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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 342 for “"granules"”.
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Biochemical Properties of Leucocyte Granules
Made available in DSpace on 2014-12-09T14:36:53Z (GMT). No. of bitstreams: 1 6604327.pdf: 2660289 bytes, checksum: 7740d9eabbc35a4da94b933f4cfbbfef (MD5) Previous issue date: 1965
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Cell-Free Formation of RNA Granules
… through transport and sequestration by RNA granules. RNA granules are large, non-membrane bound ribonucleoparticles that have been observed in various biological contexts. Unfortunately, because RNA granules are highly heterogeneous and weakly associating aggregates, they can be difficult to …
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Factors affecting drug distribution in granules.
… affecting the distribution of a low dose drug in granules prepared by the massing and screening method have been investigated. Five granule formulations were used to elucidate the effect of the "relative solubilities" on the drug distribution in granules. These were borax/lactose, sodium …
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Porous calcium phosphate granules for biomedical applications
… of bone graft, in the form of calcium phosphate granules, has been developed by using the droplet extrusion technique. The granules were characterized chemically and physically, with specific attention to in vivo and in vitro analyses. The proposed method has allowed us to obtain spherical …
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Microfluidic assembly and packing dynamics of colloidal granules
… Many methods exist for producing colloidal granules, including fluidized granulation, high shear mixer granulation, and spray drying. However, none of these methods provide adequate control over these important parameters. In this thesis, we use microfluidic-based assembly methods to control …
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The convective melting and coalescence of polymer granules
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, 1978
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Altered Morphology And Composition Of Zymogen Granules In Acute Pancreatitis
… membrane bound secretory vesicles called Zymogen Granules (ZG), and activated extracellularly. In acute pancreatitis however, the digestive enzymes are prematurely activated within the cell, resulting in autodigestion of the tissue. Pancreatitis is a gastrointestinal disorder in which there are …
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Characterizing unique features of prion-like domains recruited to stress granules
… where localization to stress granules is modulated by differences in residue composition of the domains. To measure the different degrees of assembly propensity of PrLDs, we developed a novel means of quantitative image analysis to determine the enrichment of PrLDs in stress …
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A Comparative Study of Azure Granules Under Normal and Pathological Conditions
University of Minnesota Masters thesis. May 1920. Major: Anatomy. 1 computer file (PDF); 37 pages.
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STRESS GRANULES MODULATE SYK TO CAUSE MICROGLIAL DYSFUNCTION IN ALZHEIMER’S DISEASE
… lab indicates that SYK can associate with stress granules, ribonucleoprotein particles that form in stressed cells and contain inactive translation initiation complexes. I found that microglial cell lines and primary mouse brain microglia, when stressed by exposure to sodium arsenite or Aβ(1-42) …
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Sam68, Stress Granules, and translational control of HIV-1 nef mRNA
… to form a macromolecular structure called stress granules (SG). In addition, we demonstrated that these variants bound to nef mRNA in a sequence-specific manner. Furthermore, we showed that these variants co-localized with nef mRNA in SG. Importantly, we validated these findings in the context of …
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Comparison of the Protein Contents of Bovine Zymogen Granules and of Pancreatic Juice
… protein, about 95%. The protein content of the granules has been solubilized by exposure to pH 8, after which a membrane fraction could be isolated by centrifugation. This fraction is assumed to represent the smooth surfaced membranes which bound in situ the zymogen granules. The proteins …
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Platelet Dense Granules Mature Within Late Stages Of Megakaryocyte Differentiation By Cargo Delivery
Platelet dense granules (DGs) are storage organelles for calcium ions, small organic molecules such as ADP and serotonin, and larger polyphosphates that are secreted upon platelet stimulation to enhance platelet activation, adhesion, and stabilization at sites of vascular damage. However, the …
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Parallels and Divergences in Multisystem Proteinopathy Genes: Stress Granules, Autophagy, and Myogenic Deficits
… we examined three areas of interest: stress granules, autophagy, and myogenesis. The currently identified roster of MSP genes have several structural and functional commonalities which fall into two categories: LC3B-intracting domain containing autophagy adaptors (SQSTM1, VCP, OPTN) and …
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Role of Syk in the regulation of cytoskeleton and stress granules in breast cancer
… partners also found to be recruited to stress granules. Treatment of cells with inducers of stress granule formation leads to the recruitment of Syk to these protein-RNA complexes. This recruitment requires the phosphorylation of Syk on tyrosine and results in the phosphorylation of proteins at …
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The role of Nbeal2 in the homeostasis and retention of granules in haematopoietic cells
… primarily characterised by the absence of α-granules in platelets. Typical clinical features of GPS include macrothrombocytopenia, abnormal or excessive bleeding, splenomegaly, and bone marrow fibrosis. GPS is caused by biallelic mutations in the NBEAL2 gene, where the deficiency of platelet …
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The impact of stress history of deformable dry granules on the mechanical properties of tablets
… in the dry granulation literature, milled granules that are polydisperse in solid fraction, size, and shape are extensively used for compaction studies. Thus, the effect of an individual granule property or an individual component on the compaction properties of dry granules was not …
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