Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 361 for “"golgi"”.
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LDLC encodes a peripheral golgi protein required for normal Golgi function
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1995.
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Golgi phospholipid composition is a critical determinant of Golgi secretory competence in yeast
Golgi secretory function in Saccharomyces cerevisiae is strictly dependent upon the activity of the SEC14 gene product, the Sec14p. Yeast strains bearing temperature-sensitive mutations in the SEC14 gene exhibit defects in protein trafficking from the Golgi and otherwise wild type cells which lack …
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THE TRANSCRIPTIONAL PROGRAM OF GOLGI BIOGENESIS
The Golgi apparatus is considered a fundamental organelle that regulates various physiological processes. Due to its plasticity, it can expand during differentiation and in response to high secretory demand. However, transcriptional contribution to Golgi biogenesis remains poorly understood because …
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ER to Golgi transport during apoptosis
The Golgi complex, a single -copy organelle, is composed of a ribbon of flattened stacks of cisternae during interphase. However, during apoptosis the Golgi is shown to fragment and disperse throughout the cytoplasm. Immunoelectron microscopy identified these fragments as vesicular-tubular …
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The Role of ER-Golgi Membrane Contact Sites and of FAPP1 in Phosphoinositide Homeostasis at the Golgi Complex
… and cell migration. PI4P levels at the Golgi in control conditions are the result of the balanced activity of Golgi-localized PI4-kinases (PI4KIIIβ and to a lesser extent PI4KIIα) and a single, highly conserved 4-phosphatase known as SAC1, localized in the ER. To coordinate such a …
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Golgi Specificity and Development of Autoreactive B Cells
… the Vk38c light chain may have specificity to a Golgi antigen in addition to DNA. This suggested that such anti-DNA receptors may bind to an intracellular Golgi antigen and remain hidden inside the cell. Thus B cell receptor-cloistering in immature B cells, during development in the bone marrow, …
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Yeast Dynamin Functions with Clathrin at the Golgi
… endocytosis, but also traffic from the Golgi to endosomes. In this study, the interdependency between Vps1 and clathrin was investigated. Subcellular localization of clathrin was at the Golgi, early and late endosomes, implicating clathrin in multiple trafficking pathways within the …
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Investigating the trafficking of Golgi-resident glycosylation enzymes
The Golgi is a major site of glycan processing mediated by a large number of Golgi-resident glycosylation enzymes. These enzymes are largely type II transmembrane domain (TMD) proteins consisting of a short N-terminal cytosolic tail, a short TMD and a lumenal ‘stem’ region which separates the …
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Protein quality control processes in the yeast golgi
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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Studies on the structural organization of Golgi complex
Golgi complex is a multi-compartmental organelle involved in posttranslational modification and sorting of secretory proteins. We have characterized the distribution in Vero cells of three Golgi cisternal membrane proteins, Sialyltransferase (SialylT, tans- Golgi/TGN), galactosyltransferase(GalT, …
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Interactions between the plant Golgi apparatus and the cytoskeleton
In animal cells, the relationship between the Golgi apparatus and cytoskeleton has been well characterised but not much is known in plants. The functions of the Golgi apparatus are conserved amongst eukaryotes. It is one of the main stations in the secretory pathway and is involved in protein …
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Role of trans-Golgi network vesicles in mitochondrial fusion
… The results presented here indicate that trans-Golgi network vesicles (TGNv) are recruited to mitochondrial fusion sites and accelerate the speed of fusion. Super resolution live cell imaging revealed that TGNv are recruited downstream of the endoplasmic reticulum (ER), suggesting that the ER …
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The Mitotic Spindle Mediates Inheritance of the Golgi Ribbon Structures
The mammalian Golgi ribbon disassembles during mitosis and reforms in both daughter cells after division. Mitotic Golgi membranes concentrate around the spindle poles, suggesting that the spindle may control Golgi partitioning. To test this, cells were induced to divide asymmetrically with the …
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Novel regulators of trafficking in the yeast Golgi-endosomal system
… into the molecular mechanisms that direct post-Golgi trafficking events in the budding yeast Saccharomyces cerevisae. However, a key event in this process, the formation of secretory vesicles at the Golgi and sorting of cargo into these transport carriers, remains poorly understood. It has been …
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Vps1's Role From the Early Endosome to the Golgi
… including protein trafficking from the late Golgi-to-endosome, peroxisome fission, vacuole fission and fusion, and retention of Golgi proteins. We recently observed in FM4-64 pulse-chase experiment with vps1 null cells that the levels of accumulated FM4-64-carrying transport vesicles …
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Strukturelle Untersuchungen zur Inhibierung und Biogenese des pflanzlichen Golgi-Apparates
… (NDGA) auf Sekretion und Struktur pflanzlicher Golgi-Apparate zu unterschiedlichen Zeitpunkten des Zellzykluses untersucht. Im zweiten Teil wurde die de novo Entstehung pflanzlicher Golgi-Apparate beschrieben. Im Rahmen dieser Untersuchungen sollte in erster Linie der zeitliche Verlauf der …
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Untersuchung von Proteinkomponenten der ER-Golgi Recycling-Maschinerie von Hefe
… alle bisher untersuchten ER-Proteine, die zum Golgi gelangen, mit Hilfe von COPI-Vesikeln zum ER zurücktransportiert. Bisher ist aber noch ungeklärt, wie die unterschiedlichen Proteine in die Vesikel dirigiert werden.Durch Verwendung eines Sec22-a-Hybridproteins konnte in unserer Arbeitsgruppe …
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Characterising the factors involved in ER-to-Golgi anterograde trafficking
The Golgi apparatus is a major hub of protein transport, modification and sorting. Secreted and membrane proteins are synthesised in the Endoplasmic Reticulum (ER) and are packaged into carrier vesicles at ER exit sites. The carriers are transported to the cis-Golgi apparatus, where they fuse with …
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The Golgi Complex of the Hepatocyte: Isolation and Partial Enzomological Characterization
<p>The elements of the Golgi complex of the hepatocyte are characterized by their content of 30-80m osmiophilic particles, which have been identified by others as very low density lipoprotein. The vast majority of such particles in the cell are in the elements of the Golgi complex. Moreover, the …
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The role of Atgolgin-84A at the plant ER-Golgi interface
… namely endoplasmic reticulum (ER) and Golgi bodies, are part of a so-called secretory pathway where vital cell components travel to reach the correct final destination or are recycled for further processing. In the plant cell cytoplasm there are numerous stacks of membrane bounded …
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