Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"glypican"”.
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The glypican Dally binds to Lipophorin particles and increases Hedgehog signaling efficiency
The Drosophila Lipoprotein particles bear lipid-linked morphogens on their surface and are required for long-range signaling activity of Wingless and Hedgehog. They also bind a wide variety of gpi-linked proteins. Whether any of these proteins affect morphogen signaling is unknown. Here, I show …
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Understanding the biological barriers to Jurkat Transfection using non-viral peptides
… and two kinds of membrane proteins, syndecan-4 & glypican-1. This hypothesis was verified by transfecting 5 breast cancer cell lines with different levels of syndecan-4 and glypican-1. Results from transfections and RT-PCR illustrated the correlations again.<br/><br/>Finally, an overall summary …
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Lost in Translation: Variations in WNT Signaling and Other Translational Changes in a Drosophila Model of ALS
… Among these, dlp mRNA, which encodes the glypican Dally like protein (Dlp)/GPC6, a wingless (Wg/Wnt) signaling regulator is insolubilized both in flies and patient tissues with TDP-43 pathology. While Dlp/GPC6 forms puncta in the Drosophila neuropil and ALS spinal cords, it is reduced at …
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TRANSFORMATION OF PRIMARY HUMAN HEPATOCYTES IN HEPATOCELLULAR CARCINOMA
… different cell populations compared over time. Glypican-3, Heppar-1, Arginase-1 and CD-44 positivity were tested. The degree of invasiveness of cells acquiring neoplastic characteristics was studied with a trans-well migration assay. We observed that HCC cells maintained their morphology and …
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Defining the role of heparan sulfate proteoglycans in APL-1 function in Caenorhabditis elegans
… sulfate proteoglycans (HSPGs), such as LON-2 glypican and UNC-52 perlecan, are likely candidates for the ECM proteins that interact and guide sAPL-1. The disruption of APL-1 causes phenotypical changes, including in learning, reproduction, and memory; these defects are enhanced when HSPG …
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Application of fluorescence resonance energy transfer to study syndecan-3 signaling on the surface of neural cells
… addition, I have found a new receptor for HB-GAM glypican-2 which may be involved in regulation of HB-GAM signaling by competing with syndecan-3 for ligand binding.
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Studies of the cell biological function of the Amyloid Precursor Protein (APP) family in Drosophila melanogaster and mammals
… via genetic interaction with the Drosophila Glypican Dally. Furthermore, using the Drosophila model organism, genetic interactions of the APP intracellular domain with two novel putative interaction partners, Numb and Disabled-2, were identified. The interacting domain of APP was mapped, and …
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Regulation of HPV infection and cervical cancer development following a helminth infection
… increased the expression of an HPV receptor, glypican. These data suggest that coinfec7on with N. brasiliensis has a protec7ve effect against the ini7al infec7on of HPV. Finally, to inves7gate how STH infec7on may influence the development and growth of HPVrelated cervical cancer, I developed …
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Endocytosis of therapeutic macromolecules in tumor cells - Mechanistic aspects of the proteoglycan receptor function
… classes of cell surface HS PGs, syndecans and glypicans, are true internalizing receptors capable of intracellular macromolecular delivery. This thesis advances our understanding of PGs as potential targets for macromolecular delivery vehicles. This understanding will be of aid for the …