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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"glycolate"”.
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Synthesis of Resveratrol and Its Analogs, Phase-Transfer Catalyzed Asymmetric Glycolate Aldol Reaction, and Total Synthesis of 8,9-Methylamido-Geldanamycin
… catalysts (PTC) were developed for glycolate aldol reactions to give differentially protected 1,2-diol products. Silyl enol ether of diphenylmethoxy-2,5-dimethoxyacetophenone reacted to generate benzhydryl-protected products. O-Allyl trifluorobenzyl cinchonium hydrodifluoride (20 mol …
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Studies in Asymmetric Catalysis: Lewis Base Catalyzed, Enantioselective Addition of Trimethylsilyl Cyanide, Trimethylsilyltrifluoromethane, and Glycolate-Derived Silyl Ketene Acetals to Aldehydes
… catalyst is effective for the addition of glycolate-derived silyl ketene acetals to aldehydes. The sense of diastereoselectivty could be modulated by changing the size of the substituents on the silyl ketene acetals. In general, the trimethylsilyl ketene acetals derived from methyl …
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ANALYSIS OF ANIONS AND PROTEINS RELATED TO OXALATE METABOLISM IN HUMAN ERYTHROCYTES
… their co-elution. Erythrocyte incubations with glycolate, glyoxylate, and C-13 glycolate were used to study whether these acids were precursors of oxalate or phosphoglycolate. This study also assessed a more costeffective and less-invasive diagnostic assay called Dried Blood Spot Filter Paper …
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Bacterial community composition in stream biofilms is influenced by algal response to varying light and phosphorus ratios
… bacterial portion of the microbial community. Glycolate is an algal-specific exudate produced under excess light conditions. Glycolate uptake by bacteria has been shown to correlate with algal primary productivity. Bacterial populations that utilize glycolate possess the gene, glycolate oxidase …
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Investigating exudate- and habitat-mediated effects of phytoplankton on lake bacterial community dynamics
… to use the photorespiration-specific exudate glycolate. Diversity and dynamics of glycolate-utilizing bacteria were characterized in six lakes using functional gene glycolate oxidase subunit D (glcD). Freshwater glycolate-utilizing populations exhibited a range of taxonomic diversity and …
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Total Syntheses of (+)-Geldanamycin, (-)-Ragaglitazar, and (+)-Kurasoin A and Phase-Transfer-Catalyzed Asymmetric Alkylation
… of GA and future synthetic analogs. Asymmetric glycolate alkylation has been developed using phase-transfer-catalysis (PTC). Diphenylmethoxy-2,5-dimethoxyacetophenone with trifluorobenzyl cinchonidinium catalyst and cesium hydroxide provided alkylation products at —35 °C in high yield (80-99%) …
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Defining the role of 4-hydroxy-2-oxoglutarate aldolase in hydroxyproline metabolism and primary hyperoxaluria
… and dietary sources, leads to an increase in glycolate and oxalate levels in plasma and urine. Furthermore, it has been shown that Hyp metabolism is likely the major contributor to the glyoxylate pool which can then go on to form oxalate in PH patients. Therefore, inhibition of Hyp degradation …
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Studies of the effects of various lithogenic and antilithogenic dietry supplements on calcium oxalate kidney stone risk factors in South African black and white subjects
… taurine, which has been shown to reduce urinary glycolate and oxalate in animal models, was also selected for investigation in the two population groups. In all studies, similar protocols were adopted. These were approved by the Research and Ethics Committee of the University of Cape Town.
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Palladium-Imidazolium Carbene Catalyzed Heck Coupling Reactions and Synthesis of a Novel Class of Fluoroanthracenylmethyl PTC Catalysts
… were synthesized and explored for asymmetric glycolate and glycine alkylation. Phosphorous pentoxide was used for the challenging electron-deficient electrophilic aromatic substitution step. These new catalysts proved to have high selectivities for glycine alkylation under mild conditions.</p>
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Exploring co-milling as a strategy to improve the dissolution of poorly water-soluble drugs
… excipients: croscarmellose sodium, sodium starch glycolate, and crospovidone. All 39 co-milled formulations showed increased intrinsic dissolution rates (IDR), with molecular descriptors such as polar surface area and size correlating positively with enhancement. Excipient performance varied with …
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Synthesis, study and application of silyl ketene imines in Lewis base catalyzed carbonyl addition
… allow for the preparation of cross-benzoin and glycolate-aldol products in high yield and with exceptional diastereo- and enantioselectivities.
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Genome-scale metabolic modelling of Salmonella and Lactobacillus species
… that interactions, involving the transfer of glycolate from L. plantarum to S. Typhimurium, that favour growth of S. Typhimurium, are possible, by unlikely to occur in vivo. Data from Phenotype Microarray (PM), as well as DNA microarray data obtained during infection of cultured macrophage …
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Genome scale metabolic modelling of Phaeodactylum tricornutum
… pathway, threonine metabolism, recycling of glycolate and HCO3 fixation. Based on the model analysis, experiments were designed where cultures were exposed to high light, supplemented with HCO3 , under phototrophic and mixotrophic conditions. This resulted to an increase in biomass and lipid …
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On the Effectiveness and Challenges of Electrosynthesis Strategies in Escherichia coli
… glucose as a feedstock was examined. The maximum glycolate titres for the best performing conditions reached 10.6 g/L. The highest substrate uptake rate for ethylene glycol was determined to be ca. 5 mmol/gDW-h.
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Microbial synthesis of 3,4-dihydroxybutyric acid, 3-hydroxybutyrolactone and other 3-hydroxyalkanoic acids
… glyoxylate shunt and independent control of the glycolate and 3HA pathway enzyme expression using two orthogonal expression systems was critical for product synthesis. Additionally, a study of the 3HBL/DHBA fermentation at the shake flask and bench-top bioreactor scales helped gain an …
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Evaluation of oxidative enzymes in leaf tissue from intact cotton plants exposed to different oxygen concentrations
… analyzed, catalase activity decreased 30%, glycolate oxidase activity decreased 42%, and peroxidase. increased 89% while soluble protein decreased 27% in plants maintained in the high humidity for 5 days. Exposure of plants to 75% oxygen, 350 ppm carbon dioxide for 48 hr under these …
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Studies Towards the Total Synthesis of Patellazole B
… C13-C19 fragment is outlined. A boron-mediated glycolate aldol has been used to install the C16-C17 anti stereochemistry and a substrate-controlled reduction at C15 delivered the hydroxyl with high diastereoselectivity. Studies into the C¬17¬ methylation are also described. Chapter 4 describes …
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Role of Hydroxy acid oxidase 2 (Hao2) in hepatocellular carcinoma
… a broad range of 2-hydroxy acids, ranging from glycolate to long chain 2-hydroxy fatty acids, such as 2-hydroxypalmitate, to 2-keto acids; this reaction results in hydrogen peroxide (H2O2) formation at the expense of molecular oxygen. Aim: Since no data concerning Hao2, a member of this family, …
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Investigating the effect of phytoplankton on bacterial community composition across different environmental contexts
… potential for bacteria to use the algal exudate glycolate, was characterized in Emerald Lake, an oligotrophic high-elevation lake that shifts from primarily terrestrial-derived organic matter following ice-off to primarily phytoplankton-derived organic matter. glcD genes were not detected in …
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A study of Door Pulls on Isolation Carts in a General Hospital for Evidence of Contamination
… innoculated on blood agar plates and in thio- glycolate broth. These were incubated at 37.5° Centigrade for seventy-two hours. Plates were examined daily for any bacterial growth. Any growth seen was restreaked on new blood agar plates. Smears were made on colonies on all plates that showed any …
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