Global ETD Search
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Showing 1 to 4 of 4 for “"glyoxalase I"”.
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Population Frequencies of Carbonic Anhydrase (CA II), Esterase D (EsD), and Glyoxalase I (GLO) in the Metropolitan Birmingham Area.
The identification of individual source is one of the main objectives of the forensic serologist when analyzing blood, bloodstains, or other body fluids. Certainly, the more we know about a specific blood sample, the more we can learn about an alleged criminal act. All individuality is due to …
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Design and synthesis of potential inhibitors of enzymes involved in the biosynthesis and utilisation of mycothiol
… cloning and expression of active Mycobacterial glyoxalase I, in order to generate enzymes on which to assay the synthesised molecules, are also described. Linking of the quinone functionalities to the mycothiol-like scaffold, phenyl-1-thio-Dglucosamine, was envisaged to facilitate delivery of …
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The Role of Advanced Glycation End Products (AGEs) through the TRPA-1/NRF-2 Activation Pathway in the Neurodegenerative Diseases
… α-dicarbonyls are detoxified by a set of glyoxalase enzymes, glyoxalase I (GLO1) and glyoxalase II (GLO II), that are responsible for catalyzing MGO into D-lactate preventing the formation of AGEs. Therefore, preventing the formation of excessive AGE buildup is essential for limiting the …
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Nucleotide Inhibition of Glyoxalase II
The glyoxalase system mediates the conversion of methylglyoxal, a toxic ketoaldehyde, to D-lactic acid. The system is composed of two enzymes, glyoxalase I (Glo-I) and glyoxalase II (Glo-II), and exhibits an absolute requirement for a catalytic quantity of glutathione (GSH). Glo-I catalyzes the …