Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"glycocalyx"”.
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Modelling the Endothelial Glycocalyx Layer
… flow in microvessels coated with an endothelial glycocalyx layer (EGL). Special attention is focused on the effect of the wall layer on the system as a whole and the interaction between blood, EGL and the wall vessel. Interest in this problem is motivated by its implications for better …
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Developing Constitutive Laws for the Endothelial Glycocalyx Layer
… new mathematical models for the Endothelial Glycocalyx Layer (EGL) in order to improve our understanding of the layer and its functions, particularly in the microcirculation. The EGL is a porous macromolecular layer that lines the insides of blood vessels. It is located on the important …
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Glycocalyx acting as a mechanotransducer of fluid shear stress
… thick endothelial surface layer, also called the glycocalyx, with an estimated thickness on the scale of 0.5 pm, which restricts the flow of plasma and can exclude red blood cells and some macromolecular solutes. Based on our current understanding of signal transduction, we expect that the …
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The Role of the Stereociliary Glycocalyx in Hair Bundle Cohesion
… I demonstrated that the stereociliary glycocalyx acts as a negatively charged polymer brush, necessary for the soundness of the glyco-tethering hypothesis. I found by force-fiber photomicrometry that when the distal tips of stereocilia were brought together they formed elastic …
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Effect of Diabetes Mellitus on Ocular Surface Tight Junctions and Glycocalyx
… eye disease. Impairment of tight junctions and glycocalyx, which are critical for ocular surface barrier function, may underlie these diabetes-associated ocular surface defects. Therefore, the present study was designed to investigate the effect of high glucose exposure and type I diabetes …
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Three-dimensional flow-induced dynamics of the endothelial surface glycocalyx layer
… presence of a delicate surface layer, named the glycocalyx, decorating the endothelial membrane and associated with a number of physiological implications in the vasculature. This thesis studies the flow-induced dynamics of the endothelial glycocalyx layer and reports the first direct measurement …
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The Biophysical Role of the Cellular Glycocalyx: Engineering Glycoproteins to Control Cell-Surface Properties
The glycocalyx is the sugary coating on the surface of essentially all mammalian cells. Despite being a major class of biomolecules, research into carbohydrates has lagged behind other classes of biomolecules such as nucleic acids and proteins. The constituent parts of the glycocalyx are not …
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HOW MICROVESICLES ARE "BUDDING" INTO THE CANCER CONVERSATION: THE ROLE OF GLYCOCALYX-INDUCED MEMBRANE BENDING
… encoded toolbox of synthetic to native glycocalyx biopolymers to understand the role of the glycocalyx in membrane bending and microvesicle biogenesis. We demonstrate that molecular crowding on the plasma membrane by flexible glycocalyx biopolymers allows membrane bending to occur. …
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Generation and Characterization of Human Blood-Brain Barrier Models for Investigating Neuropsychiatric Disorders and Tumor Metastasis
… tight junction proteins and the endothelial glycocalyx that determine the integrity of the BBB are significantly disrupted. It was also found that CRKL, a gene within the 22q11.2 DS deletion region, contributes to the deficit. The CRKL is a major substrate of the Abl tyrosine kinase, and the …
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The role of the arterial glycocalyx in sphingosine-1- phosphate induced cardioprotection in the isolated heart of the Wistar rat
… coronary vascular structures, the endothelial glycocalyx is a delicate polysaccharide and protein-rich layer that plays an important role in the regulation of vascular permeability, and is easily damaged during I/R. Sphingosine-1-phosphate (S1P) is a membrane phospholipid metabolite that has …
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Modulation of Brain Tissue Transport and Endothelial Glycocalyx and Tight Junctions of the Blood-Brain Barrier by Transcranial Direct Current Stimulation
… is to temporarily disrupt the endothelial glycocalyx (EG) and tight junctions of the BBB. The second part of the dissertation aimed to confirm this prediction indirectly in vivo by quantifying the BBB permeability to solutes with the same size but carrying opposite charges under control and …
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The Role of Surface Properties in the Transport of Folates Across the Intestine
The importance of the intestinal epithelial cell glycocalyx in the transport of folates in the intestine has been demonstrated. It was proposed that the glycocalyx acts as a retaining layer for the acid microclimate on the jejunal mucosal surface. Histological investigation of human jejunal …
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Mathematical models for interendothelial cleft
… is to examine the charge effects of surface glycocalyx on microvessel permeability; To investigate the microstructural mechanisms of decreasing microvascular permeability induced by the enhancement of intraendothelial adenosine 3 ',5'-cyclic monophosphate (CAMP) levels, we extended the …
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Circulating proteoglycans and glycosaminoglycans during critical illness
The endothelial glycocalyx is the carbohydrate rich inner layer of the blood vessels. Important components of the glycocalyx are the proteoglycans with their attached glycosaminoglycans. At this location these molecules contribute to the adhesion and transport of leucocytes to inflamed tissue, the …
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Characterization of Ocular Surface Pathology and Tear Film Dysfunction Due to Type 1 and Type 2 Diabetes Mellitus
… components like tear film, goblet cells and glycocalyx, has not yet been investigated. These pathological changes can potentially cause dry eye and corneal injury including epithelial erosion, impaired wound healing and keratopathy. As the mainstay treatment option for the management of dry …
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Investigating the integrity of the vasculature and structural relationships of pericytes, astrocytes and the endothelial glycocalyx in an ex vivo hyperglycaemic rat retinal model
… dysfunction as well as the thinning of the glycocalyx in the retinal vasculature of diabetics. As such, the underlying mechanism of how hyperglycaemia induces retinal damage is not fully understood, particularly at the early stages of the disease. Aim and Objectives: To establish and …
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Systems biology of endothelial mechano-activated pathways
… the expression of components of the endothelial glycocalyx, a mechanosensor that regulates shear-stressdependent NO production. Nitric oxide produced by vascular endothelial cells is an anti-inflammatory mediator and a potent vasodilator. In order to understand the rich diversity of responses …
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Colloidal semiconductor nanocrystals as nanoscale emissive probes in light emitting diodes and cell biology
… 5 applies the method to measure the endothelial glycocalyx thickness in vitro for the first time, by labeling different proteins with NCs of different emission wavelengths. Taking a step further, Chapter 6 utilizes the NC based imaging method to investigate the flow induced dynamics of …
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Mechanisms of Metastatic Spread of Breast Cancer to the Brain
… is the cerebral endothelial surface layer or “glycocalyx” that covers the luminal surface of all blood vessels. Glycocalyx disruption has been reported in tumour progression, but it is not fully understood how circulating TNBC cells interact with, and alter, the cerebral capillary glycocalyx …
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Effects of a superovulatory dose of pregnant mare’s serum gonadotropin on uterine morphology, carbohydrate histochemistry and serum steroids in immature rates
… and the carbohydrate composition of the uterine glycocalyx and secretions in immature rats and in untreated mature rats. The morphological and carbohydrate histochemical changes found were correlated to the serum concentrations of estradiol, progesterone and androgens. Female 28 day old …
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