Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"graft rejection"”.
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The management of corneal graft rejection
… of superficial keratectomy. The idea of corneal grafting was suggested relatively recently3,4• Guillaume Pellier de 22 Quengsy5, a Frenchman, suggested in 1789 the complete replacement of the opaque cornea using a thin glass disc the size of the cornea and set in a silver rim. He suggested that …
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THE ROLE OF DENDRITIC CELLS IN GRAFT REJECTION
… So far the acceptance of a mismatched graft is achieved through immunosuppression that requires long-term treatment and a variety of methods have been explored to prevent rejection and achieve transplant tolerance in mouse models. There are several factors that contribute to acquired …
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The percieved threat of the risk of graft rejection among organ transplant recipients
… they fear the most, the most common answer is graft rejection. Graft rejection is a real threat against an OTR since it is the body’s natural way, through its immunological defence, to protect itself against foreign bodies or unknown substances. Aim: The primary aim of this thesis was to …
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Humoral alloimmunity in cardiac allograft rejection
Although the short-term outcomes of solid allograft survival have improved substantially over the last few decades, there has been no significant improvement in long-term survival of solid allografts. This thesis presents the initial characterisation of alloantibody mediated rejection in a murine …
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Germinal centre autoantibody responses following heart transplantation
… contributes independently to chronic graft rejection. In a MHC class II-mismatched murine model, I show that antinuclear autoantibody responses were initiated upon graft-versus-host allorecognition of recipient B cells by donor CD4 T cells transferred within the heart allograft. …
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Gene therapy studies of Adenoviral IL-10 transduced Dendritic cells in allotransplantation / by Toby Coates.
… which in small animal models can modify skin graft rejection. In large animals, genetically modified dendritic cells alone were not capable of prolongation of allograft survival, suggesting that these cells may require adjuvant immunosuppressive therapy to be used in future protocols.
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Exploring Veto Activity: DNAM-1-CD155 Axis in Overcoming NK Cell-Mediated Allo-Rejection and Applications for CAR-T Cell Therapy
… anti- donor T cell clones without inducing rejection. By leveraging this unique immune property, two key research aims were proposed: “Exploration of the Impact of Veto Activity on Natural Killer (NK) Cell-Mediated Allo-rejection” and “Development of Off-the- shelf Chimeric Antigen Receptor …
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A comparison of gene expression in tolerated and rejected islet grafts by gene microarray analysis
… MHC-matched minor-antigen-mismatched islet allografts in diabetic NOD mice could be induced by simultaneous islet and bone marrow transplantation preventing both graft rejection and recurrence of autoimmunity. Despite the presence of tolerance and good graft function mononuclear cell …
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In vitro and in vivo assessments of PCL-TCP composites for bone tissue engineering
Currently, there is an unmet need for bone grafts which is the gold standard of treating patients with trauma related injuries or bone fracture. Autologous bone graft poses no issues of rejection but will result in donor site morbidity and is limited by defect size. Allografts and xenografts are …
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ΣΥΜΒΟΛΗ ΣΤΗΝ ΜΕΛΕΤΗ ΤΩΝ ΛΟΙΜΩΞΕΩΝ ΑΠΟ ΜΕΓΑΛΟΚΥΤΤΑΡΟΙΟ (CMV) ΣΤΟΥΣ ΛΗΠΤΕΣ ΝΕΦΡΙΚΩΝ ΜΟΣΧΕΥΜΑΤΩΝ. ΣΥΣΧΕΤΙΣΗ ΜΕ HLA ΑΝΤΙΓΟΝΑ
… FEATURES OF THE DISEASE, ITS INTERFERENCE WITH GRAFT REJECTION AS WELL AS ITS CORRELATION TO HLA, WERE STUDIED IN 47 KIDNEY GRAFT RECIPIENTS. RESULTS CAN BE SUMMARISED AS FOLLOWS: A) ANTIBODIES TO CMV VIRUS WERE FOUND IN 58.9% OF THE RECIPIENTS. IN A CONTROL POPULATION STUDY ANTIBODIES TO CMV …
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Destruction of Corneal Nerves Promotes Corneal Allograft Rejection
… to the 90% success rate of corneal allografts without the need for histocompatibility matching and use of systemic immunosuppressive therapy. However, when one or more parameters that contribute to immune privilege are broken, the cornel allograft becomes vulnerable to the immune system, …
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A comparative study of common crosslinking agents for electrospun collagen scaffolds
… to maintain an active life style. Synthetic grafts are used extensively to restore tissue functions. The major drawback limiting successful incorporation of synthetic grafts in body is their lower ability to integrate to natural tissue, poor biocompatibility which often results in triggering …
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Design, synthesis, and evaluation of release kinetics of novel LFA-1 and TLR-4 inhibitor prodrugs for localized immunomodulation.
… of organ transplant recipients experience graft rejection due to acute immune responses of the innate and adaptive immune systems. Traditionally, systemic immunosuppression has been used to mitigate these immune responses against the graft, however this can lead to systemic toxicity and …
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Review of liver biopsies at Red Cross War Memorial Children's Hospital over a six-year period
… biopsy were hyperbilirubinemia and suspected graft rejection. Conclusion: Although liver biopsy is an invasive procedure, if guidelines are adhered to and performed by experienced staff it can be justified when using standard indications as it has a low complication rate in our setting and …
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FROG DECLINES: EXPLORING CONNECTIONS AMONG CLIMATE CHANGE, IMMUNITY AND DISEASE
… (thymus growth, antibody production and skin graft rejection) in Meadow treefrogs (Hyla pseudopuma), a declining species in the MCFP, when tadpoles developed under various water regimes. During the wet seasons of 2001-2004, laboratory experiments were conducted in the MCFP by subjecting …
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Xanthene/Benzoxanthene Dyes: Novel Synthetic Metholologies, Applications in Molecular Recognition, Cellular Imaging and the Design of a Tunable White (RGB) Light Emitter
… cell surface residue involved in cancer, graft rejection and virulence in certain bacteria. There is no interference from commonly occurring oligosaccharides, aminosugars and most carboxylic acid-containing compounds. Improved synthetic methodology and studies of novel molecular probe …
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Das Krankheitsbild und die Behandlungsalternativen der Unterlidretraktion bei Patienten mit Morbus Basedow nach transpalpebraler Orbitadekompression : Gegenüberstellung der Ergebnisse nach Konchaknorpel- und PDS-Folienimplantation in Hinsicht auf Funktionalität und Ästhetik
… developed specifically for this study. After graft implantation a statistically significant improvement of Margin-Reflex-Distance-2 (MRD-2) as well as of scleral-show values was evident with both materials. However, the assessment of mean difference in MRD-2 and scleral-show values in this …
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Overcoming skin rejection in composite tissue allotransplantation
… is constrained by the susceptibility of skin to rejection. The aim of this thesis is to improve our understanding of skin rejection and find ways to avoid it, in order to enable expansion of the application of composite tissue transplantation techniques. The first part of the thesis explores the …
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Immunomodulatory biomaterials to promote early transplant integration and wound healing
… reduced the rate of postoperative morbidity and graft loss. Despite these advances, wound complications due to systemic immunosuppression are a common post-transplant surgical complication. Therefore, there is a need for therapies that have the ability to allow for wound healing while also …
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Molecular Characterization of the Human Alloimmune Response
… in vitro proliferations translate in vivo into graft rejection of stem cell and solid organ transplants and to graft versus host disease (GvHD) in recipients of allogeneic stem cell transplants. Defining the clonal T cell responses elicited in an MLR between two individuals is complicated by the …
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