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Showing 1 to 12 of 12 for “"gnotobiotic pigs"”.
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Pathogenesis, immunity, and prevention of human norovirus infection in gnotobiotic pigs
… system and a suitable small animal model, while gnotobiotic (Gn) pigs have been a unique animal model for understanding HuNoV pathogenesis and immunity, as well as evaluating vaccine and therapeutics. Recent reports of HuNoVs infection and replication in B cells supplemented with commensal …
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Studies of pathogenesis, innate immunity and therapeutics of human enteric viruses in gnotobiotic pigs
… effective prevention and treatment strategies. Gnotobiotic (Gn) pigs are an attractive animal model for studying enteric viruses due to their similarities to humans, particularly in regards to the immune system and gastrointestinal anatomy and physiology. Here, to establish a reliable Gn pig …
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Influence of Enteric Microbiota on Human Rotavirus and Human Norovirus Infection, and Rotavirus Immunity in Gnotobiotic Pigs
… response to these pathogens and vaccines. Using gnotobiotic (Gn) pigs transplanted with human gut microbiota (HGM), we studied the effects of HGM on the immune response to oral rotavirus vaccination and rotaviral disease. We also used HGM transplanted Gn pigs to determine the effects of HGM on …
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Effect of cereal type and commensal bacteria on availability of methionine sources and intestinal physiology in pigs
… a series of experiments using conventional and gnotobiotic pigs. At 14 d of age, sow - reared conventional (CON) pigs and isolator - reared monoassociated gnotobiotic pigs (EF) were weaned to corn or wheat/barley based diets supplemented with MET or MHA-FA. At 24 d of age, after an overnight …
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A cultivable primate calicivirus causes enteric infections in gnotobiotic piglets
… the pathogenesis of TV can be recapitulated in gnotobiotic piglets, (ii)Whether TV can be adapted to pig macrophage cell line, (iii)Whether macrophage-adapted TV has altered virulence in piglets, and (iv)Whether TV can be passed repeatedly in piglets. To determine the pathogenesis of TV in …
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Pathogenesis and Cross-species Infection of Hepatitis E Virus
… and several other animal species including pigs and rabbits. An ever-expanding host range of genetically-diversified strains of HEV now include bat, fish, rat, ferret, moose, wild boar, mongoose, deer, and camel. Additionally, the ruminant species goats, sheep, and cattle have been …
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Vesicular Stomatitis Virus as a Vector to Deliver Virus-Like Particles of Human Norovirus: A New Live Vectored Vaccine for Human Norovirus
… confers protection from human NoV challenge, a gnotobiotic pig model was developed. Newborn gnotobiotic piglets vaccinated intranasally with rVSV-based vaccine (rVSV-VP1) produced high levels of specific serum IgG and fecal and vaginal IgA antibody. Three weeks after vaccination, piglets were …
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Gnotobiotic Pig Models for the Study of Enteric Pathogen Replication and Pathogenesis
… each infection are imperative. We have developed gnotobiotic (Gn) pig models for each pathogen. Gn pigs infected with spores of the hypervirulent UK1 strain of C. difficile develop classical signs of infection, including watery diarrhea and weight loss. Gross necropsy reveals colonic distention …
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Evaluation of the novel P particle vaccine candidate against human norovirus using the gnotobiotic pig challenge model
… of the full-length VP1. My studies utilize a gnotobiotic (Gn) pig model of human NoV infection and diarrhea to evaluate the protective efficacy and T cell responses induced by P particles and to compare them with prior NoV infection (NoVPO) and VLPs. Gn pigs received 100 µg of P particles …
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Investigation of Novel Prophylactics Against Human Rotavirus Using Gnotobiotic Pig Models
… and more efficacious vaccines are needed. The gnotobiotic (Gn) pig model of HRV infection and diarrhea has long been used in the evaluation of novel HRV vaccines due to Gn pigs' susceptibility to HRV infection, development of clinical signs, histopathological changes in the intestine, and the …
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Mechanisms of Immunomodulation By Probiotics: Influence of Lactobacilli On Innate and T Cell Immune Responses Induced By Rotavirus Infection and Vaccines
… induced by rotavirus infection and vaccines in a gnotobiotic pig model of human rotavirus (HRV) infection and vaccination. We first studied the effects of probiotics on antigen-presenting cells (APCs) through TLR activation. We found that a mixture of Lactobacilli acidophilus strain NCFM (LA) and …
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Study of enteric virus infection and parenteral vaccines in the gnotobiotic pig model
… morbidity and mortality around the world. Gnotobiotic (Gn) pigs are the ideal large-animal model that allows for accurate, and precise, preclinical evaluation of vaccine efficacy. Similarities in gastrointestinal anatomy, physiology, and immune system allows for direct translation of …