Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"glycoprotein I"”.
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Identification of Anti-Beta2 Glycoprotein I Auto-antibody Regulated Gene Targets in the Primary Antiphospholipid Syndrome Using Gene Microarray Analysis
Anti-Beta2-Glycoprotein I antibodies (anti-2GPI) are strongly associated with thrombosis in patients with primary antiphospholipid syndrome (PAPS). Anti-2GPI activate endothelial cells (EC) resulting in a pro-thrombotic and pro-inflammatory phenotype. In order to characterise EC gene regulation …
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Generation of a FHV-1 Viral Vaccine Against Gonadotropin Releasing Hormone for Immunocontraception of Felines
… In our research, we have partially replaced Glycoprotein I of FHV to express a fusion protein of Flagellin (FliC), Enhanced Green Fluorescent Protein (EGFP), and Gonadotropin Releasing Hormone (GnRH). FliC has been shown to stimulate a heightened antibody response when antigens are expressed …
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Computational investigation of membrane proteins across species and functional classes
… the membrane-binding mechanism of human beta-2-glycoprotein I, revealing key electrostatic and hydrophobic interactions that drive anionic lipid recognition and identifying a previously unreported lipid-interaction site within its membrane-binding domain. I then explore substrate binding in …
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Dissecting the Molecular Basis of the Antiphospholipid Syndrome
… deprivation of the cell surface protein beta 2 glycoprotein I (beta 2GPI) from endothelial cells prevents aPL inhibition of eNOS, and that FC1, a monoclonal antibody against beta 2GPI, mimics the effects of aPL. Receptor-associated protein or RAP, an antagonist of the LDL receptor (LDLR) family, …
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Analisi proteomica quantitativa del fluido lacrimale per la diagnosi e la terapia farmacologica della Vernal Keratoconjunctivitis
… esperimenti: apolipoprotein A-I e alpha 1-acid glycoprotein. I risultati, dunque, sono stati positivi per entrambi i trattamenti ed hanno confermato l efficacia di tali farmaci per la gestione delle fasi attive della patologia in quanto consentono un buon controllo dei sintomi della VKC ed in …
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Advancing RNA Virus Discovery and Biology with Whole Genome Sequencing
… were identified within the nucleocapsid and glycoprotein. I observed several amino acid changes in functional domains of the RNA-dependent RNA polymerase, as well as single nucleotide polymorphisms (SNPs) within the 3’ non-coding region (NCR) of the S-segment. To identify whether virus …
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Studies of viral and cellular proteins involved in herpes simplex virus type-1 egress
… by co-ordinated activity of several virus glycoproteins. The virions are first assembled and enveloped at trans-Golgi-network (TGN) or endosome membranes and then travel through a guided pathway that is directed towards the cell adherent points for secretion. Once secreted the vast majority …
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Proteomic analysis of the sorting machineries involved in vesicular traffic between the biosynthetic and endosomal compartments
… (MPRs) (Ghosh et al., 2003) or the gpI envelop glycoprotein of the Vesicular Zoster virus (Alconada et al., 1996), while sorting of lysosomal membrane proteins like Lamp-1 and LimpII is AP-3 regulated (Eskelinen et al., 2003). To study how AP-1A and AP-3 coats are stabilized on membranes and to …