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Showing 1 to 12 of 12 for “"glycerophospholipid"”.
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NMR characterization of chlorhexidine in lipid-based formulations /
A mixture of Chlorhexidine digluconate (CHG) with glycerophospholipid 1,2-dimyristoyl- <^54-glycero-3-phospocholine (DMPC-rf54) was analysed using ^H nuclear magnetic resonance. To analyze powder spectra, the de-Pake-ing technique was used. The method is able to extract simultaneously both the …
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Multi-omic Approaches to Investigate the Inflammatory Response in Activated Macrophage Cells
… regulation of arachidonic acid and glycerophospholipid metabolism.<br/>Furthermore, a novel stable isotope labelling methodology was developed using<br/>deuterium oxide (2H2O) in conjunction with high resolution mass spectrometry for the simultaneous measurement of the rates of …
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Molecular characterization of the lipidome by mass spectrometry
… characterization and quantification of molecular glycerophospholipid species, molecular diacylglycerol species, molecular sphingolipid species including ceramides, glycosphingolipids and inositol-containing sphingolipids, and sterol lipids including cholesterol. The performance of the methodology …
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Regulation of The Expression and Lysine Acetylation of Pro-Inflammatory Molecules By Lipid-Modifying Enzyme (LPCAT2) in RAW264.7 Cells
… that significantly regulate changes in the glycerophospholipid components of the macrophage membrane phospholipid bilayer. LPCAT2 is a subtype of LPCAT that regulates inflammatory responses to infection by lipopolysaccharides and lipopeptides. LPCAT2 co-localises with TLR4 and prevents its …
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Novel lipid regulation of vacuolar fusion in saccharomyces cerevisiae
… the fusion pathway, vacuoles accumulate the glycerophospholipid phosphatidylinositol 3-phosphate (PI3P). PI3P is a positive regulatory of fusion that functions through the recruitment of multiple components of the vacuolar fusion machinery including the soluble SNARE Vam7. Vam7 interacts with …
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Microbial, metabolic and molecular determinants of neonatal mortality in the rural areas of Limpopo Province, South Africa: umblical cord blood metabolomic profile and bacterial anaysis and their association with perinatal complications
… lipid metabolism, sphingolipid metabolism, and glycerophospholipid metabolism, were identified as statistically significant. CONCLUSION: Our study revealed a high occurrence rate of perinatal complications (25.58%), with maternal high blood pressure, maternal age (10-19 years), low birth weight, …
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Exploring the Plasmodium falciparum Transcriptome Using Hypergeometric Analysis of Time Series (HATS)
… increase in pfmdr1 resulted in increases in glycerophospholipid metabolism and up-regulation of a number of ABC transporters. Finally, when comparing artemisinin sensitive to artemisinin tolerant lines, we found an increased abundance of redox metabolites and the transcripts involved in redox …
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Stage-Specific Multiomic Analysis of Human Erythroid Differentiation
… lipidomic analyses uncovered changes in glycerophospholipid (GPL) and lysophospholipid species, consistent with differential expression of GPL metabolism genes observed in the scRNA-seq dataset. These included MBOAT2, LPCAT3, CHPT1, and PEMT, whose Epo-mediated changes were validated at …
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Genomic and metabolomic interrogation of body composition and insulin resistance endotypes
… remodelling, mitochondrial fatty-acid handling, glycerophospholipid metabolism, and amino-acid utilisation/acetylation in LD relative to primary insulin signalling defects, including perturbations in BCAA flux and tryptophan–kynurenine/indole metabolism. The studies in this thesis use …
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Contribution of different types of phospholipids in blood coagulation
… support fX activation. We showed that almost any glycerophospholipid other than phosphatidylcholine (PC) synergizes strongly with PS to enhance factor X activation by factor VIIa/tissue factor. We proposed that PC and sphingomyelin (the major external phospholipids of healthy cells) provide an …
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Characterization of Molecular Glycerophospholipids by Quadrupole Time-of-Flight Mass Spectrometry
The physical properties of glycerophospholipids (GPLs) are not only determined by the head group (HG), but also by their fatty acid (FA) chains, which affect their distribution and function within membranes in the cell. Understanding the microheterogenity of lipid membranes on a molecular level …
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The Interaction of Obesity and Age and their effect on Adipose Tissue Metabolism in the Mouse
… composition of cell membranes, and in particular glycerophospholipids, an important membrane component, have been seldom investigated. Cell membrane components contribute to a variety of cellular processes including maintaining organelle functionality, providing an optimized environment for …