Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"glycolipids"”.
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Axonal Transport of Glycoproteins and Glycolipids in the Goldfish Optic System
<p>The goldfish retino-tectal pathway is a convenient experimental system for studying axonal transport. Radioactive precursors are injected into the eye, and radioactivity which is transported in the axons of the retinal ganglion cells can be studied as it moves in the optic nerve and optic tract …
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The Synthesis of Amphiphilic Glycolipids as Potential Inhibitors of Bacterial Adhesion
The synthesis of glycolipids as potential anti-bacterial agents and glycolipid mimetics is the main focus of the research presented in this thesis. A variety of glycolipids based around an aspartic acid, aliphatic or aromatic scaffold were investigated. Chapter 1 describes the biological importance …
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Affinity purification of blood group A-active glycolipids on immobilized Helix pomatia lectin
… has not been used for the separation of glycolipids since mixtures of these compounds form micelles in aqueous solution. Since N-acetylgalactosamine (GalNAc) is commonly found in glycolipids, three GalNAc-specific lectins were selected to develop a lectin affinity chromatographic method …
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Glycolipids in mouse F9 teratocarcinoma cells: some changes associated with retinoic acid-induced differentiation
… [6-3H]galactose or [6-3H]glucosamine, and their glycolipids were compared. The neutral and acidic glycolipid fractions from both cell lines were subjected to ozonolysis and alkali fragmentation or endoglycoceramidase digestion to release the glycolipid-derived oligosaccharides. The neutral …
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Synthesis of glycolipids inspired by Fucus distichus and natural product isolation and characterization of Euphorbia lancifolia
… family of analogues explored includes C-linked glycolipids, where a carbon-carbon linkage replaces the metabolically unstable C-O ester bond between the sugar and the glycerol in the natural product. The natural product, as well as eight other analogues were synthesized. Bioactivity data for …
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Synthetic Alkyl Glycolipids as Therapeutic Agents: Their Synthesis as Potential iNKT Cell Stimulators and their Anti- Microbial Properties
… reported in this thesis is the synthesis of glycolipids for anti-microbial studies and to act as iNKT cell stimulatory ligands. Simple glycolipids, L-aspartic acid based glycolipids, glycoglycerolipids and L-serine based glycolipids were explored. Simple galactosyl glycolipids containing O- …
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Structural analysis of glycolipid-derived oligosaccharides from metabolically radiolabelled colorectal carcinoma SW1116 cells
… recovered in the glycoconjugates corresponded to glycolipids when cells were labelled with 6-[³H]-D-galactose, and about 12% when cells were radiolabelled with 6- [³H]-D-glucosamine. Metabolically radiolabelled glycolipids were separated into neutral (88-91% of the radioactivity recovered in …
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Cytosolic sphingolipids and lysosome reactivation in neurodegenerative diseases
… Chapter1 firstly summarizes the synthesis of glycolipids and their transportation to lysosomes for degradation and recycling back into the Golgi; however, in the case of LSDs, this is defective. Furthermore, it discusses how impaired endolysosomal acidification and lipid imbalance can be …
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Isolation and molecular genetic analysis of conditionally lethal yeast mutants in glycosylphosphatidylinositol anchoring
… (GPI) anchors are a recently described class of glycolipids attached through covalent linkage to protein. To explore the functions of GPIs, I investigated the effects of GPI anchoring deficiencies in the unicellular eukaryote Saccharomyces cerevisiae.
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Chemical Probes and Strategies to Study Mycobacterial Cell Envelope Assembly
… to probe arabinogalactan and mannose-containing glycolipids. Building upon prior work using lipid-linked probes to label mycobacterial arabinan, Chapter 2 details the development of azido-functionalized farnesyl phosphoryl mannose (AzFPM) probes that mimic native polyprenyl-phosphoryl donors and …
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Organic geochemical biosignatures in alkaline Hydrothermal ecosystems
… from Lost City shows that most are ether-type glycolipids. The dominance of glycolipids over phospholipids may be a phosphorus-conservation strategy in waters that are likely phosphorus-poor. Ether core lipids are similar to those produced by sulfate-reducing bacteria in environments where …
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Constituents of Ipomoea pes-caprae L. R. Br.
… of β-sitosterol and a complex mixture of glycolipids. Two components of the glycolipid mixture were characterized as β-rhamno-pyranosyl-11-hydroxyhexadecanoic acid and β-fucopyranosyl-11-hydroxyhexadecanoic acid. In addition, the plasticizer bis-(2-ethylhexyl)phthalate was identified as a …
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Diabetic foot: microbiology, pathogenesis and glycan studies
… on whole cells, Proteinase K treated cells and glycolipids of clinically significant aerobes and anaerobes. This study is concluded by utilising the glycan-lectin interactions and to develop a rapid typing method for clinically significant Methicillin resistant and sensitive Staphylococcus …
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TUMOR-PROMOTING FUNCTION AND MOLECULAR REGULATION OF TSPAN8 IN LIVER CANCER
… N-glycans and synthesis of lacto-series glycolipids mediated by a SPPL3/B3GNT5 axis are important for cell surface presentation of TSPAN8 and other tetraspanins. Collectively, our findings unmasked the potential of TSPAN8 as a diagnostic biomarker and therapeutic target in liver cancer …
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The Synthesis of Glucosamine-Based Derivatives with Potential as Immunomodulators, Kinase Inhibitors, and Prodrugs
… the synthesis of novel glucosamine-based serine glycolipids, which were tested for their immunomodulatory ability. The experimental conditions investigated are discussed in detail. Chapter 3 describes the synthesis of a glucosamine-based serine building block, and its incorporation into a series …
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Staphylococcal Enterotoxin B-Induced Acute Lung Injury:Mechanism and Treatment of Disease
… previously were shown to be only stimulated by glycolipids, can also get activated by a protein antigen, SEB; therefore directly contributing to severe respiratory failure. In addition, we show that upon SEB inhalation, not only the capillaries but also the terminal vessels of the lungs undergo …
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Natural killer T cell subsets and regulation of autoimmune diabetes
… (NK) T cells. NKT cells recognize lipids and glycolipids, rather than peptides, in the contents of the antigen presenting molecule CD1d. NKT cells have a surface phenotype reminiscent of memory cells, and have been shown to rapidly produce large amounts of cytokines, such as IL-4 and …
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A role for a predicted E. coli inner membrane lipoprotein in cell envelope integrity
… membrane is composed of phospholipids, glycolipids, and proteins. A large portion of the bacterial cellular proteome is composed of membrane proteins. Despite this, the functions of several membrane proteins are as yet undefined. Therefore, defining the physiological roles of …
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CD1d restricted NKT cells in regulation of pathogenic autoimmunity
… molecule CD1d have so far been identified as glycolipids originating from either bacteria or self. This thesis investigates the role of NKT cells in autoimmune tissue-specific inflammation. We found that NKT cells can down-regulate both the central nervous system-specific autoimmunity in EAE, …
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