Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"goblet cell"”.
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Clinical and Molecular Analyses of Intestinal Goblet Cell Acidomucins and Cysteine Metabolism
Goblet cells are key contributors to intestinal mucosal barrier function through their role in production of mucins and other important secretory products, which include trefoil factor 3 (TFF3) and resistin like molecule β (RETNLB). Goblet cell mucins show great structural heterogeneity but can be …
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Dietary protein ameliorates goblet cell loss and modifies inflammatory responses in the colon of hnRNPI knockout mouse
… specifically knockout in intestinal epithelial cells (IECs) develop spontaneous colitis at an early age. Moderate dietary protein has been demonstrated to exert beneficial effects for individuals with colitis, however, mechanisms of how dietary protein impacts inflammation development and immune …
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The effect of butyrate-supplemented total parenteral nutrition on muc2 mRNA and goblet cell chemotypes in a short bowel syndrome neonatal piglet model
… with 9 mM butyrate will enhance protective goblet cell chemotypes in the small intestine, specifically sulfomucins, that enhancement of protective goblet cell chemotypes in the SCFA-supplemented group will be observed, since this group also contains 9 mM butyrate, that butyrate-supplemented …
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Effects of high incubation temperature on the developing small intestine and yolk sac of broiler chicks with insight into goblet cell development in the small intestine early posthatch
… depth of the crypt, which is the site for stem cells. Chicks from eggs incubated at a higher temperature had a lower crypt depth in the duodenum and jejunum. There was no difference in the expression of the intestinal stem cell marker olfactomedin 4 (Olfm4) and mucin 2, which is secreted by …
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A Novel Mouse Model of Asthma Induced by Cockroach
… inflammation, IL-13 in BAL fluid, and goblet cell hyperplasia of respiratory epithelium, however, did not affect AHR. Endotoxin-depleted CR also attenuated eosinophilic inflammation and lymphocytosis in BAL fluid, but did not affect AHR and IL-13 levels in BAL fluid compared to CR …
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The intrinsic role of SOCS1 in intestinal epithelial cells
… To define its role in intestinal epithelial cells (IEC), our laboratory created a mouse model of Socs1 gene deletion in IEC lineages of the small and large intestines. Analysis of this Socs1ΔIEC mouse model suggests that lethal ulcerative colitis might be driven by Paneth and goblet cell …
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The role of mucus in the cross talk between gut bacteria and the host
… the impact of IELs on mucus properties, a γδ T cell-deficient (TCRδ-/-) mouse model was used. TCRδ-/- mice showed increased susceptibility to dextran sodium sulphate (DSS)-induced colitis, alterations in mucin expression, glycosylation and goblet cell numbers, but maintained an intact mucus …
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Effects of Host-derived Probiotics on the Growth Performance and Health of Tilapia and Carp
… were assessed for haemolytic activity and extracellular enzyme production <i>in vitro</i>. Isolates C61 and T70, demonstrated superior probiotic traits and were identified as strains of <i>Bacillus subtilis</i>. Both retained over 85% of their pathogen antagonism against <i>A. hydrophila</i> …
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A mouse model of childhood asthma: mechanisms of development and progression following an early-life respiratory viral infection
… to the development of allergic inflammation, goblet cell change and AHR, because these were absent in receptor-deficient mice. Administration of anti-IL-4 during chronic challenge inhibited allergic airway inflammation and goblet cell hyperplasia/metaplasia, but not other changes of …
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Effects of dietary enzyme supplementation on performance, bone ash, small intestinal morphology, and apparent ileal amino acid digestibility of broilers exposed to a live coccidia oocyst vaccine
… IAAD in EXP 3. Small intestinal morphology and goblet cell numbers were affected by enzyme supplementation and vaccination, which resulted in significant (P ≤ 0.05) interactions. In general, vaccination increased (P ≤ 0.05) small intestinal crypt depth and reduced (P ≤ 0.05) goblet cell numbers …
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MEDIATORS OF ACUTE INFLAMMATION AND THEIR ROLES IN MODULATING IN VI3^ LEUKOCYTE INFILTRATION AND PATHOBIOLOGIC ACTIVITY IN THE CONJUNCTIVA
… to the conjunctival epithelium and depletion of goblet cell numbers was correlated with the presence of degranulated and fragmenting eosinophils. In animals presensitized to ovalbumin, antigen challenge evoked extensive accumulations of degranulated and fragmenting eosinophils concurrent with …
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Investigating the Spatiotemporal Variation in Functional Markers, Gut Metabolites and Ethanol Toxicity in In Vitro Cultures of the Rat Jejunum and Hepatocytes
… models that investigate the use of primary cells/tissues from the liver and the intestine to study their interaction and importance in manifestation of drug toxicity. The studies described in this dissertation were conducted using inverted rat intestinal explants obtained from three regions …
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The role of IL-4Rá in Nippostrongylus brasiliensis-induced chronic lung pathology
… the induction of pulmonary pathology, including goblet cell hyperplasia and acute airway inflammation, depend on IL-4Rá signalling. A key feature of IL-4Rá signalling is the induction of a strong TH2 response which induces the development of alternatively activated macrophages (AAMs). AAMs are …
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The role of Dietary Interventions in Broiler Intestinal Health and Immunity
… enzyme capacity, apoptotic and necroptotic cell death levels and the expression of inflammatory cytokines. Supplementation of diet with each mannan-rich fraction (MRF) increased villus height and villus surface area. In addition, crypt depth was increased upon dietary inclusion of …
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Krupple-Like Factor 4 Regulation in Intestinal Epithelial Differentiation, Proliferation and Polarity
… is predominantly expressed in the epithelial cells that are fully differentiated in normal intestine. In colorectal cancer, KLF4 was identified as a tumor suppressor; it is also a stem cell factor that along with other factors can induce pluripotent stem cells. KLF4 knockout mice demonstrate …
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The role of pulmonary innate and adaptive immune responses to helminth infection
… T helper 2 (Th2) response promoted by epithelial cell driven IL-33 induction of cytokine secretion of Interleukin (IL)-4, 5 and 13 by a range of immune cells including innate lymphoid cells type 2 (ILC2s) and CD4+ T cells. This induces effector responses such as goblet cell mucus secretion and …
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The role of pulmonary innate and adaptive immune responses to helminth infection
… T helper 2 (Th2) response promoted by epithelial cell driven IL-33 induction of cytokine secretion of Interleukin (IL)-4, 5 and 13 by a range of immune cells including innate lymphoid cells type 2 (ILC2s) and CD4+ T cells. This induces effector responses such as goblet cell mucus secretion and …
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Investigating the potential utilisation of black soldier fly (Hermetia illucens) as an alternative protein source in tilapia and carp feed
… fold length, muscularis thickness, and goblet cell density, while intraepithelial lymphocytes abundance and enterocyte microvilli length were elevated only at 40% BSF meal. Posterior intestinal endochitinase A, slc6a18, and cytokines (il1β, tnfα, il10) in either the intestine or head …
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Follow your gut: Does AKR1D1 impact gastrointestinal health?
… junction mRNA and protein levels were altered, goblet cell number and mRNA levels of key antimicrobial peptides were reduced. To examine the mechanisms that underpin these changes, caecal bile acid levels were examined. AKR1D1 KO mice had reduced total bile acid levels and altered bile acid …
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Characterising dysbiosis in Alzheimer’s disease utilising the APP/PS1 mouse model
… of tissue architecture in addition to goblet cell and enteroendocrine cell (EEC) counts were performed. Mucosal and luminal bacterial community profiling was assessed through quantitative real-time PCR (qRT-PCR) and denaturing gel gradient electrophoresis (DGGE). There was a significant …
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