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Showing 1 to 20 of 37 for “"glycopeptides"”.
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Unnatural glycopeptides with application on cancer research
… focus on the study of two important classes of O-glycopeptides with relevant implications to fight against cancer: mucins, such as mucin-1 (MUC1), and antifreeze glycoproteins. Concerning the first mentioned class, mucins are a family of O-glycoproteins with high molecular weight that serve as …
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Antifreeze Peptides and Glycopeptides in Polar Fishes
… with the relationship of antifreeze peptides and glycopeptides to the processes of osmoregulation and reproduction in polar fishes. Polar fishes, like many marine teleosts, have serum osmolalities which are lower than that of sea water. As a result of being hypoosmotic to sea water, marine fishes …
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Structure-guided Cancer Vaccines based on Glycopeptides Supported on Diverse Nanoparticles
… in this work the synthesis of different MUC1 glycopeptides with modifications in the Arg residue and their comparison in terms of affinity towards the SM3 anti-MUC1 monoclonal antibody to select a vaccine candidate among them.
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Structure-based design of unnatural glycopeptides for cancer diagnosis and therapy
En esta tesis se han desarrollado glicopéptidos no naturales de MUC1 utilizando un diseño racional basado en estructura. Este trabajo se ha apoyado en datos previamente reportados con el fin de mejorar la afinidad de estos derivados in vitro con anticuerpos bien estudiados, incorporando sustitutos …
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Antifreeze Glycopeptides of Antarctic Fish: Comparative Aspects of Their Biochemistry and Physiology
The presence of antifreeze glycopeptides (AFGPs) in the blood of polar fishes allows fish to live in ice-laden seawater at a temperature below what colligative properties would dicate to be the freezing point of their blood. AFGPs are well-characterized from two antarctic species, Pagothenia …
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Mass Spectrometry Studies on the Dissociation of Metal-Adducted Oligosaccharides, Glycopeptides, and Fatty Acids
Analyzing oligosaccharides, glycopeptides, and fatty acids poses a significant analytical challenge due to their structural complexity and diversity. Structural alterations in these biomolecules have direct implications for health and diseases, necessitating the development of analytical methods …
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Structure-based design of glycopeptides featuring unnatural tn antigens and their applications to cancer vaccination and diagnosis
El objetivo principal de la presente tesis doctoral es el estudio conformacional del antígeno Tn, ya sea solo o incluido en el esqueleto peptídico de la mucina MUC1. Conocer la estructura de este tipo de glicoproteínas es clave para poder mejorar su interacción con moléculas de interés biológico, …
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Ring-Opening of Aziridine -2 -Carboxamides by Carbohydrate C1-O Nucleophiles. Stereoselective Preparation of O-Linked Glycopeptides
A new method for the synthesis of O-linked glycopeptides is described. The method uses the carbohydrate C1-O nucleophilic ring-opening of aziridine-2-carboxamides to access the target O-linked glycopeptides. The synthesis of the alpha-GalNAc-Ser class of glycopeptides is emphasized and either the …
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Beta-o-glicosilación de péptidos que incorporan aminoácidos no naturales
… acids and their corresponding model beta-O-glycopeptides, are reported. From this study, it can be concluded that the incorporation of non-natural amino acids allows us to modulate as desired the conformational space of the model glycopeptides. The different conformations exhibited by these …
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Síntesis y análisis conformacional de glicopéptidos que incorporan ß-glucosa y a-N-acetilgalactosamina
… which comprises the study of carbohydrates, glycopeptides and glycoproteins, has attracted considerable attention due to these molecules are involved in many fundamental processes of the life. One of these processes is known as molecular recognition of ligands by receptors. In particular, …
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GLYCOPEPTIDE ANALYSIS OF HIV-1 ENVELOPE PROTEIN USING HPLC/ESI-FTICR MS AND MALDI-TOF MS WITH ASIALOFETUIN ENRICHMENT AND SEPARATION TECHNIQUES
… exhibits. Methodologies in characterization of glycopeptides often include a proteolytic digest followed by purification of the digested protein with liquid chromatography. Mass spectrometers are sensitive to salts and buffer contents, thus a purification of the sample before analysis is vital …
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Synthesis of mannosylated peptides as components for synthetic vaccines
… was introduced into the glycopeptides via the Nα- or the Nε-amino group of the lysine residue. It was found that preparation of the glycopeptide was more facile when the peptide chain was built onto the Nε of Lys (label into Nα) rather than onto the Nα of Lys (label into …
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Post-translational modifications of SEL24K from salmon eggs and ZPA from Xenopus laevis eggs
… excised band of ZPA to produce informative small glycopeptides. Lectin affinity chromatography was used for the enrichment of these glycopeptides. An in-gel PNGase F digestion was also carried out to release the N-linked glycans from ZPA. The enriched glycopeptides and glycans were finally …
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Hemmung der Eisrekristallisation in wässrigen Lösungen durch Antigefrierglykopeptide
… especially for antifreeze glycoproteins and glycopeptides (AFGP), which are present in some fish of the polar oceans. Therefore, within the present work several substances were investigated that inhibit the ice growth similar to AFP and AFGP. The efficiency of this growth inhibition was …
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Improving reproducibility and standards in quantitative N-Glycoproteomic data
… the availability and compatibility of data. N -Glycopeptides can be identified in tandem mass spectrometry data, but this is with greater uncertainty than traditional proteomics for a variety of factors. This uncertainty propagates into the quantification of these molecules, generating …
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I. Efforts Toward the Total Synthesis of (-)-Crambidine. II. Reactions of Azy(3-Me)-Containing Peptides With Thiols and Selenols
… of electrophilic peptide residues, two S-linked glycopeptides were successfully synthesized. Benzeneselenol was found to be highly reactive with Azy(3-Me)-containing peptides, and a variety of synthetically useful selenopeptides have been generated.
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Synthesis Of Functionalized Gpi Anchors And Related Glycoconjugates
… we synthesized several CD52 peptides and glycopeptides and compared their conformational profiles using circular dichroism. This work, as well as brief introductions to N-glycosylation, the CD52 antigen, and chemical synthesis of glycopeptides are discussed the second chapter.</p> <p>Both …
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Oligomers of beta-L-arabinosides of hydroxyproline : synthesis of the carbohydrate epitope of the Art v 1 allergen
… 48%, 35%, and 15% respectively. The end-capped glycopeptides could then be fully deprotected by global debenzylation to give the final products in quantative yield. Circular dichroism spectra were obtained for the synthetic glycopeptides. Analysis of the CD spectra showed that the glycosylated …
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Preparation of Dehydropeptides and Their Application in the Convergent Synthesis of Peptide Conjugates
… a number of other lipid peptides and S-linked glycopeptides were prepared through the Michael addition of corresponding thiolates to dehydropeptides. Furthermore, the preparation of dehydropeptides and the Michael addition were also illustrated to be compatible with solid phase.
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