Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"glutathione-S-transferase"”.
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Identification and Characterization of A Zebrafish Glutathione S-Transferase Pi
Glutathione S-transferases (GSTs) are a major group of Phase II enzymes involved in the detoxification of certain endogenous compounds such as reactive oxygen species (ROS) generated during metabolism, as well as in the detoxification of xenobiotics including drugs. In recent years, the zebrafish …
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Catalytic and non-catalytic mechanisms involved in Glutathione S-transferase Pi mediated cytoprotection
Glutathione S-transferases (GSTs) are a multi-gene family of enzymes involved in the detoxification of a wide range of electrophilic compounds and are an integral component to antioxidant defence in the mammalian cell. Among GST, the Pi class (GSTP1) is the most prominent extrahepatic isoform in …
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The identification, purification and characterization of the fetal rat liver glutathione S-transferase isoenzyme YcYfetus
This study has examined the expression of the glutathione S-transferases (GSH S-T) in fetal rat livers in order to provide more information about the role played by this important group of enzymes in the fetus. The study commenced with an examination of the subunit composition of adult and fetal …
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Repurposing BT-11 to Treat Alzheimer’s Disease: Exploring the Glutathione-s-transferase LANCL2 as a Target
… Additionally, LANCL2 was identified as a glutathione-s-transferase, suggesting a role in removing toxins and reducing oxidative stress. BT-11 was predicted to have potential to treat Alzheimer’s, based on <em>in silico</em> studies for drug repurposing.</p> <p>The overall …
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An Investigation Into the Synergistic Interaction of Tridiphane and Atrazine (Cyanazine, Giant Foxtail, Glutathione-S-Transferase)
Restricted to the U of I community indefinitely during batch ingest of legacy ETDs
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The Glutathione S-Transferase GliG Mediates Gliotoxin Biosynthesis, not Self-Protection, in Aspergillus fumigatus: A Functional Genomic Investigation.
… gliG, herein shown to be an epoxide-conjugating glutathione stransferase, from the gli cluster results in loss of gliG expression and the complete abrogation of gliotoxin biosynthesis. Instead, this deletion mutant, A. fumigatus !gliG, secretes a 6-benzyl-6-hydroxy-1-methoxy-3- …
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An investigation into the association between cytochrome P450 and glutathione S-transferase detoxification enzyme polymorphisms and human oral squamous cell carcinoma
… between polymorphisms in cytochrome P450 and glutathione S-transferase genes and disease susceptibility in 106 patients with histologically proven squamous cell carcinoma of the oral cavity. The CYP2D6 PM phenotype was associated with a significantly increased risk of oral cancer (p = 0.0012). …
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Factors influencing arbovirus transmission: vector competence and the effects of virus infection on repellent response, oxidative stress, and glutathione-S-transferase activity
… ZIKV and LACV infection on oxidative stress and glutathione-S-transferase (GST) activity in Aedes albopictus. Virus infection had no effect on oxidative stress, but GST activity was significantly different for mosquitoes 3-days post-exposure. We found that oxidative stress levels and GST activity …
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Influence of molecular and genetic factors of the organism΄s antioxidative system on cervical carcinogenesis and the role of these factors in treatment of locally advanced cervical cancer /
… - to assess the importance of molecular (reduced glutathione (GSH) and glutathione S-transferase (GST)) and genetic (glutathione S-transferase (GST) genes polymorphism) factors determining the activity of antioxidative system for development of cervical cancer and evaluate the role of these …
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Breast Cancer Inhibition by Grape Constituents
… activity of the phase II metabolizing enzyme, glutathione S-transferase. Based on in vivo research, we evaluated grape color extract (GCE) and two select anthocyanins for their capacity to inhibit benzo[a]pyrene (BP)-induced DNA adduct formation in MCF-10F cells. GCE and each anthocyanins …
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QUANTITATIVE DETECTION OF LIVER-RELEVANT BIOMARKERS BY SERS-IMMUNOLABALED GOLD NANOPARTICLES
… device. Human Serum Albumin (HSA) and α-Glutathione S-Transferase (α-GST) are liver biomarkers that indicate liver health and damage respectively. Herein we demonstrate
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rd1 Photoreceptor Degeneration: Photoreceptor Rescue and Role of Metalloproteases in Retinal Degeneration
… Lens Epithelium Derived Growth Factor (LEDGF), Glutathione S-Transferase mu (GST-?? and Glutathione S-Transferase alpha (GST-?? in an organ culture paradigm as well as the role of metalloproteases (MMPs) and their tissue inhibitors in photoreceptor degeneration (TIMPs). The rd1 mouse model …
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GENETICS OF GROUP 14 HERBICIDE TOLERANCE IN LENTIL
… among the candidate genes were cytochrome P450s, glutathione-S-transferases, some stress-related genes and50 genes involve in plant growth and development. This suggests that a non-target site resistance mechanism in combination with plant regrowth is the main cause for the observed differences in …
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The Mechanism of Cyanohydroxybutene Induced Glutathione Elevation: The Role of Gamma-Glutamylcysteine Synthetase
… mg/kg po) causes a 2- and 7-fold elevation in glutathione (GSH) in liver and pancreas, respectively. The mechanism of elevation is currently unknown. In an attempt to identify the mechanism of this GSH induction, the effect of CHB on hepatic and pancreatic $\gamma$-glutamylcysteine synthetase …
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Evaluation of the induction of rat hepatic and pancreatic glutathione S-transferases by treatment with the cruciferous nitrile, cyanohydroxybutene
… by inducing detoxifying including the glutathione S-transferase isoenzymes (GSTs). The GSTs catalyze the conjugation of glutathione (GSH) to electrophilic xenobiotics. As peroxidases, they detoxify organic hydroperoxides. Each isoenzyme has a unique level of activity in detoxifying …
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Characterization of Smooth Muscle Myosin Light Chain Kinase Using Crystallization and Transient Kinetics
… actin-binding domain of MLCK (called N1-75) with glutathione S-transferase (GST) was attempted in order to provide such a model. Polyethylene glycol and ammonium sulfate, within a pH range of 6.5 to 8.0, seemed to be the most promising precipitants to induce crystallization. Observation of …
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