Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"glycogen synthase kinase (GSK)"”.
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Functional role of GSK3β in p38MAPK mediated human amnion membrane senescence
… stress signaler p38 mitogen-activated protein kinase (p38MAPK) activation and fetal membrane senescence are associated with parturition. Our study determined changes in multipotent pro-cell cycle regulator glycogen synthase kinase (GSK) 3β and its regulation by p38MAPK in effecting senescence …
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CELLULAR AND MOLECULAR MECHANISMS OF AT2R MEDIATED ANTI-PROTEINURIC ACTIVITY
… are indications suggesting the involvement of glycogen synthase kinase (GSK)-3β-mediated megalin phosphorylation, and its subsequent endocytosis and lysosomal degradation resulting in proteinuric kidney injury. Present study reports that acute treatment with angiotensin-II type 2 receptor …
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Analysis of Immunomodulatory Effects of Vitamin D in Epithelial-Mesenchymal Transition and Airway Remodeling in Allergic Airway Inflammation.
… VDR expression, and increased phosphorylated glycogen synthase kinase (GSK)-3β. The effect of vitamin D on VDR and pGSK-3β was also analyzed in human bronchial epithelial cells treated with TGF-β1 or TGF-β2. Inflammatory conditions used to mimic EMT resulted in the decreased expression of VDR …
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Natural Products Chemistry of Leads Acting on MRSA, HCV, Malaria, and Depression Disorders
… cytotoxicity, and also their potential for glycogen synthase kinase (GSK-3β) inhibition using molecular docking studies. Among the analogs, 2-N-methylmanzamine A exhibited antimalarial activity (IC50 0.7 – 1.0 µM), but was less potent than manzamine A. However, the compound was significantly …
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Wnt Signaling in Growth Cone Mediated Neurite Outgrowth from Spiral Ganglion Neurons in the Adult Mouse
Profound sensorineural hearing loss affects nearly 700,000 people in the United States and cannot be treated with hearing aids. Many listeners receive cochlear implants that can restore hearing by directly stimulating spiral ganglion neurons with electrodes implanted in the inner ear. However, the …