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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 138 for “"glycosaminoglycan"”.
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Glycosaminoglycan regulation of cell function
Glycosaminoglycans (GAGs) are complex polysaccharides that exist both on the cell surface and free within the extracellular matrix. The intrinsic sequence variety stemming from the large number of building blocks that compose this biopolymer leads to substantial information density as well as to …
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Regioselective Synthesis of Glycosaminoglycan Analogs
Glycosaminoglycans (GAGs), a large family of complex, unbranched polysaccharides, display a variety of essential physiological functions. The structural complexity of GAGs greatly impedes their availability, thus making it difficult to understand the biological roles of GAGs and structure-property …
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Heparan sulfate glycosaminoglycan regulation of vasculogenesis
… in stem cell differentiation. Heparan sulfate glycosaminoglycans (HSGAG) are a crucial part of the dynamic extracellular matrix and have been shown to regulate multiple signaling cascades, including vasculogenic specific growth factors VEGF and FGF. The goal of this thesis is to elucidate the …
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Permeability studies in biomimetic glycosaminoglycan-hydrogel membranes
… were studied using charged, fibrous agarose-glycosaminoglycan (GAG) membranes. The work was motivated by current research into the role of the glomerular capillary wall (GCW) in ultrafiltering blood plasma, which is the first step in the processing of blood by the kidney. The GCW is composed …
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Solid state crosslinking process for collagen-glycosaminoglycan membranes
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 1986.
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Glycosaminoglycan-protein interactions : the fibroblast growth factor paradigm
Specific interactions between heparan sulfate glycosaminoglycans (HSGAGs) and proteins are central to a wide range of biological processes such as anticoagulation, angiogenesis and growth factor activation. The specificity involved in the HSGAG-protein interactions stems from the structural …
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GLYCOSAMINOGLYCAN COATED GOLD NANOPARTICLES FOR TARGETED BREAST CANCER THERAPY
… types of cancer cells, including breast cancer. Glycosaminoglycans (GAGs), such as hyaluronic acid (HA) and chondroitin sulfate A (CSA), are known as binding ligands of CD44 receptor and were used as non-toxic targeting ligands in targeted cancer therapy. Gold nanoparticles have been demonstrated …
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Regeneration of cartilage glycosaminoglycan after degradation by interleukin-1
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2001.
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Bioinspired alterations of collagen-glycosaminoglycan scaffolds for tissue regeneration applications
… of cells in vivo and in vitro. We used charged glycosaminoglycans (found naturally in the ECM) to electrostatically sequester growth factors within the collagen matrix, preventing biomolecule degradation and presenting relevant factors to fibroblasts and mesenchymal stem cells. We showed that …
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Nitric oxide-induced DNA recombination & glycosaminoglycan mediated differentiation in stem cells
(cont.) Such therapeutic approaches require an understanding of the mechanisms regulating stem cell differentiation. The second part of this thesis investigates the role of HSGAGs in embryonic stem cell differentiation into endothelial cells. Differentiation of stem cells was accompanied by …
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Collagen-Glycosaminoglycan Scaffold Systems to Assess HL-1 Cardiomyocyte Beating and Alignment
… cardiomyoctyes in a 3D environment. Collagen-glycosaminoglycan scaffolds have been used extensively to probe the behavior of mature cells in vitro, but have not yet been designed for cardiac applications. In order to recapitulate key properties of the cardiac extracellular matrix, most notably …
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Role of interleukin-8 monomer-dimer equilibrium and glycosaminoglycan interactions in neutrophil recruitment
… (GPCR), and also bind extracellular matrix\r\nglycosaminoglycans (GAG) for recruiting target cells. Interleukin-8 (IL-8) is a proinflammatory chemokine, recruits neutrophils as a host response to infection and tissue injury.. An imbalance in the recruitment process has been attributed to a …
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Design, characterization, and reinforcement of mineralized collagen-glycosaminoglycan scaffolds for orthopedic wound repair
… This work outlines the development of a collagen-glycosaminoglycan platform that satisfies these requirements for the treatment of craniofacial defects. Chapter 2 details the fabrication and characterization of the collagen-glycosaminoglycan scaffold biochemical and biophysical properties …
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Chemokine CXCL7 Monomer, Homodimer, and Heterodimer: Structural Insights, CXCR2 Receptor Function, and Glycosaminoglycan Interactions
… activation and interactions with sulfated glycosaminoglycans (GAG) that regulate receptor activity. CXCL7 exists as monomers and dimers and there is also evidence that it could form heterodimers. Currently, nothing is known regarding the structural features of the monomer, dimer, and …
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Chemokine CXCL7 Monomer, Homodimer, and Heterodimer: Structural Insights, CXCR2 Receptor Function, and Glycosaminoglycan Interactions
… activation and interactions with sulfated glycosaminoglycans (GAG) that regulate receptor activity. CXCL7 exists as monomers and dimers and there is also evidence that it could form heterodimers. Currently, nothing is known regarding the structural features of the monomer, dimer, and …
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Development of a collagen-glycosaminoglycan analog of extracellular matrix to facilitate articular cartilage regeneration
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1998.
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