Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"glycosylphosphatidylinositol (GPI)"”.
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Isolation and molecular genetic analysis of conditionally lethal yeast mutants in glycosylphosphatidylinositol anchoring
Glycosylphosphatidylinositol (GPI) anchors are a recently described class of glycolipids attached through covalent linkage to protein. To explore the functions of GPIs, I investigated the effects of GPI anchoring deficiencies in the unicellular eukaryote Saccharomyces cerevisiae.
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Solution and solid-phase synthesis of potential carbohydrate vaccines for leishmaniasis and malaria
… in the host following red blood cell rupture. A glycosylphosphatidylinositol (GPI) anchor of parasite origin was recently identified, and had the properties of a toxin. The synthesis of a modified version of the malarial GPI both in solution and on solid-phase in an automated fashion is …
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Molecular mechanisms of synaptic proteins
… were explored for MDGA1 (MAM domain-containing glycosylphosphatidylinositol (GPI) anchor 1. In the following chapters, the SAMs neurexins (NRXNs), neuroligins (NLGNs), MDGAs, and immunoglobin superfamily 21 (IgSF21) are introduced. In our studies, we characterize how the structure-function …
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Molecular mechanisms of synaptic proteins
… were explored for MDGA1 (MAM domain-containing glycosylphosphatidylinositol (GPI) anchor 1. In the following chapters, the SAMs neurexins (NRXNs), neuroligins (NLGNs), MDGAs, and immunoglobin superfamily 21 (IgSF21) are introduced. In our studies, we characterize how the structure-function …
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Development And Optimization Of The First High Throughput In Vitro Fret Assay To Characterize The Saccharomyces Cerevisiae Gpi-T
… TO CHARACTERIZE THE SACCHAROMYCES CEREVISIAE GPI TRANSAMIDASE</p> <p>By</p> <p>SANDAMALI AMARASINGHA EKANAYAKA</p> <p>December 2013</p> <p>Advisor: Dr. Tamara L. Hendrickson</p> <p>Major: Biochemistry</p> <p>Degree: Doctor of Philosophy</p> <p>The enzyme glycosylphosphatidylinositol …
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The localization of UCH-L1(Ubiquitin C-terminaHydrolase-L1) in lipid rafts of neuronal cell
… and slowness of movement. Lipid rafts enriched glycosylphosphatidylinositol (GPI)-anchored proteins, glycosphingolipid and cholresterol, are specialized microdomains that play a role in endocytosis, exocytosis, signal transduction and receptor traffic king. The disruption of lipid raft from …
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Macrophage Response to Interleukin-1 Stimulation and the Nature of Cell Surface Interleukin-1 Alpha
… through the type II IL-1 receptor (IL-1R2) and glycosylphosphatidylinositol (GPI) anchors. IL-1R2 is responsible for majority of the csIL-1α binding to the cell membrane with a small portion of csIL-1α being tethered to a GPI- associated protein. We report that csIL-1α is significantly …
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APP∙CNTN Complex Architecture is Conserved Throughout the Vertebrate Lineage
… The C-terminal FN-4 domain terminates with a glycosylphosphatidylinositol (GPI) anchor in the cell membrane; meaning that these GPI-anchored proteins have no intracellular components and thus require binding partners to communicate their interactions with other proteins on cell surfaces. CNTNs …
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Discovery of IKBKE and CD24 siRNAs for the treatment of triple-negative breast cancer
… levels of CD24, which is a heavily glycosylated glycosylphosphatidylinositol (GPI)-anchored surface protein and plays an important role in tumor growth, invasion, and metastasis. Moreover, overexpression of CD24 in tumors is associated with resistance to therapies. Small interfering RNA (siRNA) …
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Synthesis Of Functionalized Gpi Anchors And Related Glycoconjugates
… the background, significance, and synthesis of GPI anchors and GPI-anchored molecules. GPI anchors are a class of complex glycolipids with the primary purpose of attaching cell surface proteins/glycoproteins to the cell membrane. The first chapter is focused on the synthesis of functionalized …