Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"glycolipid"”.
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Synthesis of Novel Glycolipid Agonists of the Protein CD1d
… cells recognise a range of foreign lipids and glycolipids bound to CD1d proteins. \(\alpha\) \(\beta\)-Galactosyl Ceramide (\(\alpha\) \(\beta\)GalCer), originally isolated from a marine sponge, is a powerful agonist of CD1d capable of triggering an immune response that results in the …
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Structural analysis of glycolipid-derived oligosaccharides from metabolically radiolabelled colorectal carcinoma SW1116 cells
… recovered in the glycoconjugates corresponded to glycolipids when cells were labelled with 6-[³H]-D-galactose, and about 12% when cells were radiolabelled with 6- [³H]-D-glucosamine. Metabolically radiolabelled glycolipids were separated into neutral (88-91% of the radioactivity recovered in …
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Glycolipids in mouse F9 teratocarcinoma cells: some changes associated with retinoic acid-induced differentiation
To investigate the changes in glycolipid biosynthesis during early embryogenesis mouse F9 teratocarcinoma cells were induced to differentiate in vitro in the presence of retinoic acid. Control embryonal carcinoma cells and their differentiated derivatives, RNF9 cells, were …
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Affinity purification of blood group A-active glycolipids on immobilized Helix pomatia lectin
… has not been used for the separation of glycolipids since mixtures of these compounds form micelles in aqueous solution. Since N-acetylgalactosamine (GalNAc) is commonly found in glycolipids, three GalNAc-specific lectins were selected to develop a lectin affinity chromatographic method …
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Mycobacterium tuberculosis Lipids Activate Neurons and Trigger Cough
… cough is unknown. Here, I identified the Mtb glycolipid sulfolipid-1 (SL-1) as a nociceptive-activating and cough-inducing molecule. I also demonstrated that phenolic glycolipid (PGL), which is uniquely produced by the hypervirulent Mtb HN878, activates nociceptive neurons. Finally, I …
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Synthesis of glycolipids inspired by Fucus distichus and natural product isolation and characterization of Euphorbia lancifolia
… molecule from this seaweed was identified as a glycolipid consisting of beta- D-galactose linked to two o-linolenic acid chains via a glycerol unit. The synthesis of this glycolipid, as well as a number of derivatives, is described to investigate their antibiotic and antiviral activity relative …
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A Bottom-Up Approach to Building an Artificial Cell by Self-Assembly
… modification, there is growing interest in using glycolipids to fulfil a molecular recognition role. A synthetic glycolipid has been incorporated into the phospholipid membrane of giant unilamellar vesicles at biologically relevant concentrations. The synthetic glycolipid shows …
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Constituents of Ipomoea pes-caprae L. R. Br.
… of β-sitosterol and a complex mixture of glycolipids. Two components of the glycolipid mixture were characterized as β-rhamno-pyranosyl-11-hydroxyhexadecanoic acid and β-fucopyranosyl-11-hydroxyhexadecanoic acid. In addition, the plasticizer bis-(2-ethylhexyl)phthalate was identified as a …
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Uncovering Novel Mechanism of Immune Modulation of Invariant Natural Killer T Cells By Liposomal Α-Galactosylceramide
… </sup>and CD8α<sup>+</sup>), they recognize glycolipid antigens via the MHC-class-I like molecule, CD1d. A synthetically derived glycolipid from the marine sponge, <em>Agelas mauritianus</em>, alpha-Galactosylceramide (α-GalCer) potently activates iNK-T cells. Within a few hours after …
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The Synthesis of Amphiphilic Glycolipids as Potential Inhibitors of Bacterial Adhesion
The synthesis of glycolipids as potential anti-bacterial agents and glycolipid mimetics is the main focus of the research presented in this thesis. A variety of glycolipids based around an aspartic acid, aliphatic or aromatic scaffold were investigated. Chapter 1 describes the biological importance …
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LECTINS FROM THE HORSESHOE CRAB, LIMULUS POLYPHEMUS, REACTIVE WITH BACTERIAL LIPOPOLYSACCHARIDE
… and chicken erythrocytes coated with glycolipid from the Re mutant of S. minnesota indicated that the isolated lectin reacts with both N-acetylneuraminic acid and KDO. Cross-inhibition studies suggest that the same combining site on the lectin is involved in these reactions.</p>
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Cell Wall Lipids Promoting Host Angiogenesis During Mycobacterial Infection
… PcaA-modified trehalose dimycolate, an abundant glycolipid in the mycobacterial cell wall, drives activation of host VEGF signaling and subsequent granuloma vascularization. To facilitate our continuing investigation of granuloma dynamics, we next sought to expand and improve upon the transgenic …
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Preparation of Substituted Enol Derivatives from Terminal Alkynes and Progress Toward the Total Synthesis of Nigricanoside A
… of nigricanoside A, a potent antimitotic glycolipid isolated from marine green algae. A convergent synthetic route is presented along with an analysis the natural product’s relative and absolute stereochemistry. Various diastereomers of orthogonally protected subunits of nigricanoside A …
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Human brain lipid fatty acid composition in relation to infant diet
… the cerebrum. Analysis of the phospholipid and glycolipid composition of the cerebral and cerebellar white matter tissues was achieved by means of separation by high performance thin layer chromatography followed by scanning densitometry. The results of this study support the need for breast …
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Characterization of Alpha-Galactosylceramide As A Mucosal Adjuvant
… in support of the effectiveness of a synthetic glycolipid, alpha-Galactosylceramide (-GalCer), as an adjuvant for mucosal immunization with peptide and protein antigens, by oral and intranasal routes, to prime antigen-specific immune responses in multiple systemic and mucosal compartments. The …
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Characterisation of the immunomodulatory properties of human natural killer T cells
… receptor and NK surface molecules and recognize glycolipid antigen presented by CD1. iNKT cells have shown potent anti-tumour properties when stimulated with the iNKT cell agonist α-galactosylceramide (αGalCer) in murine models. However iNKT cell based immunotherapies have proved disappointing in …
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Investigating The Role of Il-10 Producing Nkt Cells In Prevention of Graft Versus Host Disease
… cells are unconventional T cells which recognize glycolipid antigens presented in the context of CD1d. Upon activation, they secrete cytokines according to the functional subtypes NKT1, NKT2, NKT10, and NKT17. The distinct cytokines released by each subtype modulate the response by conventional T …
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Synthetic Alkyl Glycolipids as Therapeutic Agents: Their Synthesis as Potential iNKT Cell Stimulators and their Anti- Microbial Properties
… reported in this thesis is the synthesis of glycolipids for anti-microbial studies and to act as iNKT cell stimulatory ligands. Simple glycolipids, L-aspartic acid based glycolipids, glycoglycerolipids and L-serine based glycolipids were explored. Simple galactosyl glycolipids containing O- …
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