Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"glycoengineering"”.
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Engineered Oligosaccharyltransferases With Unique N-Glycosylation Site Preferences
… oligosaccharyltransferase (OST) in bacterial glycoengineering area. While C. jejuni PglB performs well in transferring different glycans, the acceptor sites it can recognize are limited. We provided a thorough investigation into Desulfovibrio desulfuricans PglB (DdPglB), an OST sharing …
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Investigating the size effect of nanoparticles in Click Chemistry mediated cancer targeting
… NPs onto the cell surface via metabolic glycoengineering for the cell surface placement of azido group followed by Click Chemistry mediated covalent reaction between the NP and the cell, we demonstrate that the combination effect of deeper penetration of smaller-size NP coupled with …
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Biochemical characterization of Cj 1123 c, a putative acetyltransferase & Cj 1319, a putative C6 dehydratase from Campylobacter jejuni.
… sugar biosynthesis, they could be applied as glycoengineering tools.
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Controlled metabolic cell labeling and bioorthogonal click chemistry for cancer targeting
… Click chemistry. By controlling the metabolic glycoengineering processes of unnatural sugars via rational chemistry designs, I was able to design a library of trigger-activatable sugar precursors that can label cell surface with chemical groups (e.g., azides) only in the presence of either …
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Emerging out of the “blur”: exploration, evaluation and significance of 3D N-glycans’ structure through molecular dynamic studies
… of complex N-glycans, with applications in glycoengineering and therapeutic and diagnostic strategies.
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New Carbohydrate-Based Anti-Cancer And Anti-Bacterial Vaccines
… a novel immunotherapeutic strategy based on glycoengineering of sialo-TACAs on cancer cells. An important requirement for this strategy to work is to engineer cancer cells to express unnatural sialo-TACAs. In Chapter 2, a convenient method was developed for the quantification of various …