Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"granule cells"”.
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Death, survival, and morphological development of hippocampal granule cells born in an inflammatory environment
The brain continues to form new neurons throughout life. This process of adult neurogenesis has been thoroughly documented in several species including birds, rodents and humans. Adult neurogenesis is not a global process, but is confined to two subcompartments of the brain; the subventricular zone …
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On the transmission properties of synapses made between granule cells and cerebellar Purkinje cells
… The ascending axon (AA) segment of the granule cell axon forms synapses with PCs as well as the PF segment. PPF and fluctuation analysis of EPSCs in rat PCs confirmed that the release sites of AA synapses have a greater probability of transmitter release than PF synapses. Furthermore, AA …
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Paradoxically Sparse Chemosensory Tuning in Broadly-Integrating External Granule Cells in the Mouse Accessory Olfactory Bulb
The file named "ZHANG-PRIMARY-2022-1.pdf" is the primary dissertation file. Seven (7) supplemental video files are also available and may be viewed individually.
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The study of sonic hedgehog signaling pathway in the development of lysosomal acid phosphatase (Acp2) mutant mice cerebellar granule cells
… cortex defect with a significant reduction in granule cells in the cerebellum. The sonic hedgehog (SHH) and N-Myc pathways are important for granule cell precursor proliferation and differentiation. The project tests the hypothesis that the proliferation defect of granule cells is associated …
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The Impact of Opioids and Opiates on Adult Hippocampal Neurogenesis
… proliferation and survival of progenitor cells in the adult rat and mouse hippocampus. Here, I show that endogenous opioids may act through the mu opioid receptor (MOR) to similarly decrease survival of new hippocampal neurons. An exon 1 MOR knockout mouse showed increased survival of new …
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Aberrant assembly and function of a hippocampal circuit in a genetic mouse model of schizophrenia
… and decreases in the excitability of mature granule cells. Moreover, the dentate gyrus is one of two regions in the brain where adult neurogenesis occurs and this process is believed to be important for encoding new memories. Disc1Tm1Kara mutant mice have a 20% reduction in neurogenesis and …
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Retroviral envelope glycoproteins: mediators of neuropathology in nervous system development and neurodegeneration in HIV-1 infection
… epilepsy. In this study, we exposed cultured cells of the dentate gyrus (granule cells) and hippocampal gyrus (pyramidal cells) to gpl20 to assess their relative sensitivity to its neurotoxicity. Granule cells were resistant to concentrations of gpl20 which produce significant cell death …
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Molecular mechanisms of neuronal homoeostasis in vivo
… measure the change in electrical properties of granule cells in the dentate gyrus and pyramidal cells in CA1 caused by expression of Kir2.1. I show that the excitability of neurones expressing Kir2.1 was reduced compared to control neurones. By 2 weeks after virus injection the neurones showed …
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Ena/VASP proteins regulate vertebrate nervous system development : a thesis presented
… the motility and morphology of a variety of cells. I have investigated the in vivo requirement for the vertebrate family members, Mena and VASP in nervous system development. I show that Mena and VASP are required for viability and the formation of the neural tube, spinal nerves and several …
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Protein Phosphatase Inhibitor-1 and Cdk5: Of Molecules and Memory
… to identify electrical properties of dentate granule cells that might be affected by Cdk5-dependent phosphorylation of inhibitor-1. Most promising among the results was a reduction in the ability of granule cells lacking inhibitor-1 to faithfully respond to high-frequency trains of stimuli. …
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Deconvoluting Cell-Type Specific 3'UTR Isoform Expression in the Adult and Developing Cerebellum
… in alternative polyadenylation between granule and Purkinje cells in the mouse cerebellum, as well as between proliferating and adult granule cells. Interestingly, among transcripts that differed in alternative polyadenylation in both these comparisons, many were involved in key neuronal …
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Tracking The Flow of Information Through The Hippocampal Formation In The Rat
… The principal cell of the dentate gyrus, the granule cell, has spatially selective place fields; however, the behavioral correlates of another excitatory cell, the mossy cell of the dentate polymorphic layer, are unknown. This report shows that putative mossy cells have spatially selective …
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Effetto della separazione materna sulla plasticità dei neuroni nell’ippocampo delle mamme e della prole
… spines and arborization of the dendritic tree in granule cells of hippocampus. Another goal of our study is to verify on the offspring, if stress induced by insufficient maternal care in the first 15 days of life increases the vulnerability to chronic stress conditions in adulthood. In this …
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Investigating Experience-Dependent Plasticity in the Accessory Olfactory Bulb
… inhibition at reciprocal synapses between mitral cells (MCs) and local interneurons. The mechanisms underlying these changes remain controversial. Moreover, it remains unclear whether MC-interneuron plasticity is unique to specific behaviors, such as mating, or whether it is a more general feature …
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A Map of Transcription Factor Expression in Neuronal Precursors of the Chicken and Mouse Embryonic Cerebellum
… neurons, the Purkinje cell (PC) and the granule cell (GC), whereas the CN are formed by an heterogeneous array of cerebellar nuclei neurons. Although granule cell development is well-studied, the specification and early migratory routes of cerebellar nuclei neurons and Purkinje cells are …
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Investigating the role of cell-autonomous ROS status in the regulation of hippocampal neural precursor cells in adult mice
… a continued recruitment of neural precursor cells (NPCs) into active cell cycle and their progressive transition into post-mitotic granule cells. These adult born neurons integrate into the existing circuitry and confer structural plasticity, which aids in key hippocampal functions. For …
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Investigation of Accessory Olfactory Interneuron Physiology and Function After Experience-Dependent Plasticity
… In the AOB, interneurons called internal granule cells (IGCs) express the plasticity-associated immediate-early gene Arc following intermale aggression or mating. Here, I sought to understand how Arc-expressing IGCs shape AOB information processing and social behavior in the context of …
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Spatial-Temporal Regulation of the Atonal Homolog 1 Gene
… for the correct development of the cerebellar granule cells, the dorsal interneuron 1 population, gut goblet cells and the cochlear and vestibular hair cells of mice. The purpose of these studies was to determine how atonal homolog 1 is regulated by analyzing the activity of atonal homolog 1 …
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ZIPRO1: Fine Tuning Proliferation in Discrete Cell Populations
… of expression in several tissues. The main cells expressing Zipro1 are proliferating cells from epidermal lineages. This includes the cerebellar granule cells (GCs), nasal epithelia and dermal papilla. Through gene dosage experiments we have shown that Zipro1 is involved in proliferation …
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Characterization and Functional Analysis of Astrotactin 2 Reveals a Role for Endocytosis in Glial-guided Neuronal Migration
… principal neurons of the cerebellar circuitry, granule cells and Purkinje cells, develops by glial-guided migrations that position these cell types in specific neuronal layers. Classical EM studies and real time imaging of the migration of granule neurons along glial fibers established the mode …
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