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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"glycogen synthesis"”.
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Influence of carbohydrate feeding during exercise on muscle glycogen synthesis after exercise
There is no abstract available for this dissertation.
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Insulin-like growth factor-1 stimulates glycogen synthesis in the bovine uterine epithelium
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-15 without embargo terms
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Aspects of hormonal regulation of hepatic carbohydrate and lipid metabolism
… for conversion of dietary carbohydrate<br/>into glycogen and triglyceride. Hepatic rates of fatty acid and<br/>glycogen synthesis were measured y vivo in response to meal-feeding<br/>(2h/day) by the incorporation of from 3H20. This technique has not<br/>been applied previously to glycogen …
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The Effects of Low Dose Endotoxin on Glucose Homeostasis
… treatments would enhance insulin-signaling and glycogen synthesis while long-term treatments would have inhibitory effects. Under our second hypothesis, we examined whether short-term low-dose treatments of endotoxin would contribute to improvements in glucose tolerance in a mouse model. In …
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The Impact of Candida albicans Glycogen on Fitness, Virulence and Host Response
… Although largely unexplored in C. albicans, the glycogen metabolism pathway is a vital carbon assimilation and utilization system shown to be metabolically important in the model yeast Saccharomyces cerevisiae. Aside from the soluble glycogen that potentially contributes to Candida metabolism, …
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The role of glycogen Metabolism in the Adaptation to environmental Changes of the cyanobacterium Synechocystis sp. PCC 6803
Glycogen is the primary polysaccharide in cyanobacteria, serving as a critical carbon and energy reservoir to support cellular energy homeostasis. Its metabolism is conserved, requiring only a few steps from glucose-6P to incorporate glucose molecules into glycogen chains. This study investigates …
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Muscle glycogenolysis during weight-resistance exercise
Skeletal muscle glycogenolysis was investigated in eight subjects during both high (HI) (70% 1 RM) and low (LO) intensity (35% 1 RM) leg extension weight-resistance exercise. Total force application to the machine lever arm was determined and equated between trials via a strain gauge and computer …
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The effect of oral-hypoglycaemic drugs and obesity on insulin receptor binding
… litter mates. The rate of insulin stimulated glycogen synthesis was reduced in the obese mouse between 5 and 40 weeks of age. This defect preceeded the appearance of reduced insulin receptor binding at 10 weeks and a defect beyond the insulin receptor is therefore proposed as a primary …
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Insulin Signaling & Glucose Metabolism in Glycolytic & Oxidative Muscle of High Fat Fed & Endurance Trained
… (IS) cascade, leading to blunted rates of glycogen synthesis (GSR) and reduced glucose-6-phosphate (G6P) content in all muscles fiber types (MFTs) of HF-fed rodents. Conversely, CEE increased insulin sensitivity, increased GSR and G6P content. Our work has shown that hyperlipidemia causes …
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Small molecule kaempferol, a novel regulator of glucose homeostasis in diabetes
… high fatty acid-impaired glucose uptake and glycogen synthesis in SkM cells, which were associated with improved AMPKα activity and Glut4 expression. In addition, dietary kaempferol treatment preserved functional pancreatic 𝜷-cell mass and prevented hyperglycemia and glucose intolerance in …
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Effects of resveratrol and contractile activity in human skeletal muscle myotubes from severely obese individuals
… (1 [micro]M) improved insulin-stimulated glycogen synthesis, an index of insulin sensitivity in cell culture, as well as glucose oxidation in the myotubes of severely obese individuals despite suppressed responses compared to lean counterparts. The molecular mechanism involved appeared to …
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The Role of Angiotensin II in Skeletal Muscle Metabolism
… investigated. Fatty acid oxidation and lipid synthesis was measured using [1-14C]-palmitate, glucose oxidation and glycogen synthesis were measured using 14C-glucose. In addition,mitochondrial oxidative capacity was measured using an XF 24 Flux Analyzer (Seahorse Bioscience) and reactive …
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The Novel Role of Interleukin-1 Receptor-Associated Kinase 1 in the Signaling Process Controlling Innate Immunity and Inflammation
… is involved with the negative regulation of glycogen synthesis through inhibiting PI3K-Akt signaling pathway and thus releasing GSK3β's inhibitory effect on glycogen synthase. Moreover, our studies also suggest that IRAK-1 is involved in the activation of transcription factors CREB and ATF-1 …
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Urinary ascorbic acid excretion and sugar consumption as indices of enzyme induction and hypoglycemia in recovering alcoholic rats
… urinary excretion of ascorbic acid may suppress glycogen synthesis, leading to hypoglycemia.
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The effects of herbal extracts and compounds on the glucose metabolism in Hep G2 cells
… of glucose transporter-1, and the assessment of glycogen content, glucose release, and Seahorse metabolic analysis. In studies on glucose uptake using flowcytometry, metformin increases 1.8-fold, goldenseal stimulates 2-fold, and berberine augments 3.4-fold more glucose uptake than the control …
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Plasma Extracellular Vessicles, Exercise Resistnace and Cancer
… of diverse signaling pathways, including glycogen synthesis, myogenesis and AMPK signaling in obese individuals. Finally, we utilized the biomarker potential of SEC-MS to identify differences in protein abundance and composition in EVs isolated from individuals with the hematological …
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Hypoglycemia-induced changes in glucose metabolism in the hypothalamus
… concentrations, but we observed altered glycogen metabolism through changes in expression of genes involved in glycogen synthesis and mobilization. Impact of altered brain glycogen metabolism in the development of HAAF is underway, but research to gain a robust understanding brain …
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Purification of protein phosphatases and 14-3-3-binding proteins and their regulation by the cAMP–PKA pathway
… in various cellular processes including glycogen metabolism, cell cycle control, RNA splicing, DNA synthesis, muscle contraction and mitosis. Protein kinases and phosphatases regulate the phosphorylation status of proteins in response to intra and extracellular stimuli such as hormones …
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Multimethodological approaches to tackle glycogen: therapeutic and modelling opportunities in Lafora disease
… universally prevail. Indeed, some neurological glycogen storage disorders manifest through the accumulation of aberrant glycogen into polyglucosan bodies (PGBs). These include Lafora disease (LD), a lethal myoclonus epilepsy, caused by loss-of-function mutations in either EPM2A or NHLRC1 genes …
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Investigating Invadolysin's activity: discerning mechanism and cellular roles
… lines. During my PhD, my aim was to study the biosynthesis, activity and function of invadolysin and investigate its role in metabolism and adipogenesis. Invadolysin has a conserved metalloprotease motif ‘HEXXH’ and a potential lipase motif ‘GXSXS’. One of the aims of my PhD was to generate mutant …
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