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Showing 1 to 20 of 559 for “"glutathione"”.
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Glutathione regulation during exercise: Effect of fasting-refeeding, glutathione depletion and supplementation
Glutathione (GSH) is an important intracellular and extracellular antioxidant, critical for the organism's protection against reactive oxygen species. Since prolonged aerobic exercise has shown to increase formation of reactive oxygen species, this thesis investigated the importance of GSH during …
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Glutathione metabolism of Plasmodium falciparum
… of resistance in the future. The tripeptide glutathione (GSH) or γ-glutamylcysteinyl-glycine is the most abundant low molecular weight thiol in most eukaryotic organisms and serves a number of important functions as sulfhydryl-buffer, cofactor for enzymes and for the detoxification of …
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Tumor Cell Glutathione Metabolism: Therapeutic Implications
… A third approach involved inhibition of glutathione reductase (GR) with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Here too, interference in tumor cell GSH metabolism enhanced cytolysis by a flux of H<sub>2</sub>O<sub>2</sub>. In contrast, inhibition of catalase with aminotriazole had …
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Investigating the role of glutathione and glutathione biosynthetic genes in the adaption of Anopheles gambiae to insecticides
… resistance mitigates these approaches. Glutathione (GSH) is widely distributed among all living organisms, and is associated with detoxification pathways, especially the Glutathione S-transferases (GSTs). Its direct involvement and relevance in insecticide resistance in <i>An</i>. …
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Glutathione Peroxidase as an Oxidative Defense Enzyme
Made available in DSpace on 2014-12-14T15:33:40Z (GMT). No. of bitstreams: 1 8026545.pdf: 5506101 bytes, checksum: 4006284f11b892e40c45b29a3165d1fe (MD5) Previous issue date: 1980
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Glutathione utilization in lactobacillus fermentum CECT 5716
Glutathione, a tripeptide antioxidant, has recently been shown to be either utilized or synthesized by gram-positive bacteria, such as Lactic Acid Bacteria. Glutathione plays an important role in countering environmental stress, such as oxidative stress. In this study, cellular activity regarding …
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Comparing glutathione peroxidase and glutathione reductase activity and their associations with cardiovascular measures in Africans and Caucasians : the SABPA study
… remodelling. The endogenous antioxidant enzymes glutathione peroxidase and glutathione reductase work synergistically to maintain intracellular redox balance. Both these enzymes have been indicated to have varying levels of activities with changes in blood pressure. Furthermore, GPx activity was …
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Glutathione synthetase: Conserved residues of the substrate loop
The important antioxidant tripeptide glutathione (GSH) is synthesized in two ATP-dependent steps; the second enzyme in the biosynthetic pathway, glutathione synthetase (GS), ligates glycine to γ-glutamylcysteine (γ-GC). Human glutathione synthetase (hGS) deficiency causes hemolytic anemia, …
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The glutathione S-transferases : kinetics, binding and inhibition
The glutathione S-transferases are a group of enzymes which catalyse the conjugation of reduced glutathione with a variety of electrophilic molecules, and they are therefore thought to play a major role in drug biotransformation and the detoxification of xenobiotics. The cytosolic GSH S-transferase …
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Glutathione Dynamics in Arabidopsis Seed Development and Germination
… have great potential for oxidative stress. Glutathione, one of the most abundant antioxidants in plant cells, is a crucial to the plant's defense mechanisms. To better understand glutathione's responses during these two stages, we examined its dynamics in wildtype Arabidopsis seeds and in a …
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Metabolic Manipulation of Glutathione as an Anticancer Therapeutic Target
… H2O2 is of apparent importance, highlighting glutathione, the most abundant intracellular antioxidant, as a potential determinant of cancer survival following palmitoylcarnitine. The purpose of this dissertation was to first determine the response of glutathione to palmitoylcarnitine within …
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Studies on Glutathione Peroxidase of the Rat Gastrointestinal Tract
Made available in DSpace on 2015-05-12T22:36:30Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7514151.PDF: 2915447 bytes, checksum: 37da301df0cbf65b459a4f500e74f16c (MD5) Previous issue date: 1975
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The use of glutathione in canine itraconazole-associated hepatotoxicity
… and nitric oxide and decreases levels of hepatic glutathione (GSH) and other antioxidants. Based on this, antioxidant therapy could potentially prevent or treat ITZ-associated hepatotoxicity. Antioxidant hepatoprotectants are commonly used for a variety of liver diseases in veterinary medicine. …
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The Role of Glutathione Transferases in the Detoxification of TNT
… likely to be involved in these phases including glutathione transferases (GSTs). GSTs are known to detoxify compounds by conjugation to glutathione (GSH), and like UGTs are Phase II detoxification enzymes. This thesis presents an investigation into whether plant GSTs play a role in the …
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