Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"glycogen synthase kinase 3 beta"”.
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A Role for Glycogen Synthase Kinase 3 beta in the Regulation of Glucagon Gene Transcription by Insulin
… 2040-2305 enthielt. Dies konnte durch in vitro Kinase assays gezeigt werden. Die Ergebnisse zeigen, das GSK3-b in die Regulation des Glucagongens involviert ist.
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Connecting brain tumor stem cells with their primary tumor and exploring glycogen synthase kinase -3ß regulation of cell fate
… molecule screen targeting GSCs, we identified glycogen synthase kinase 3-beta (GSK3ß) inhibitors as likely candidates. We observed that pharmacological and genetic knockdown of GSK3 induced apoptosis and differentiation, preferentially in the CD133-expressing tumor-initiating fraction. In …
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Gsk3Beta-Mediated Ezh2 Phosphorylation Suppresses Methylation of H3K27 and Ezh2’S Oncogenic Functions
… regulation of EZH2 activity by tumor suppressor kinase is not well understood. Glycogen synthase kinase 3 beta (GSK3b), a multifunctional serine/threonine kinase, is involved in many cellular processes. GSK3b also participates in neoplastic transformation, tumor development and regulate cancer …
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Blood and Lumbar Fluid Biomarker Changes in Patients with HIV-Associated Neurocognitive Impairment Treated with Lithium: Analysis from a Randomised Placebo-Controlled Trial
… factors (BDNF). Lithium is also an inhibitor of glycogen synthase kinase-3 beta (GSK-3-β). We analyzed biomarkers obtained from participants in a randomized placebo-controlled trial of lithium in ART-treated individuals with moderate or severe HAND. We assayed markers at baseline and 24 weeks …
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Roles of GSK-3beta and PYK2 signaling pathways in synaptic plasticity
… examines the role of two signaling pathways, glycogen synthase kinase 3 beta (GSK- 3beta) and proline-rich tyrosine kinase 2 (PYK2), in LTD at rat hippocampal synapses. GSK-3beta, a serine/threonine kinase implicated in the pathophysiology of schizophrenia, mood disorders, and Alzheimer's …
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Towards the establishment of a highly effective adeno-associated virus production by leveraging next generation sequencing and transcriptomics in HEK293 cells
… upon knockdown. Partial depletion of catenin beta 1, ubiquitin conjugating enzyme E2 G2, and glycogen synthase kinase 3 beta transcripts showed positive trends in terms of cell health and viral productivity, warranting further research. In light of significant changes in chromatin structure …
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Use it and boost it: cognitive and physical activities modulate cognition via BDNF-TrkB signaling
Our motto “Use it and boost it” suggests that stimulating experiences enhance neural functioning. Previous work has shown that cognition is enhanced by mental and physical activities. The current research examines the molecular mechanisms underlying cognitive and physical activity-induced …
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Effects of alcohol and ∆9-tetrahydrocannabinol on energy balance and cognitive behaviors
… changes in CB1R protein expression and basal glycogen synthase kinase-3 beta (GSK-3β) activity in the medial prefrontal cortex (mPFC; center for executive function control), mediobasal hypothalamus (MBH; energy balance regulator), and hippocampus (HIP; involved in spatial learning) during drug …
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Treatment of HIV associated neurocognitive disorders
… effect of lithium, including the inhibition of glycogen synthase kinase-3- beta, which mediates inflammation signaling pathways and neuronal apoptosis. Lithium has been used in mood disorders and other neuropsychiatric conditions for more than 40 years. In addition, lithium is a low-cost drug …
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The effects of prenatal and early-postnatal ethanol exposure on rat brain neurochemistry and behaviour
… reference to the extracellular signal-regulated kinase1/2 (ERK1/2) and glycogen synthase kinase-3-beta (GSK3β) signalling cascades, using two different animal models of FASD. Further, to elucidate additional mechanisms underlying the deficits observed in FASD, proteomic profiles were determined …