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Showing 1 to 6 of 6 for “"glycomimetic"”.
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SELECTIVE GLYCOMIMETIC LIGANDS OF C-TYPE LECTIN RECEPTORS
… properties. In this thesis we disclose a glycomimetic approach to selectively target the C-type lectin DC-SIGN and its homologue L-SIGN, which are involved in the recognition of several viruses (e.g. HIV-1, Ebola, Dengue, SARS-CoV-2). A library of monovalent mannose-based glycomimetic …
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GLYCOMIMETIC LIGANDS TARGETING BACTERIAL LECTINS: RATIONAL DESIGN, SYNTHESIS AND BIOPHYSICAL EVALUATION
… In previous work, a collection of bifunctional glycomimetics specifically targeting the N-terminal domain of BC2L-C (referred to as BC2LCNt) was discovered using a combination of fragment- and structure-based design methods. The synthesized first-generation ligands consisted of a L-fucose core …
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Synthesis of small-molecule HGF-Met inhibitors for use in preventing cell motility
… (3 step) mono, di-, tri- and tetra-sulfated glycomimetic compounds for their use in preventing HGF-induced cell motility in cancers, prevention of Met activation and for their beneficial actions in assisting wound healing. Glycosaminoglycans are becoming more and more focused upon as a …
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Establishing a structure-activity-relationship for small molecule non-sugar glycomimetics
… (2017) showed that some small-molecule non-sugar glycomimetic drugs were able to prevent wound healing in DAOY cells. Therefore establishing a SAR for these molecules was of interest.A number of mono, di, tri, tetra & poly-sulfated drug molecules were synthesised from easily available starting …
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Effiziente Konformationsanalyse von Peptiden
… The determination of the structures of glycomimetic cyclic hexapeptides contributes to understanding the basis of the mimicry of the L2/HNK1 epitope, a carbohydrate structure with several important functions, in particular in the peripheral nervous system. The structures of cyclic penta- …
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Reductive Alkylation of Proteins Towards Structural and Biological Applications
… to impact leading research today including glycomimetics and cross-linking of proteins. Current protein chemical modifications like polyethylene glycol are proven useful for increasing the lifetime of several therapeutic enzymes but are also toxic to the body. In the last chapter, we present …