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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"gnotobiotic"”.
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The Pathogenesis of Aujeszky's Disease in Gnotobiotic Piglets
Made available in DSpace on 2014-12-11T21:33:44Z (GMT). No. of bitstreams: 1 7212253.pdf: 5558761 bytes, checksum: afb7aff7e22622e8b87a35dd79d3d1bb (MD5) Previous issue date: 1971
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A cultivable primate calicivirus causes enteric infections in gnotobiotic piglets
… the pathogenesis of TV can be recapitulated in gnotobiotic piglets, (ii)Whether TV can be adapted to pig macrophage cell line, (iii)Whether macrophage-adapted TV has altered virulence in piglets, and (iv)Whether TV can be passed repeatedly in piglets. To determine the pathogenesis of TV in …
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Experimental enteric colibacillosis in gnotobiotic swine utilizing the ligated loop technique
Thesis (M.S.)--Michigan State University. Dept. of Pathology, 1974
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Investigation of Novel Prophylactics Against Human Rotavirus Using Gnotobiotic Pig Models
… and more efficacious vaccines are needed. The gnotobiotic (Gn) pig model of HRV infection and diarrhea has long been used in the evaluation of novel HRV vaccines due to Gn pigs' susceptibility to HRV infection, development of clinical signs, histopathological changes in the intestine, and the …
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Pathogenesis, immunity, and prevention of human norovirus infection in gnotobiotic pigs
… system and a suitable small animal model, while gnotobiotic (Gn) pigs have been a unique animal model for understanding HuNoV pathogenesis and immunity, as well as evaluating vaccine and therapeutics. Recent reports of HuNoVs infection and replication in B cells supplemented with commensal …
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Characterization of Human Gut Microbiota Dynamics Using Model Communities in Gnotobiotic Mice
… characterized in a highly controlled manner in gnotobiotic mice, plus a suite of scalable molecular tools for assaying community properties. These tools were first used to evaluate how the microbiota is impacted by probiotic bacterial strains found in fermented milk products: FMP). Introduction …
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Gnotobiotic Pig Models for the Study of Enteric Pathogen Replication and Pathogenesis
… each infection are imperative. We have developed gnotobiotic (Gn) pig models for each pathogen. Gn pigs infected with spores of the hypervirulent UK1 strain of C. difficile develop classical signs of infection, including watery diarrhea and weight loss. Gross necropsy reveals colonic distention …
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The Life Cycle and Pathogenicity of Isospora Suis in Gnotobiotic and Conventionalized Piglets
… stages of the life cycle were studied in four gnotobiotic piglets infected with dosages of up to 5 x 10('7) oocysts and sacrificed and 24 and 48 hours p.i. To study the possible presence of extra-intestinal stages, liver/spleen, and intestinal lymph node homogenates from two infected piglets, …
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Study of enteric virus infection and parenteral vaccines in the gnotobiotic pig model
… morbidity and mortality around the world. Gnotobiotic (Gn) pigs are the ideal large-animal model that allows for accurate, and precise, preclinical evaluation of vaccine efficacy. Similarities in gastrointestinal anatomy, physiology, and immune system allows for direct translation of …
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Protective role of lignan-converting bacteria on chemically-induced breast cancer in gnotobiotic rats
… (DMBA)-induced breast cancer in gnotobiotic rats was investigated. Germ-free rats were associated with a defined lignan-converting consortium (Clostridium saccharogumia, Blautia producta, Eggerthella lenta, and Lactonifactor longoviformis). The rats colonized with …
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Studies of pathogenesis, innate immunity and therapeutics of human enteric viruses in gnotobiotic pigs
… effective prevention and treatment strategies. Gnotobiotic (Gn) pigs are an attractive animal model for studying enteric viruses due to their similarities to humans, particularly in regards to the immune system and gastrointestinal anatomy and physiology. Here, to establish a reliable Gn pig …
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Study of Infection, Immunity, Vaccine and Therapeutics Using Gnotobiotic Pig Models of Human Enteric Viruses
With the absence of gut microbiota, gnotobiotic (Gn) pigs are a unique animal model for studying infection and immunity, and evaluating vaccine and therapeutics for human enteric pathogens. Here, we demonstrate Gn pigs as effective large animal models for human enteric viruses, through evaluating …
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Evaluation of the novel P particle vaccine candidate against human norovirus using the gnotobiotic pig challenge model
… of the full-length VP1. My studies utilize a gnotobiotic (Gn) pig model of human NoV infection and diarrhea to evaluate the protective efficacy and T cell responses induced by P particles and to compare them with prior NoV infection (NoVPO) and VLPs. Gn pigs received 100 µg of P particles …
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Influence of Enteric Microbiota on Human Rotavirus and Human Norovirus Infection, and Rotavirus Immunity in Gnotobiotic Pigs
… response to these pathogens and vaccines. Using gnotobiotic (Gn) pigs transplanted with human gut microbiota (HGM), we studied the effects of HGM on the immune response to oral rotavirus vaccination and rotaviral disease. We also used HGM transplanted Gn pigs to determine the effects of HGM on …
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Effect of oxygen and carbon dioxide tensions on release of sugars from peanut roots under gnotobiotic conditions
… from the roots of peanut plants grown under gnotobiotic conditions. Seed from the peanut plant, Arachis hypogaea, L. var. NC-2 was used, Peanut embryos, with the cotyledons removed, were surface sterilized; placed aseptically into sterile plexiglass isolator chambers; and planted in …
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Effect of cereal type and commensal bacteria on availability of methionine sources and intestinal physiology in pigs
… a series of experiments using conventional and gnotobiotic pigs. At 14 d of age, sow - reared conventional (CON) pigs and isolator - reared monoassociated gnotobiotic pigs (EF) were weaned to corn or wheat/barley based diets supplemented with MET or MHA-FA. At 24 d of age, after an overnight …
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Protection of Artemia from vibriosis by heat shock and heat shock proteins
… control in aquaculture was explored, with gnotobiotic brine shrimp Artemia larvae as the model organism. The thesis contains several findings, featuring the interesting observation that a non-lethal heat shock at 37°C for 30 min followed by a 6 h recovery period and a combined …
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Quroum sensing disruption and the use of short-chain fatty acids and polyhydroxyalkanoates to control luminescent vibriosis
… the virulence of Vibrio harveyi towards gnotobiotic brine shrimp (Artemia franciscana) nauplii. Subsequently, halogenated furanones were shown to disrupt quorum sensing in these bacteria by decreasing the DNA-binding activity of the quorum sensing master regulator protein LuxR. …
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Pathogenesis and Cross-species Infection of Hepatitis E Virus
… (Ig) heavy chain knock-out JH (-/-) gnotobiotic piglet model that mimics the course of acute HEV infection observed in humans and evaluated the pathogenesis of HEV infection in this novel animal model. The dynamics of acute HEV infection in gnotobiotic pigs were systematically …
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