Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 74 for “"granulocyte"”.
-
Mevalonate metabolites contribute to granulocyte chemotaxis, cytokine production, and sepsis mortality
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
-
Controlling Pseudomonas aeruginosa Persister Cells by Human Granulocyte Macrophage Colony-Stimulating Factor
… cells.</p> <p>In this study, we focused on granulocyte macrophage colony-stimulating factor (GM-CSF), a cytokine produced by macrophages, T-cells, endothelial cells, and fibroblasts. We chose Pseudomonas aeruginosa as a model bacterium. It is an opportunistic pathogenic bacterium and a major …
-
The role of complement and granulocyte colony stimulating factor in ANCA associated vasculitis
Hieutrophil cytoplasmic antibody (ANCA) associated vasculitis is a systemic disease i affects the kidneys, lungs, and other tissues. ANCA were first described in patients i focal necrotising glomerulonephritis in 1982, with myeloperoxidase )) and proteinase 3 (PR3) subsequently shown to be the …
-
Cytokine engineering through ligand/receptor dynamics : a study on granulocyte colony-simulating factor
Granulocyte colony-stimulating factor (GCSF) is a cytokine of great clinical importance, with application to elevate neutrophil counts in cancer patients undergoing chemotherapy. GCSF binds to its specific receptor (GCSFR) on bone marrow precursor cells and generates intracellular signals that …
-
Monocytic Cells Mediate Granulocyte-Colony Stimulating Factor-Induced Mobilization of Hematopoietic Stem and Progenitor Cells
… through a process known as mobilization. Granulocyte-colony stimulating factor: G-CSF), a hematopoietic growth factor, is the most widely-used mobilizing agent clinically. However, the mechanisms by which G-CSF elicits HSPC mobilization are not well-understood. The experiments described …
-
Granulocyte Colony-Stimulating Factor Minimizes Negative Remodeling of Decellularized Small Diameter Vascular Graft Conduits but Not Medial Degeneration
… study was aimed to investigate the influence of granulocyte colony-stimulating factor (G-CSF) on inhibiting adverse remodeling of decellularized SDVCs. METHODS: Sprague-Dawley rats implanted with allograft infra renal abdominal aortic conduits were divided into 2 groups according to whether they …
-
Experimental infection with Sarcocystis neurona alters the immune response: the effect on CD4+, CD8+, B-cell, monocyte and granulocyte populations in horses
Previous studies have demonstrated differences in CD4+, CD8+ and B-cell populations between EPM affected and normal horses. The overall goal of our project was to further define the immune deficiencies associated with S. neurona infection. We hypothesized that PMA/I stimulated suppression in EPM …
-
Transcriptional regulation of the GM-CSF gene in T lymphocytes / Cameron Stuart Osborne.
… the investigation as to whether the mouse granulocyte-macrophage colony-stimulating factor and interleukin-3 genes are regulated in a similar manner as those of the human, focussing on regulation through an enhancer.
-
Gene expression profiling of patients with Polycythaemia Rubra Vera using cDNA microarrays
… to wild-type littermates with respect to granulocyte counts and different factors involved in iron homeostasis. Overexpression of the PRV-1 mRNA, decreased c-Mpl protein levels on platelets and the formation of EECs are laboratory findings which can be used for differential diagnosis among …
-
Engineering scaffold and soluble cues for cell-instruction
… injectable depot for the controlled release of granulocyte colony stimulating factor in porcine models. Although the hydrogel system was only tested with bovine serum albumin and granulocyte colony stimulating factor, we expect this customizable and user-friendly platform to be readily applied …
-
Antigenic Determinants on the Surface of Granulocytes of Battella Germanica
… when compared to that of the mammalian system. Granulocytes are a basic blood cell type found in most animals; in humans these cells divide and differentiate into basophils, eosinophils, and neutrophils, among others. These cells make up a small portion of the total blood cells found in mammals. …
-
Immunomodulatory effects of lactic acid bacteria on human intestinal epithelial cells and macrophages in the context of a pro-inflammatory challenge
… α was assayed by ELISA for interleukin-8 (IL-8). Granulocyte-macrophage colony stimulating factor (GM-CSF) production was assayed by ELISA in the HT-29 cell line. Strain-dependent differences were observed in the ability of viable bacteria and spent de Mann-Rogosa- Sharpe (MRS) broths from log …
-
Relationship of General and Health-related Anxiety and Worry to Markers of Inflammation in Women with Advanced Cancer
… IL-2, IL-4, IL-6, IL-10, IL-12, IFN-¿¿, TNF-¿¿, Granulocyte Macrophage Colony Stimulating Factor, Vascular Endothelial Growth Factor). Results indicated anxiety was positively related to humoral inflammatory markers, IL-4, while worry was positively related to IL-4 and showed a quadratic …
-
Mechanistic studies on chemical instabilities of recombinant proteins
… methionine residues in a model protein G-CSF (Granulocyte-Colony Stimulating Factor) was studied to address the issue of how protein structure affects its reactivity. Comparative oxidation studies were performed where the kinetics of oxidation of methionine residues by hydrogen peroxide (H₂0₂) …
-
Ras signaling enhances the activity of C/EBPalpha to induce granulocytic differentiation by phosphorylation of serine 248
… factor C/EBPa regulates early steps of normal granulocyte differentiation since mice with a disruption of the C/EBPa gene do not express detectable levels of the G-CSF receptor and produce no neutrophils. We have recently shown that C/EBPa function is also impaired in acute myeloid leukemias. …
-
Mathematical modeling of molecular mechanisms governing cell cycle progression in Caulobacter crescentus and differentiation of immune system progenitor cells
… mechanism that drives cell fate determination in granulocyte-monocyte progenitor (GMP) cells that are exposed to various cytokines. By converting this molecular mechanism into a set of ordinary differential equations (ODEs), we acquired new insights into the behavior of differentiating GMP cells. …
-
Neuroprotective Molecules and Strategies in a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
… the efficacy of interferon beta (IFNβ), granulocyte-colony stimulating factor (G-CSF), and osteopontin (OPN) in reducing apoptosis and inflammation following neonatal hypoxic ischemic encephalopathy and have outlined the cellular pathways involved in their abilities to provide …
-
Characterisation of cytokine secretion in malignant gliomas
… follistatin, fibroblast growth factor (FGF), granulocyte – colony stimulating factor (G-CSF), soluble human epidermal growth factor receptor 2 neural (sHER2neu), soluble interleukin-6 receptor alpha (sIL-6R alpha), platelet-derived growth factor - AABB (PDGF-AABB), platelet and endothelial …
Page 1 of 4