in humans these cells divide and differentiate into basophils, eosinophils, and neutrophils, among others. These cells make up a small portion of the total blood cells found in mammals. …
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The expression of potential molecular candidates for chloride ion channels in primary human granulocytes and granulocytic cell lines
… candidates for chloride (Cl-) ion channels in granulocytes, and granulocytic cell lines. It is hypothesised that Cl- ion channels, in particular hBest1, are implicated in the role of granulocytes in response to inflammation. METHODOLOGY: Two main methodologies were used; laboratory techniques …
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Investigation of the immunological differences between granulocytes from healthy donors and breast cancer patients, with respect to the cancer testis antigen, CTCFL
Granulocytes or Polymorphonuclear neutrophils (PMNs) are key players in the non-specific immune system against microbial infection as they express surface receptors for the recognition of general antigenic patterns found on pathogens. In addition PMN’s also act as a mediator for the …
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Characterization of Hemocytes in Amblyomma americanum and Investigation of TRAF6’s Role in Proliferation of Hemocytes in Response to Infection
… identified: prohemocytes, plasmatocytes, type-I granulocytes, and type-II granulocytes. To elucidate molecular processes, we investigated AamTRAF as an immune-related gene by silencing the gene using RNAi then quantifying the hemocytes after inoculation with gram-negative and positive bacteria. …
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Antibiotics and human phagocytic cells
… These studies showed that phagocytosis by human granulocytes is rapid (T-§- = 5.6 minutes), but subsequent intracellular killing is much slower. In a cell-free system different antibiotics had variable rates of bacterial inactivation but, in general, these rates were of the same order as the rate …
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Autophagy mechanisms in sputum and peripheral blood cells of patients with severe asthma: a new therapeutic target
… Objective: We compared autophagy in the sputum granulocytes, peripheral blood cells (PBCs), and peripheral blood eosinophils (PBEs) between patients with severe asthma and those with non-severe asthma and investigated the functional effects of autophagy. Methods: We enrolled 36 patients with …
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C/EBPalpha downregualtes c-jun expression
… C/EBPa is crucial for the differentiation of granulocytes. Conditional expression of C/EBPa triggers neutrophilic differentiation and C/EBPa can block TPA induced monocytic differentiation of bipotential myeloid cells. In C/EBPa knockout mice, no mature granulocytes are present. A dramatic …
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Determinants of innate immune responses to mycobacteria
… monocytes, myeloid dendritic cells and granulocytes recognise mycobacteria and initiate immune responses such as phagocytosis, cytokine production and expression of maturation markers. The type and magnitude of innate responses to mycobacteria may determine the subsequent adaptive …
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Leukocyte Response to Elastin-Like Polypeptide Coatings
… ELP1 = 63.1 ± 17.1 %, ELP4 = 61.8 ± 16.8 %; granulocytes: ELP1 = 62.7 ± 17.0 %, ELP4 = 60.5 ± 20.1 %) were both decreased compared to uncoated MylarTM, while CD11b upregulation (monocytes: ELP1 = 18.7 ± 2.2 %, ELP4 = 19.7 ± 2.7 %; granulocytes: ELP = 21.4 ± 3.7 %, ELP4 = 22.0 ± 3.2 %) was …
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ΠΥΡΕΤΙΚΑ ΕΠΕΙΣΟΔΙΑ ΣΕ ΛΕΥΚΟΠΕΝΙΚΟΥΣ ΑΣΘΕΝΕΙΣ: ΣΥΓΚΡΙΣΗ ΤΗΣ ΑΠΟΤΕΛΕΣΜΑΤΙΚΟΤΗΤΑΣ ΤΩΝ ΣΥΝΔΥΑΣΜΩΝ ΚΑΡΜΠΕΝΙΚΙΛΛΙΝΗΣ/ΓΕΝΤΑΜΙΚΙΝΗΣ ΚΑΙ ΑΖΛΟΚΙΛΛΙΝΗΣ/ΚΕΦΟΞΙΤΙΝΗΣ
… TRIAL 66 FEBRILE GRANULOCYTOPENIC PATIENTS (GRANULOCYTES < 1000/MM^3) WERE GIVEN EITHER CARBENICILLIN (C) 30 GR/DAY PLUS GENTAMICIN (G) 4-5 GR/KGR/DAY OR AZLOCILLIN (A) 20 GR/DAY PLUS CEFOXITIN (F) 8 GR/DAY.THE OVERALL SUCCESSFUL RESPONSE RATE WAS 46,66% FOR C/G AND 70,3% FOR A/F, ASSOCIATED …
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Mechanisms of Immuno-Modulation With The TLR4 Agonist Monophosphoryl Lipid A in the Treatment of Sepsis
… Treatment with MPLA increased the numbers of granulocytes, undifferentiated myeloid cells, and macrophages at infection sites. MPLA treatment also increased the percentage and total numbers of myeloid cells mediating phagocytosis of bacteria. Depletion of monocytes did not eliminate the …
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The Ecological Ramifications of Disease and Density in the Caribbean Spiny Lobster, <i>Panulirus argus</i>
… lobsters, specifically the hyalinocytes and semi-granulocytes, but not the granulocytes. When hemolymph from infected donors was injected into healthy juvenile lobsters, 90% of the healthy individuals became infected within 80 days. In another set of laboratory trials, 40% of the juvenile lobsters …
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Gene Repression and Cell Cycle Regulation by PU.1 in Acute Myeloid Leukemia
… types of the immune system, including B cells, granulocytes, and monocytes. Mutation of the gene encoding PU.1, SPI1 in humans and Sfpi1 in mice, is associated with AML. We hypothesized that reduced expression of PU.1 in Sfpi1BN/BNmyeloid cells will result in the development of AML in …
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Characterisation of protease activated receptors
… vein endothelial cells, keratinocytes and granulocytes. The expression of both PAR-2 and thrombin receptor were analysed using Northern analysis in a wide variety of murine haematopoietic cell lines. This analysis revealed the widespread distribution of the thrombin receptor. In contrast …
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Wirkung von Enterococcus faecium auf den Organismus neonataler Hundewelpen
… higher count on lymphocytes, neutrophil granulocytes and monocytes. Ec. faecium feeding resulted possibly in a raised number of macrophages, and herewith monocytes, a stronger immune response with more lymphocytes and a higher phagocytotic activity of neutrophil granulocytes. The lower …
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Describing the immune cell profile of ventricular cerebrospinal fluid (CSF) in paediatric central nervous system (CNS) infections
… immune cells (CD45+: lymphocytes, monocytes and granulocytes) and CNS-derived immune cells (microglia (CD45-TMEM119+) and astrocytes (CD45-ACSA+) were examined along with their respective sub-groups. The sample supernatants were batch analysed for inflammatory biomarkers including interleukin …
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Studio dei tratti immunofenotipici e valutazione del loro contributo nell'insorgenza di patologie
… in peripheral blood including monocytes, granulocytes, circulating dendritic cells and lymphocytes divided in NK, B and T cell subsets. Immunophenotypes, assessed by flow cytometry, were initially measured in 1,629 volunteers,belonging to the SardiNIA project, who have been genotipically …
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Development and application of monoclonal antibodies in studies of the human leukotriene B4 receptor, BLT1
… acid derivate that attracts e.g. monocytes and granulocytes to inflammatory sites and induces phagocytosis and degranulation. LTB4 binds to BLT1 which is a 7-transmembrane receptor that belongs to the superfamily of G protein-coupled receptors (GPCRs). BLT1 and LTB4 are not only important in …
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Host response in sepsis
… amazing! For example cells, such as neutrophil granulocytes, produce antibiotic substances (antimicrobial peptides, AMPs). Increased knowledge of the host response in sepsis will aid in refining and developing new treatment. We investigated the effect of the AMP, LL-37, on smooth muscle activity …
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Impact of Temperature and Microbial Infection on the Honey Bee Hemocytes
… dropped sharply, particularly in CLD/LP groups. Granulocytes (phagocytosis) and plasmatocytes (encapsulation) were most affected. Notably, 22°C alone stressed healthy bees but was catastrophic for CLD-treated individuals.</p> <p>Discussion</p> <p>Hemocytes are essential for stress resilience. …
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