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Showing 1 to 16 of 16 for “"glutathione synthesis"”.
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Use of Genetically Encoded Tools to Interrogate Mechanisms of Glutathione Homeostasis from Mitochondria to Mice
<p>Glutathione is an evolutionarily ancient molecule that underlies many critical biological processes across all categories of life. It acts as a cofactor in some metabolic reactions, modifies proteins to modulate their activity, and participates in detoxification of xenobiotic compounds. Despite …
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Topographical Differences in Stress Vulnerability in Experimental Parkinson's Disease
… exhibited higher levels of the antioxidants glutathione and ceruloplasmin, and loss of glutathione synthesis rendered neocortex as vulnerable to proteotoxicity as allocortex. Consistent with these observations, allocortex was protected against proteotoxicity by facilitating glutathione …
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Trim24 Promotes Mammary Tumor Development By Upregulating Metabolic Reducing Power
… of one-carbon metabolism and <em>de novo </em>glutathione synthesis pathways were upregulated in <em>Trim24</em><sup>COE</sup> spheroids and that upregulation was depended on TRIM24 over expression. NRF2 is a key regulator of cellular antioxidant response and often found over expressed in many …
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Characterization of Mechanisms That Mediate Cancer Metastatic Colonization
… allows for the diversion of metabolites towards glutathione generation—allowing for the maintenance of glutathione levels. Adequate glutathione levels appears critical for metastatic colonization as GCLC, the catalytic subunit of glutamatecysteine ligase and the rate-limiting enzyme for …
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TARGETING TYPE-I PRMTS RESTORES PLATINUM SENSITIVITY IN OVARIAN CARCINOMA THROUGH MITOCHONDRIAL METABOLISM
… with notable upregulation of nucleotide and glutathione metabolism and increased amino acid catabolism. This metabolic rewiring is associated with elevated NADPH production from the pentose phosphate pathway, supporting enhanced glutathione-mediated redox buffering. MS023 disrupts these …
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Bioavailability of blueberry-derived phenolic acid metabolites and their activity in endothelial cells
… modifier subunit (GCLM) which is important for glutathione synthesis. Blueberry-derived phenolic acid aglycones were able to significantly induce the expression of Nrf2-regulated HO-1 and GCLM proteins in HUVECs in the presence of a sub-lethal oxidative challenge presented by 2.5 μM H₂O₂. …
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Metabolically rewiring pancreatic stromal cells in pancreatic cancer
… proliferation. This limited cystine uptake, glutathione synthesis and anti-oxidant capacity of CA-PSCs and sensitised to oxidative stress. In a co-culture setting, inhibiting SLC7A11 in both PC cells and CA-PSCs significantly reduced colony number. We evaluated the therapeutic efficacy of two …
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Effect of Estradiol on xc- in Human Breast Cancer Cells
… the cell is the rate limiting precursor for glutathione synthesis and therefore regulates cellular defense against oxidative stress. The drug sulfasalazine (SASP) has been shown to specifically inhibit this system leading to cell stasis and glutathione depletion. Using the ER positive human …
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Prevention of Acute Pancreatitis by Broccoli Components
… CHB) to male F344 rats upregulates both glutathione synthesis and apoptosis in pancreas. Furthermore, studies conducted in CD-1 mice suggest that induction of apoptosis by acute iv CHB may reduce the severity of experimental acute pancreatitis. Therefore, we hypothesized that dietary …
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Microenvironmental and metabolic influences in tumor cell redox homeostasis
… of the mitochondrial matrix in hypoxia. The glutathione system functions in antioxidant defense and xenobiotic detoxification to preserve subcellular redox poise and maintain enzymes in functional reduced states. Glutathione is produced from its constitutive amino acids in a two-step …
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The effect of acute alcohol exposure on hepatic oxidative stress and function: prevention by micronutrients
… at 2.5 hr post-alcohol as evidenced by decreased glutathione levels and increased malondialdehyde levels in both the cytosol and mitochondria. Liver function was also depressed but there were no findings of apoptosis as cytochrome c levels and caspase 3 activity was unchanged. At 6 hours, the …
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Repurposing non-antimicrobial drugs to treat multi-drug resistant bacterial and fungal infections
… pathways including DNA, protein and cell wall synthesis. Furthermore, auranofin was found to be efficacious in a mouse model of <em>S. aureus</em> systemic infection, as it significantly reduced the bacterial load in murine organs, including the spleen and liver. Ebselen, an organoselenium …
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The impact of oxidative stress and potential antioxidant therapy on function and survival of cultured pancreatic β-islet cells
… protection against ROS-mediated damage.<br/>Glutathione is a crucial endogenous intracellular antioxidant that is tightly controlled by enzymes involved in its synthesis, utilization and breakdown. There is strong evidence of changes in glutathione peroxidase or total GSH levels, but little …
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TARGETING REDOX IN AGING AND ALZHEIMER'S DISEASE
… electron donor for many redox reactions, glutathione (GSH) is the major ROS detoxifying redox buffer within the cell and cysteines are the major reducing buffer in the extracellular matrix. Since the relationship of the prominent ROS damage to aging and AD is unclear, we wanted to know …
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THE ROLE OF NRF2 IN PREVENTING OXIDATIVE/ELECTROPHILIC STRESS-INDUCED LIVER INJURY
… that genes induced by Nrf2 are involved in glutathione synthesis, oxidation/reduction using NADPH as the co-factor, and xenobiotic metabolism. Moreover, mRNA of genes involved in the pentose phosphate pathway and malic enzyme levels had a clear dose-dependent correlation to active levels of …
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CHCHD2 and the tumor microenvironment in glioblastoma
… U87vIII CHCHD2 WT cells. The redox state of the glutathione (GSH) pool was more reduced within the mitochondrial matrix of CHCHD2 KO cells compared to WT cells, an effect independent of GSH synthesis, cystine import via xCT, or GPx-1, GPx-2, or GPx-4 levels. The cytosolic GSH pool was not …