Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 299 for “"glycolysis"”.
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Investigation of glycolysis in Bacillus subtilis
Bacillus subtilis ist ein Modellorganismus für Gram-positive Bakterien mit Relevanz für die Biotechnologie. Die intensive Erforschung dieses Bakteriums macht es zu einem der am besten untersuchten Prokaryonten im Bereich der Molekular- und Zellbiologie. Obgleich dieses Bakterium gut untersucht ist, …
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Mechanical Regulation of Glycolysis via Cytoskeleton Architecture
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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The Role of Aerobic Glycolysis in the Resting Human Brain
… some fraction of glucose undergoes aerobic glycolysis without concomitant oxidative phosphorylation. Elevation in neuronal activity increases aerobic glycolysis due to the disproportionate increase in blood flow and glucose utilization greater than oxygen consumption. Since aerobic …
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Coordinated regulation of glycolysis and the folate one-carbon cycle
… other proliferating cell types exhibit "aerobic glycolysis" characterized by elevated glucose uptake and conversion of glucose to lactate even in the presence of oxygen. Aerobic glycolysis is associated with anabolic reactions to generate new cellular material, but how aerobic glycolysis supports …
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DIFFERENTIAL EFFECTS OF GROWTH FACTORS ON GLYCOLYSIS IN OVARIAN CANCER CELLS
… oxidative phosphorylation to aerobic glycolysis, a phenomenon described by Otto Warburg nearly a century ago. This seems to be necessary to meet bioenergetic and biosynthetic demands of rapidly dividing tumor cells. However, the mechanism underlying the switch from aerobic respiration …
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Low Reactive Oxygen Species and High Glycolysis In Glioblastoma Stem Cells:Mechanisms and Therapeutic Implications
… Additionally, GSCs showed high dependence on glycolysis for energy production. The combination of a glycolytic inhibitor 3-BrOP and a chemotherapeutic agent BCNU depleted cellular ATP and inhibited the repair of BCNU-induced DNA damage, achieving strikingly synergistic killing effects in drug …
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Novel Functions of Cetuximab In Egfr-Targeted Therapy: Radiosensitization, Glycolysis Inhibition, and Cellular Redox Status Regulation
… and discovered novel functions of cetuximab in glycolysis inhibition and cellular redox status regulation. We found that cetuximab inhibits radiation-induced hypoxia inducible factor 1 (HIF-1), which is required for the radiosensitization role of cetuximab. We also found that cetuximab inhibits …
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Nitrite and insulin lower the oxygen cost of ATP synthesis in skeletal muscle cells by pleiotropic stimulation of glycolysis
… of a mitochondrial uncoupler, suggesting that glycolysis is increased directly. In myoblasts, stimulation is annulled by uncoupler, suggesting that glycolysis increases indirectly, via increased ATP consumption. The molecular targets of nitrite and insulin remain unclear, but the data exclude …
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Different Effect of 5-Fluorouracil on Expression of Genes Related to Aerobic Glycolysis According to Chemoresponsiveness in Gastric Cancer Cells
… cancer to 5-FU might be related to the aerobic glycolysis pathway which depends on the hypoxia-inducible factor 1α (HIF 1α). I investigated HIF1α expression and responsiveness to 5-FU in two different types of gastric cancer cells (MKN45, SNU216). In addition, we checked the …
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A simple coarse-grained model to predict infectious disease outbreak statistics and the consequences of glycolysis inhibition on cell junction mechanics
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-03-28 without embargo terms
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Regulation of Akt ignal transduction by glucose metabolism
Aerobic glycolysis is carried out at an inordinately high rate in cancer cells, a phenomenon known as the Warburg effect. While the relevance of this effect is unclear, it is partly driven by upregulation of the glycolytic enzyme 6‐phosphofructo‐2‐kinase/fructose‐2,6‐biphosphatase 3 (PFKFB3). …
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유전자 적중법을 이용한 조건적 LDHB 유전자 삭제 마우스 제작
… metabolism. Normal cells produce 2 ATP by glycolysis in the cytoplasm and convert to 2 pyruvates. Next, this pyruvate produces about 36 ATP by oxidative phosphorylation in the mitochondria. On the other hand, many metastatic cancer cells have altered glycolytic(glucose) metabolism. The …
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UNDERSTANDING THE MOLECULAR MECHANISM LINKING ATM TO METABOLIC REGULATION.
… manifestations. Here we show that ATM activates glycolysis upon oxidative stress and that its loss leads to impairment of glycolysis and impairment of metabolism in A-T cells. In addition, we identified a metabolic regulator as a major driver of glycolysis impairment and poor cell growth in A-T …
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Disassembly of electron transport chain complexes drives macrophage TLR responses by reprogramming metabolism and translation
… from oxidative phosphorylation (OxPhos) to glycolysis is a key feature of inflammatory response in macrophages, but how this switch occurs in response to inflammatory signals and how it precisely contributes to macrophage function is still obscure. Here we show that stimulation of …
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The Regulation of Glucose Metabolism during Osteoblast Differentiation
… conditions, a phenomenon known as aerobic glycolysis. However, the significance of increased aerobic glycolysis for bone formation was not known. Based on the link between metabolic abnormalities and the genetic mutations in WNT pathway components, I hypothesized that WNT regulates cellular …
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ROLE OF LYSOPHOSPHATIDIC ACID IN REGULATION OF CANCER CELL METABOLISM
… of hyperactive de novo lipogenesis and aerobic glycolysis, two hallmarks of cancer cells. We demonstrated that LPA induced proteolytic activation of sterol regulatory element binding proteins (SREBPs) in a cancer specific manner, leading to activation of the SREBP-FAS (fatty acid synthase) …
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Chemical recycle of polyester waste using novel zwitterionic catalysts
… in the presence of ethylene glycol viaglycolysis to give bis(hydroxyethyl)terephthalate (BHET). The influence ofreaction temperature, glycolysis time, ethylene glycol:PET ratios, and theamount of the zwitterionic imidazolium-2-carboxylate catalysts used on theconversion of PET, isolated …
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The effects of the modification of energy metabolism on cellular response to ionizing radiation
… glutamine which are initially metabolised via glycolysis and glutaminolysis, respectively, before their products are further metabolised in respiration. Since energy is necessary for repair of radiation damage, it has been proposed that the inhibition of energy metabolism might alter the …
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