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Showing 1 to 3 of 3 for “"glyoxalase II"”.
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Nucleotide Inhibition of Glyoxalase II
The glyoxalase system mediates the conversion of methylglyoxal, a toxic ketoaldehyde, to D-lactic acid. The system is composed of two enzymes, glyoxalase I (Glo-I) and glyoxalase II (Glo-II), and exhibits an absolute requirement for a catalytic quantity of glutathione (GSH). Glo-I catalyzes the …
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The Role of Advanced Glycation End Products (AGEs) through the TRPA-1/NRF-2 Activation Pathway in the Neurodegenerative Diseases
… α-dicarbonyls are detoxified by a set of glyoxalase enzymes, glyoxalase I (GLO1) and glyoxalase II (GLO II), that are responsible for catalyzing MGO into D-lactate preventing the formation of AGEs. Therefore, preventing the formation of excessive AGE buildup is essential for limiting the …
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Metallo-β-lactamase-like enzymes from non-pathogenic organisms: an illustration of functional promiscuity
… (MBLs). MBLs are a family of Zn(II)-dependent enzymes that inactivate most of the commonly used β-lactam antibiotics. In Chapter 1 a detailed review of the properties of these enzymes is presented. Novel MBLs are continuously discovered and numerous variants of known MBLs emerge, …