Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 98 for “"granulation"”.
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Biological nutrients eradication employing Aerobic Granulation
… an insight of an emerging biotechnology: Aerobic Granulation, for its suitability to remove phosphorus (growth limiting nutrient) and nitrogen existing in domestic wastewater. The research focuses on investigation of different mechanisms supporting domestic level phosphorus removal in aerobic …
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Studies on the fluidised bed granulation process.
… is an evaluation of the process of fluidised bed granulation with the objectives of elucidating the mechanism of granule formation and identifying the fundamental parameters affecting granule quality thereby enabling the true benefits of the process to be realised. Initially the effect of seven …
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MULTI-SCALE MODELING OF HIGH-SHEAR GRANULATION
High shear wet granulation is a particle design process used to increase the size of a primary powder material through the addition of liquid binder. This thesis focuses on the multi-scale nature of high-shear granulation in order to understand behavior changes due to coupled consolidation and …
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Regime map development for co-rotating twin screw granulation
Continuous granulation is an important process for the future PAT (Processes analytical technology) initiative for the FDA. Therefore it is important to investigate the relationship between operating conditions and the granules. This thesis focused on one of the main equipments – twin screw …
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Mechanical dispersion of semi-solid binders in high-shear granulation
<p>Granulation is an important industrial process used to produce many foods, medicines, consumer products, and industrial intermediate products. This thesis focuses on high shear wet granulation with the specific case study of detergent manufacture using a high shear pin mixer. The key rate …
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Modeling and Control of Batch Pulsed Top-spray Fluidized bed Granulation
… study of the batch top-spray fluidized bed granulation was carried out including experimental study, population balance model (PBM), computational fluid dynamic (CFD) study and control strategy development. For the experimental study, the influence variables of pulsed frequency, binder spray …
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Nutrient (Ammonium and Phosphate) Removal Using Aerobic Granulation at Pilot scale
This research investigated the causes of aerobic granulation inhibition and deterioration in nutrient removal performance of aerobic granular sludge (AGS) reactors at pilot scale. Identifying the underlying phenomena seems necessary to enhance predictability and reliability of this process under …
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A detailed, stochastic population balance model for twin-screw wet granulation
… population balance model for twin-screw granulation using the stochastic weighted particle method. A number of new particle mechanisms are introduced and existing mechanisms augmented including immersion nucleation, coagulation, breakage, consolidation, liquid penetration, primary …
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Advanced Biofilm and Aerobic Granulation Technologies for Water and Wastewater Treatment
… flow system. Therefore, continuous flow aerobic granulation from traditional activated sludge was investigated and, for the first time, successfully achieved in continuous flow plug-flow bioreactors fed with real municipal wastewater. Besides, the role and critical value of an essential …
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Optimisation of granola breakfast cereal manufacturing process by wet granulation and pneumatic conveying
… breakfast cereal manufacturing processes by wet granulation and pneumatic conveying. Granola is an aggregated food product used as a breakfast cereal and in cereal bars. Processing of granola involves mixing the dry ingredients (typically oats, nuts, etc.) followed by the addition of a binder …
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The use of roller compaction as granulation method for hydrophilic extended release matrix tablets
… work evaluated the use of roller compaction as granulation method for hydroxypropyl methylcellulose (HPMC) based hydrophilic extended release matrix tablets. Roller compaction is a dry granulation method where powder material is fed through a hopper between two counter-rotating rolls and pressed …
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GRANULATION OF ULTRA-FINE POWDERS: EXAMINATION OF GRANULE MICROSTRUCTURE, CONSOLIDATION BEHAVIOR, AND POWDER FEEDING
… B. Ph.D., Purdue University, December 2015. Granulation Behavior of Ultra-Fine Powders: Examination of Granule Microstructure, Consolidation Behavior, and Powder Feeding. Major Professor: James Litster
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Evaluation of Granulation Processes in Upflow Anaerobic Sludge Blanket Reactors Using Oligonucleotide Probe Hybridizations
… syntrophic consortia to serve as nuclei for granulation were evaluated by monitoring granulation processes starting from non-granular sludge in two laboratory-scale upflow anaerobic sludge blanket reactors (Reactor G and Reactor GP). New probes for Methanosaeta spp. and Syntrophobacter spp. …
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Effect of a wet granulation manufacturing process on the stability of a pharmaceutical drug product
This thesis deals with the application of thermal analysis techniques to understand the root cause of low assay results observed during stability testing of a commercial drug product containing ethinyl estradiol and goes on to suggest improvements that could be made to the commercial manufacturing …
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Mechanistic Understanding of the NOB Suppression by Free Ammonia Inhibition in Continuous Flow Aerobic Granulation Bioreactors
A partial nitritation-anammox continuous flow reactor (CFR) was operated for eight months demonstrating that a mixture of large anammox-supported aerobic granules (ASAGs) and small conventional aerobic granules (CAGs) can be maintained stably for extended periods of time. The influent NH4+ was kept …
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Novel Carbopol-Wax Blends for Controlled Release Oral Dosage Forms
… difficulties of carbopol using hot melt granulation process and to develop sustained release oral formulations of a basic (Propranolol HCl) and an acidic drug (Glipizide).</p> <p>Hot melt granulation was used to prepare free-flowing, directly compressible carbopol-wax blends. Evaluation …
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Optimization of granule size and tablet properties in a twin screw granulator: the influence of process and formulation parameters
… and other associated processing costs in wet granulation is a benefit of melt granulation. However, twin screw hot melt granulation is rarely applied in most industries. This work details the product characteristics and optimization from melt granulation of the model materials, calcium …
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Investigation into the start-up and operation of upflow anaerobic sludge bed reactors
… of the microbial consortia involved, known as granulation, presents an obstacle to the wide-spread use of this technology. In this study, two laboratory-scale UASB reactors were commissioned for the purpose of generating datasets for model development. A sucrose-based feed was used for the …
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Novel Application of Twin Screw Extruder on Production of Diverse Formulations
… the limitation of conventional methods. Dry granulation process is necessary for some moisture sensitive APIs. However, the widely applied dry granulation technologies, slugging and roller compaction, have some limitations: single batch operation, low manufacturing throughput, high amounts of …
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