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Showing 1 to 13 of 13 for “"glycosphingolipid"”.
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A Deuterium Nuclear Magnetic Resonance Study of Phospholipid and Glycosphingolipid Headgroup Structure
… (NMR) experiments with various phospholipids and glycosphingolipids are used to derive structural and motional information about these molecules within lipid bilayers. Reasonable models of motion are inferred from various experimental results, and calculated NMR parameters are determined for all …
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Development and application of methods for analysis of fungal glycosphingolipid structure and functional interactions
… fungal lectins, structural characterization of glycosphingolipids (GSLs) from the fruiting bodies of these mushrooms was performed. The extraction, isolation and purification of the lipids, and their subsequent characterization by nuclear magnetic resonance (NMR), mass spectrometry (MS) and gas …
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Characterization of Membrane Organization and Dynamics in Giant Unilamellar Vesicles Assembled From Rat Kidney Membrane Extracts and Fragments
… is mediated by the increased sphingomyelin and glycosphingolipid content in potassium-deficient BBM, although the mechanisms by which these lipids may modulate NaPi-IIa activity have yet to be determined.
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Glycolipids in mouse F9 teratocarcinoma cells: some changes associated with retinoic acid-induced differentiation
… F9 controls, suggesting that an enhancement in glycosphingolipid biosynthesis accompanies the differentiation of F9 cells. The monosialylganglioside-derived oligosaccharides obtained from F9 and RAlF9 cells were separated by anion exchange chromatography. A reduced biosynthesis of high molecular …
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Gaucer Disease in the Ashkenazi-Jewish Community of South Africa
… It is characterised by an accumulation of a glycosphingolipid, glycosyl ceramide in the reticulo-endothelial system. The condition presents clinically with hepatosplenomegaly, haematologic and orthopaedic problems. Affected individuals suffer from chronic ill-health and debility, with a …
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Analyzing A-series gangliosides in neurons following exposure to glutamate
… plasma membrane called gangliosides. These glycosphingolipid species have been shown to play various roles in the maintenance of neuronal viability. The purpose of this study is to use electrospray ionization mass spectrometry (ESI-MS) technique and immunohistochemistry to evaluate the …
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The localization of UCH-L1(Ubiquitin C-terminaHydrolase-L1) in lipid rafts of neuronal cell
… (GPI)-anchored proteins, glycosphingolipid and cholresterol, are specialized microdomains that play a role in endocytosis, exocytosis, signal transduction and receptor traffic king. The disruption of lipid raft from alteration of gangliosides and cholesterol content has …
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INHIBITING THE NUCLEAR RECEPTOR ESRRA RESCUES CORE PATHOLOGIES IN CELLULAR AND ANIMAL MODELS OF BATTEN DISEASE
… lab recently identified the accumulation of the glycosphingolipid Gb3 as a key pathological hallmark in multiple BD subtypes (Soldati et al., 2021). However, the underlying molecular mechanism is unknown. This thesis aims to identify the genes controlling Gb3 accumulation, paving the way for new …
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The Role of Sulfatide in Alzheimer's Disease
… domains called lipid rafts. Sulfatide (ST) is a glycosphingolipid that is essential for the proper structure and function of lipid rafts. In mice that lack ST, membrane domains that are normally maintained by adhesive contacts and functional lipid rafts are improperly formed and are unstable. In …
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Structure-Activity Studies of Glycosphingolipids as Antigens of Natural Killer T Cells
Glycosphingolipids (GSLs), composed of a polar saccharide head and a lipophilic ceramide tail, are ubiquitous components of the plasma membrane of eukaryotic cells. They serve in many regulatory capacities and have antigenic properties towards natural killer T (NKT) cells of the innate immune …
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DISSECTING THE ROLE OF GOLGI TRAFFIC IN BRAIN DEVELOPMENT ACROSS HEALTH AND DISEASE: A LESSON FROM COG5-CDG STUDIES
… its COG7 interactor. Concomitantly, reduction of glycosphingolipid (GSL) subtypes is observed. In the brain organoids of the COG5 CDG patients, an impairment on APs Golgi structure is observed. This is paralleled by changes in the apical progenitor cells division plane, that ultimately affect NPCs …
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Role of Membrane Contact Sites in the Neuropathogenesis of GM1-Gangliosidosis
… accumulation of its target substrate GM1. GM1, a glycosphingolipid found primarily in the PM of neurons, is known to modulate Ca2+ flux through its interactions with Ca2+ channels and Ca2+ binding proteins. GM1 is also known to promote neuritogenesis through the activation of phosphorylated TRKs, …
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Dissecting the Roles of Cancer Cell Lipid Metabolism in Tumor Progression and Immune Evasion
… gamma (IFNγ) signaling. Mechanistically, glycosphingolipids impact IFNγ receptor subunit 1 (Ifngr1) localization, mediating IFNγ-induced growth arrest and proinflammatory signaling. Finally, high expression of sphingolipid synthesis genes correlates with poor survival in cancer patients …