Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"glycine receptor"”.
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Direct Inputs to off Α and G9 Ganglion Cells From Aii Amacrine Cells In Rabbit Retina
… labeled with an antibody against calretinin and glycine receptors were marked with an antibody against the α1 subunit. This material was analyzed by triple-label confocal microscopy. We found the lobules of AIIs made close contacts at many points along the dendrites of individual OFF α and G9 …
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Nova Regulation of Alternative Splicing in the CNS
… Nova-dependent splicing regulation, exon 3A of glycine receptor α2 subunit (GlyRα2), two new targets are identified, which are the alternative exon, E9 in the inhibitory neurotransmitter receptor subunit, GABAARγ2, and the alternatively spliced exon H in Nova-1's own message. Nova acts to …
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Functional Roles of Nova in RNA Metabolism
… a sequence of RNA found in an intron of the glycine receptor a2 subunit pre-mRNA. Evidence that Nova-1 acts as a regulator of alternative splicing in transfected cell lines is presented. Furthermore, a direct role of Nova-1 on splicing is demonstrated by establishing an in vitro assay for …
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The Paraneoplastic Antigen Nova-1 is a Neuron Specific and Sequence Specific RNA Binding Protein
… alternatively spliced exons (3A and 3B) of the Glycine receptor α2A (glyRα2A), and downstream of the alternatively spliced exon H of Nova-1, and demonstrate that Nova-1 binds these RNAs with high affinity (Kd ~2 nM). We have also shown that Nova-1 binds both the glyRα2A and Nova-1 pre-mRNAs in …
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Interactions between Nova and brPTB Proteins in Alternative Splicing and Nuclear Localization
… spliced exons in two target pre-mRNAs: glycine receptor oc2 subunit (GlyRa2) and GABAA receptor y2 subunit (GABAARy2). Furthermore, in the case of GlyRoc2, brPTB binds to a site adjacent to Noval in a 90 nucleotide fragment of intronic RNA upstream of the alternatively spliced exon, but …
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Analysis of ion channel stochastic signals for biosensing
… ion channel: the homomeric α2 isoform of the glycine receptor. It involved both experimental acquisitions and signal analysis. The last chapter represents the conclusions of this thesis, with some remark on the effective performance that may be achieved using ligand gated ion channels as …
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Tranexamic Acid Modulation of Excitatory and Inhibitory Amino Acid Receptors: A Potential Mechanism for Postoperative Seizures
… enhancing the function of excitatory amino acid receptors (NMDA, AMPA, and kainate receptors). Alternatively, TXA could cause disinhibition by reducing the activity of inhibitory receptors (GABA and glycine receptors). The purpose of this thesis is to identify molecular targets that are sensitive …
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Spinothalamic tract neurons in laminae I, III and IV of the rat: a retrograde neuronal tracing study
… of puncta that were immunoreactive for the glycine receptor-associated protein, gephyrin, and have a very high density of input from glutamatergic axons that contain vesicular glutamate transporter 2 (VGLUT2). These "large gephyrin-coated cells" in the lumbar cord are known to project to the …
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PLASTIC CHANGES IN THE INHIBITORY GLYCINE SYSTEM OF THE DORSAL COCHLEAR NUCLEUS (DCN) IN A RAT MODEL OF TINNITUS
… and protein levels of &alpha<sub>1-3</sub> glycine receptor subunits (GlyRs), gephyrin, BDNF and its receptor TrkB were assessed in dorsal cochlear nucleus (DCN) fusiform cells 4 months post exposure utilizing quantitative in situ hybridization and immunocytochemistry. Young exposed rats …
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The Developmental and Behavioral Effects of Δ9-Tetrahydrocannabinol on a Spastic Mutant
… where the <em>glrbb</em>mutation results in glycine receptor (GLYR) loss of function glycine receptors and ultimately, improper inhibitory signaling. Though hyperekplexia is a glycinergic-based signaling disorder, disease symptoms are often alleviated with GABA-agonistic benzodiazepines. …
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Computational modeling and simulation of ligand-gated ion channels
… a century. The muscle nicotinic acetylcholine receptor (nAChR), a member of the pLGIC superfamily, was the first ion channel to be extracted and thus became a model system not only for pLGICs but for all ligand-gated ion channels. Thanks to decades of electrophysiology experiments along with …
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Developing Antibody Tools against Glycine Receptors
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Computational modelling of the glycinergic synapse
Glycine is the simplest and smallest amino acid present in human proteins. It has many important roles in human as an intermediate of biosynthetic one carbon metabolism pathways, component of structural proteins, and in the brain acting as the second major inhibitory neurotransmitter via the …
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Molecular determinants of conductance and charge-selectivity in pentameric ligand-gated ion channels
… (in vertebrates) the nicotinic Acetylcholine Receptor (AChR), Serotonin Receptor type 3 (5-HT3R), γ-Aminobutyric acid Receptor type A (GABAAR), and the Glycine Receptor (GlyR). All of these channels are made up of five subunits. Some pLGICs are homomeric and others are heteromeric. For …