Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 188 for “"gram-positive bacteria"”.
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Biosynthetic and Functional Studies of Bacillithiol in Gram-positive Bacteria
… LMW thiol in eukaryotic cells as well as Gram-negative bacteria and mycothiol (MSH) as the dominant LMW thiol in Actinobacteria. Functional studies on those thiols have revealed their importance in cell metabolism, also their potential as target for antimicrobial development. …
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Regulation of Surface Proteins Assembly on the Wall of Gram-Positive Bacteria
… proteins are essential virulence factors in many Gram-positive bacteria. Attachment of these proteins to the peptidoglycan is achieved through a transpeptidation reaction, whereby sortase cleaves a conserved Cterminal LPXTG motif and attaches the protein to the peptidoglycan precursor lipid II. …
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Antibodies to peptidoglycan differentiate between cell wall fragments of gram-negative and gram-positive bacteria
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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An investigation into the biodegradation of peptide cyanotoxins (microcystins and nodularin) by novel gram-positive bacteria.
Cyanobacterial secondary metabolites, microcystins (MC) and nodularin (NOD) have become common contaminants in most aquatic ecosystems over recent years presenting a hazard to animal and human health. Unfortunately, these chemically diverse peptide hepatotoxins remain a challenge to most …
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Determining the mechanism of protein transit through the peptidoglycan layer in Gram-positive bacteria and identifying phage-docking sites on Clostridium perfringens
Clostridium perfringens is a Gram-positive (Gram+) anaerobic spore-forming bacterium that can act as a lethal human pathogen. Depending on the pathway of entry and strain, infection can lead to gastrointestinal disease or gas gangrene. Disease, as with nearly all bacterial pathogens, is primarily …
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On the Gram-positive bacterial cell wall.
Cell wall is the outermost part of Gram-positive bacteria. It is intricately tied to the bacteria's response to environmental stimuli and challenges, and its makeup dynamically changes as a part of bacterial adaptation. Peptidoglycan is the biopolymer that composes nearly half of the cell wall, and …
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Synthesis and Evaluation of Tetramic Acids as Antimicrobial Agents
<p>As bacterial infectious diseases are a major cause of morbity and mortality throughout the world, and many causative organisms are resistant to currently available antibiotics, the motivation for the development of new drugs is readily apparent. A number of natural products exhibiting …
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Modification of cheese flavour through the use of surface microbiota
… cheese, combined with lactic acid bacteria, contribute to lipolysis and proteolysis, degradation of free fatty acids and free amino acids, and the metabolism of lactose, citrate and lactate, with a consequent biosynthesis of volatile flavour compounds. The intense metabolic activity …
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The discovery and functional study of an antimicrobial peptide QUB-1955 from the skin secretion of the northern orange-legged leaf frog, phyllomedusa hypochondrialis
Due to the increasing resistance of bacteria to conventional antibiotics, new antimicrobial drugs need to be discovered urgently. Natural active substances extracted from skin secretions of anurans have attracted much interest in recent years. Among them, anti-bacterial peptides with broad-spectrum …
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Factors That Influence Murine Norovirus Stability and Tropism
… investigated the interactions between MNV and bacteria in vitro by determining what bacteria and bacterial components could impact viral thermostability. I found that that specific Gram-positive bacteria and conditioned medium from Gram-positive bacteria could stabilize MNV against heat …
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The Role of Base Modifications on Tyrosyl-tRNA Structure, Stability, and Function in Bacillus subtilis and Bacillus anthracis
… of this work has been carried out extensively in Gram-negative bacteria, however, the role of modified bases in tRNAs as they relate to thermostability, structure, and transcriptional regulation in Gram-positive bacteria, such as Bacillus subtilis and Bacillus anthracis, are not well …
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Blood stream infections in oncology patients at Red Cross War Memorial Children's Hospital, Cape Town
… at the haematology-oncology unit of RCWMCH. All positive blood cultures from RCWMCH oncology patients taken between 1 January 2012 and 31 December 2014 were retrieved to identify patients who had BSI. Results: Structured literature review: 508 abstracts / articles were initially retrieved and …
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Identification, characterisation and design of bioactive peptides from Chinese frogs
… it exhibited strong activity against Gram-positive bacteria but no effect on Gram-negative bacteria. A series of analogues were designed using QUB-1434 as a template, to study the structure-activity relationships of the temporins. Incorporation of Cha caused a great improvement in …
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Structural and Biochemical Studies of Nisin *Biosynthesis and Autoimmunity
… is a 34-residue bacteriocin produced by the Gram-positive bacteria Lactococcus lactis spp. It is first ribosomally synthesized as an inactive precursor which is then post-translationally modified into its mature biologically active form. Described herein is a two-part study investigating (1) …
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Glutathione utilization in lactobacillus fermentum CECT 5716
… shown to be either utilized or synthesized by gram-positive bacteria, such as Lactic Acid Bacteria. Glutathione plays an important role in countering environmental stress, such as oxidative stress. In this study, cellular activity regarding glutathione in Lactobacillus fermentum CECT 5716 is …
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Biosynthesis and Functions of tRNA 2-Thiouridine in Bacillus subtilis
… have been well characterized in eukaryotes and Gram-negative bacteria, until now, little was known about its role or formation in Gram-positive bacteria.
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Untersuchungen auf Sekundärstoffproduktion und physiologische Charakterisierung von marinen heterotrophen Bakterien aus dem deutschen Wattenmeer
… natural products from previously uncultered bacteria, over 90 isolates from the german Wadden Sea were screened for their potential for secondary metabolite production. 16 S rRNA gene analysis revealed, that 56 strains affiliated with Gram positive bacteria and 36 strains with the …
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Modification and Translocation of the Biofilm Exopolysaccharide Poly-β(1,6)-N-acetyl-D-glucosamine
Bacteria embedded within a biofilm are more resistant to antibiotics and host defenses than those in a planktonic state. Extracellular polysaccharides are a main component of biofilms and have been shown to play an important role in bacterial aggregation, surface attachment, and serve as a …
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A study of antimicrobial properties of fabric treated with silane and N-halamine complex
… for antimicrobial properties using ATCC 2695 gram positive bacteria <em>Staphylococcus aureus</em> and ATCC 8739 gram negative bacteria <em>Escherichia col</em>i. The treated samples provided very good antimicrobial properties even after three vigorous soap washings. The fabric durability …
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