Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"gp120"”.
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Glia-mediated mechanisms of HIV-1-gp120-induced Synaptic Degeneration
… we tested the role of HIV- envelope protein gp120 in pathogenesis of degeneration both in the spinal cord and the cortex. In the spinal cord, gp120 exposure caused synaptic degeneration. Because gp120 induced microglial activation, we further tested the hypothesis that microglia contribute to …
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The Effect of Drugs of Abuse and HIV-1 GP120 on Autophagy in Astrocytes
… mediated by cocaine, methamphetamine, and HIV-1 gp120 is determined. Furthermore, we examined the cellular mechanisms responsible for cocaine and methamphetamine-mediated autophagy pathway, and the role of autophagy in drug-induced cytotoxicity. In the first chapter, we investigate the effect of …
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Engineering of HIV gp120 by yeast surface display for neutralizing antibody characterization and immunogen design
The sequence diversity of glycoprotein gp120 of the envelope spike of Human Immunodeficiency Virus (HIV) allows the virus to escape from antibody selection pressure. Certain conserved epitopes, like the CD4 binding site, are required for viral fitness and antibodies against these epitopes are able …
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Development and Evaluation Of HIV gp120 Responsive Microbicide Formulation for the Prevention of HIV Sexual Transmission
… microbicide formulation capable of targeting HIV gp120 for the prevention of HIV sexual transmission. In Chapters 1 and 2, the general hypothesis, aims and scope of this work are introduced. Chapter 3 covers the literature review of anti-HIV lectins and current delivery approaches. In Chapter 4, …
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HIV-1 gp120 and Methamphetamine-mediated Induction of Proinflammatory Cytokines/chemokines and Oxidative Stress in Astrocytes: Implications in Neuroinflammation
… infected with HIV. The viral envelope protein, gp120 has been extensively studied and some of its neurotoxic effects are due to the increased expression of various proinflammatory cytokines. Additionally, it has been well documented that various drugs of abuse can exacerbate HAND, but the …
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Structure-based Design of Small Molecule Inhibitors of HIV-1 Entry
HIV infection begins when gp120 envelope protein on the viral surface binds to the CD4 receptor on the host cell. This initial protein-protein interaction starts the rest of the HIV lifecycle of coreceptor binding, fusion and replication. One of the targets of HIV entry inhibitors is the …
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HIV-1 Envelope-Induced Signaling Mediates Actin Cytoskeleton Rearrangements Necessary for Fusion and Entry
… mediated by the envelope: Env) surface subunit gp120 and the transmembrane subunit gp41 which anchors gp120 into the viral membrane. First the surface subunit gp120 binds to the primary receptor CD4. This interaction promotes actin cytoskeletal rearrangements in the target membrane that bring …
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Herstellung und Charakterisierung eines anti-HIV-Inhibitors basierend auf modifiziertem Serum Albumin
… Verhältnis HSA zu HOCl 1:1000) an das HIV-1 gp120 bindet, wurde es VEBP (Virus Envelope Bindendes Protein) genannt. In einem Synzytien-Test wurde die Wirksamkeit des VEBP gegen HIV-1 überprüft. Zellen, die CD4, CXCR4 und CCR5 exprimieren, wurden mit einem gp160-Expressionsvektor transfiziert …
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HIV Tat Protein Activates Endothelial Cells through NFκB and MAP Kinase Pathways.
… by HIV itself or by its secreted proteins, gp120 (a viral envelope protein) and tat (a protein that upregulates transcription of viral genes). We have studied the effects of gp120 and tat on signaling and production of inflammatory cytokines by Human Pulmonary Artery Endothelial Cells …
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HIV-1 Immune Escape and Neutralizing Antibodies : Solid Phase Proteoliposomes Containing HIV-1 Envelope Glycoproteins as Antigens and Immunogens and HIV-1 Core Envelope Glycoproteins Deficient in T-Helper Epitopes
The HIV-1 envelope glycoproteins gp120 and gp41 mediate binding and fusion of the virus to target cells. The envelope glycoproteins are exposed on the surface of the virus as trimeric spikes and are the major targets for neutralizing antibodies. The design of envelope glycoprotein-based subunit …
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Structure and function of glutamate transporters
… modeling of two other proteins: the HIV gp120 envelope protein (gp120) and NAD(P)H:Quinone Oxidoreductase 1 (NQO1). The study of gp120 involved a statistical analysis of substitutions that occur during early infection of clade A HIV, showing that during early infection substitutions are …
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Structure and function of glutamate transporters
… modeling of two other proteins: the HIV gp120 envelope protein (gp120) and NAD(P)H:Quinone Oxidoreductase 1 (NQO1). The study of gp120 involved a statistical analysis of substitutions that occur during early infection of clade A HIV, showing that during early infection substitutions are …
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Monosacchacharid-Konjugate von Inhibitoren der O6-Methylguanin-DNA Methyltransferase, der Poly-(ADP-ribose) Polymerase und des SWITCH Phänomens des HIV Hüllproteins gp120 : Synthese, biologische Aktivität und Struktur-Wirkungsbeziehungen
… wiesen im modifizierten gp120-CD4-Bindungsversuch eine 400 bis 2500 mal höhere Wirksamkeit au
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Characterisation of llama antibody fragments able to act as HIV-1 entry inhibitors
… envelope spike, which consists of trimers of gp120 bound to gp41. Most variants of HIV-1 enter cells through attachment of the envelope spike to the main cellular receptor CD4, allowing interaction with a co-receptor and eventually fusion of viral and cellular membranes. Neutralising …
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The Rational Design, Synthesis, And Biological Evaluation Of Small Molecule Cd4 Mimetic Families For Hiv-1 Viral Entry Inhibition
… CD4, which binds within the viral envelope’s gp120 glycoprotein subunit. Binding of CD4 and gp120 elicits a cascade of events that ultimately results in viral entry into host cells. The small molecule CD4 mimetics developed by the Smith laboratory are able to bind within the gp120-CD4 binding …
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Modulating the Antigenicity and Immunogenicity of HIV-1 Envelope by a Conserved N-Linked Glycan
… acid residue 197 (N7) on the surface antigen gp120 of HIV-1 envelope glycoprotein (Env) increases neutralization sensitivity of the mutant virus to CD4 binding site (CD4bs)-directed antibodies and enhanced the ability of Env to generate cross-reactive neutralizing responses as compared to its …
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HIV Specific B Cell Response in Patients With Broadly Neutralizing Serum Activity
… expressing high affinity antibodies to the gp120 variable loops, the CD4 binding site, the co-receptor binding site, to a new neutralizing epitope that is in the same region of gp120 as the CD4 binding site and to gp41. In four patients highly potent broadly neutralizing antibody clones …
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Signal processing-based bioinfomatics methods for characterisation and identification of bio-functionalities of proteins
… reported fairly unstable Surface Protein (HIV gp120) so as to deactivate HIV and possibly cure AIDS, it was later found that mutations in the HIV gp120 are linked to its numerous physiological characteristics. Further study on the effects of mutations on HIV gp120 helped demonstrate the …
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Effects of galectins and antibodies in HIV infection; Novel Assays
… To explore this, we examined the interaction of gp120 (the surface Env protein) with a panel of galectins, by adapting the fluorescent anisotropy (FA) assay to microscale. Galectin-8, a galectin with two carbohydrate recognition domains (CRDs), had high affinity for gp120 as well as the HIV …
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