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Showing 1 to 5 of 5 for “"glyoxylate metabolism"”.
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Glyoxylate Metabolism in Mycobacterium smegmatis
… intervention. Recently, one enzyme of the glyoxylate shunt of M. tuberculosis, isocitrate lyase (ICL), was shown to be required for virulence in experimental infections of mice. The other enzyme of the glyoxylate shunt, malate synthase (MLS), may also be important for the intracellular …
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Molecular Studies to Investigate 4-hydroxy-2-oxoglutarate Metabolism Defects of Primary Hyperoxaluria Type 3
… affecting enzymes involved in hydroxyproline and glyoxylate metabolism. Of the three PH types, the third type, PH3, is the most recently classified and least thoroughly investigated. PH3 results when mutations prevent 4-hydroxy-2-oxoglutarate aldolase (HOGA) from cleaving 4-hydroxy-2-oxoglutarate …
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Defining the role of 4-hydroxy-2-oxoglutarate aldolase in hydroxyproline metabolism and primary hyperoxaluria
Aberrant glyoxylate metabolism is a hallmark of primary hyperoxaluria (PH). PH types 1 and 2 are the consequence of functional defects in alanine-glyoxylate aminotransferase (AGT) and glyoxylate reductase (GR), respectively. The resulting increase in oxalate excretion can lead to the formation of …
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GC-MS Investigation of Metabolic Activity in 4-Hydroxy-2-Oxoglutarate Aldolase Deficiency of Primary Hyperoxaluria Type 3
… a group of three variants of an inborn error of glyoxylate metabolism. The hallmark of PH is the overproduction of oxalate which is formed from oxidation of glyoxylate by lactate dehydrogenase (LDH) and which readily crystallizes as calcium oxalate in renal tissue. PH3 is the most recently …
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HYDROXYPROLINE DEHYDROGENASE: A PROMISING TARGET FOR TREATING ALL THREE FORMS OF PRIMARY HYPEROXALURIA
… Hyperoxalurias (PH) are rare disorders of glyoxylate metabolism that cause the formation of calcium oxalate kidney stones. Currently, treatments for PH are limited. Available treatments focus on easing the symptoms of PH, not treating the disease itself. Hydroxyproline metabolism is a …