Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"gonadotropes"”.
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New stimulators and a new mechanism of regulated secretion in pituitary gonadotropes
… i}$). I used cultured pituitary gonadotropes of male rats to seek other possible agents and mechanisms that might regulate gonadotropin secretion. The GnRH-evoked (Ca$\sp{2+}\rbrack\sb{\rm i}$ rise is oscillatory and accompanied by oscillations of outward K$\sp{+}$ current that is …
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The glucocorticoid receptor plays a central role in mammalian reproduction and signal integration in pituitary gonadotropes
Reciprocal modulation between the glucocorticoid receptor (GR) and gonadotropin-releasing hormone (GnRH) signalling pathways is a potential mechanism for integrating cellular responses to stress with reproductive function. This study investigated if membrane rafts play a role in GR and GnRH …
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IQGAP1 is a novel effector of gonadotropin-releasing hormone receptor signaling
… these domains in response to GnRH. Using αT3-1 gonadotropes, we identified 537 proteins in detergent-free subcellular fractions containing low-density plasma membranes. SILAC (stable isotope labeling by amino acids in cell culture) in combination with mass spectrometry demonstrated that GnRH, …
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The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation
… lines. The GnRHR couples to Gαq in pituitary gonadotropes. However, the GnRHR expressed in reproductive cancer cell lines is thought to couple to Gαi. Recent evidence also suggests that the antiproliferative effects may be mediated via Gαq in these cells. Therefore our study involved …
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The role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivity
… inteacts with GnRH type I receptors on the gonadotropes in the anterior pituitary. Activation of the GnRH receptor is required for the biosynthesis and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH), which regulate reproductive function. Multiple forms of GnRH are …
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The regulation of the luteinizing hormone (LH) and the follicle stimulating hormone (FSH) by glucocorticoids and progestins
… progestins exert direct actions on pituitary gonadotropes. It was further hypothesized that while both progestins are progestogenic and could act via the progesterone receptor (PR), MPA would most likely also exert glucocorticoid like actions via the glucocorticoid receptor (GR), unlike NET. …
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The role of steroidogenic factor-1 (SF-1) in gonadotropin-releasing hormone (GnRH) receptor gene regulation
… high levels of GnRHR expression in the pituitary gonadotropes.
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Dissection of GnRH receptor-G protein coupling
… G proteincoupled receptor (GPCR) on pituitary gonadotropes and activates Gq/11-mediated signalling pathways to stimulate the biosynthesis and the release of luteinising hormone (LH) and follicle-stimulating hormone (FSH). Both GnRHs have also been suggested to inhibit cellular proliferation, an …
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Uncovering novel actions of numb and aryl hydrocarbon receptor in the pituitary
… intermediate lobe cells, as well as the gonadotropes in the anterior lobe. Full Numb knockout mice (Numb-/-) are embryonic lethal before development of the pituitary, so the work described here utilized a Cre-loxP conditional knockout system driven off the Pomc promoter to delete Numb and …
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The Role of Neurokinin B in the Regulation of the Preovulatory LH Surge in Ewes
… reaches the anterior pituitary, it stimulates gonadotropes to secrete luteinizing hormone (LH) into the systemic circulation, ultimately leading to ovulation. GnRH/LH secretion occurs in two different patterns: pulsatile or surge. Pulsatile GnRH release is governed by estradiol (E2) negative …