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Showing 1 to 14 of 14 for “"glycopolymers"”.
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Branched Glycopolymers
Linear and branched glycopolymers of a sugar-carrying acrylate monomer, 3-O-acryloyl-1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose (AIGlc), were synthesized via atom transfer radical polymerization (ATRP). Self-condensing vinyl copolymerization (SCVCP) via ATRP was employed for the synthesis of …
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Surface Modification of Spherical Particles with Bioactive Glycopolymers
Glycopolymers containing different kinds of carbohydrates were grafted from various spherical templates, whereby the glycopolymer chains were prepared via controlled radical polymerization techniques, namely ATRP and RAFT. A library of carbohydrate-displaying spheres and their interaction with …
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Thermoresponsive Glycopolymers via Controlled Radical Polymerization (RAFT) for Biomolecular Recognition
… at ~ 32° C in aqueous solution. Additionally, glycopolymers, where free sugar units are present, have potentially interesting applications especially in bio-recognition where sugars play an important role. In this work, our interest was focused on the synthesis of glycomonomers and its block- …
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Cationic Glycopolymers for DNA Delivery: Cellular Internalization Mechanisms and Biological Characterization
Understanding the biological mechanisms of polymeric DNA delivery is essential to develop vehicles that perform optimally. In this work, the cellular internalization mechanisms of poly(glycoamidoamine) (PGAA) DNA delivery polymers were investigated. Polymer:DNA complexes interact with cell-surface …
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Development of Carbohydrate-based Diblock Polymers for Nucleic Acid Delivery
… acid delivery vehicles based on cationic diblock glycopolymers that contain glucosamine and trehalosamine. Practical procedures were developed to synthesize 2-methacrylamido-2-deoxy glucose and 6-methacrylamido-6-deoxy trehalose starting with commercially available carbohydrates and utilizing …
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Design, Synthesis, and Characterization of Glycodendrons Through Small Molecule and Linear Polymer Models
… overview of the importance and applications of glycopolymers, bioimaging, and Janus dendrimersomes. The second chapter presents the synthetic methods for creating a glucose-functionalized glycopolymer with an acrylamide backbone, the exploration of thiol-ene coupling reaction conditions for …
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Synthesis and Characterization of Polymeric Materials as Sequestrants for Biological Applications
… properties observed with unmodified glycopolymers by increasing glycan density to inhibit bacterial growth and separately, introducing cationic charges to disrupt bacterial membranes. Our approach used the oxo-norbornene derivative, a key procedural change as these materials are not …
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SYNTHESIS AND CHARACTERISATION OF NOVEL BIOPOLYMERS VIA CLICK CHEMISTRY
… of Click chemistry to produce trehalose-based glycopolymers which have a wide range of potential applications. Biodegradable glycopolymers containing PCL or PLA were synthesised via combination of ring opening polymerisation (ROP) and Click chemistry. The ROP of lactide and ε-caprolactone, …
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New inverse opal hydrogels as platform for detecting macromolecules
… but also for large analytes, such as glycopolymers or proteins. This enables the PhC to act as a sensor that detects analytes without the need of complex equipment. Due to their periodical dielectric structure, PhCs prevent the propagation of specific wavelengths. A change of the …
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Assembly and Display of Surface Proteins In Actinomyces Oris
… proteins are modified by the addition of glycopolymers, and I characterized a phosphotransferase enzyme with a novel role in protein glycosylation. These studies contribute to the understanding of the role of <em>A. oris</em> as a primary colonizer in the oral biofilm. Additionally, using …
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Engineering the future of Hybrid Materials with Coarse-Grained Molecular Dynamics
… such as carbohydrate-protein binding dynamics in glycopolymers, by using CG MD simulations to decode structure-function relationships that govern molecular recognition and interaction efficiency. These simulations showcase the significance of factors such as glycan density in enhancing solvent …
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Serum Stable Carbohydrate-Oligoethyleneamine Copolymers for Nucleic Acid Delivery
… via dynamic light scattering (DLS). The glycopolymers were tested for pDNA binding, toxicity, cellular uptake, and transfection efficiency in vitro. Characterization of these polymers revealed a significant influence of minor structural modifications on bioactivity. In general, all of the …
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Synthesis and application of specifically sulfated carbohydrates containing methacrylate functionality
… find wide utility for development of novel glycopolymers for biomedical applications including drug delivery.