Global ETD Search
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Showing 1 to 15 of 15 for “"glutarate"”.
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The use of enzyme catalysts in organic media for the synthesis of biodegradable polyesters
… reaction of bis(2,2,2-trichlorethyl) adipate and glutarate with butane-1,4-diol in anhydrous ether with and without molecular sieve was investigated over a range of times from 8 to 240 hours. The 72 hour adipate reaction with molecular sieve gave the highest molecular weight polymer (Mn 6,500 and …
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The intersection of metabolism and oxygen in T cell function and anti-tumour immunity
… three of which are centred around the metabolite glutarate, an oxygen sensitive metabolite with no known immunological function prior to this work. Chapter III identifies glutarate as an endogenous regulator of T cell function, demonstrating its capacity to enhance CD8+ T cell cytotoxicity and …
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The role of hypoxia in T cell function and immunotherapy
… and characterises the immunomodulatory role of glutarate, a newly discovered hypoxia-induced metabolite. Glutarate was found to inhibit α-ketoglutarate dependent reactions and to modulate T cell differentiation and improve antitumour CD8+T cell function. Administration of esterified glutarate in …
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Substrate specificity and functional characterization of sodium/dicarboxylate cotransporters
… exhibit large inward currents in the presence of glutarate, adipate, and succinate, whereas oocytes expressing rbNaDC1 have currents only with succinate. To identify NaDC1 domains involved in different ability to transport glutarate and adipate, I constructed a series of mNaDC1-rbNaDC1 chimeras, …
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Design and Synthesis of a Macrocyclic Phospholipid
… reacted with 10-undecyn-1-ol to produce a glutarate monoester. Copper-mediated azide-alkyne coupling (CuAAC) using 1,5-diazido-3-oxapentane(bis-azide) afforded a dicarboxylicacid with a hydrophobic chain of sufficient length to span a 35 Å bilayer membrane. The carboxylic acids were each …
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Design and Synthesis of Complex and Fluorescent Labeled Cellulose-Based Derivatives for Orally Administered Drug Delivery Systems
… and carboxylic acid content (cellulose acetate glutarate, 5-carboxypentyl hydroxypropyl cellulose, and hydroxypropyl methyl cellulose acetate succinate as positive control) by using in vitro dissolution studies. In this screening process, I determined that cellulose acetate glutarate provides …
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Cloning and characterization of organic anion systems in the adrenal cortex and their role in steroid release
… could be inhibited by probenecid. Cortisol, glutarate and PAH in the incubation medium also cis-inhibited 3H-PAH uptake, and preincubation with PAH trans-stimulated 3H-PAH uptake. Preliminary studies on human adrenocortical cells also provided evidence for the existence of a probenecid …
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Amphipathic Hybrid Cyclic-Linear Peptides as a Drug Delivery System
… conjugated to Peptide (2) through a β-alanine, glutarate linker, resulting in [R<sub>5</sub>W<sub>4</sub>]K–RRWWRLWRRLWRβA–DOX (<strong>4</strong>). Antiproliferative assays compared the efficacy of the peptide-DOX conjugate (PDC) to free DOX and its peptide-DOX physical mixtures in cancer cell …
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The use of enzymes in organic solvents in polytransesterification reactions
… trichloroethyl) adipate and glutarate systems in diethyl ether, with and without molecular sieves. It was found that molecular sieves promoted the reaction by reducing hydrolysis of the ester end-groups, resulting in polymer molecular weights between 1.2 and 2.2 times greater …
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Thermotolerant purple nonsulfur bacteria from New Zealand geothermal areas
… a pathway that includes 6-hydroxynicotinate and glutarate as intermediates, as are in the Azorhizobium caulinodans pathway. Unlike other nicotinic-acid degrading organisms, growth of Rhodoplanes on nicotinate was not inhibited by addition of tungstate.
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Computational and Pharmacological Approaches to Design Novel Allosteric Thymidylate Synthase Inhibitors
… and/or by decreasing protein stability. Glutarate (GLU), an allosteric inhibitor, caused downregulation in TS levels, which is the first TS inhibitor reported to decrease TS levels. To obtain novel allosteric TS inhibitors, two approaches were employed. </p> <p> Firstly, a new nucleotide …
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Inorganic and organic speciation of atmospheric aerosols by ion chromatography and aerosol chemical mass closure
… succinate (3%), MSA- (4%), malonate (2-9%), glutarate (7-26%). With regard to the four DCAs, oxalate was always the most prevailing. The carbon in the sum of the four DCAs accounted for 3-7% of the WSOC. Aerosol chemical mass closure was performed with the IC data in combination with …
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Amphiphilic Cyclic Cell-Penetrating Peptides Containing Tryptophan and Arginine as Anticancer Agents and Drug Delivery System
… chain amino group of β-alanine with Dox via a glutarate linker to afford [(WR)8WK]bA-Dox conjugate. The conjugate inhibited the cell viability of ovarian adenocarcinoma (SK-OV-3) by 59% and triple-negative breast cancer cells, MDA-MB-231 and MCF-7, by 71% and 77%, respectively, at a …
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Neutral receptors for anion recognition: synthesis, selectivity studies and transport properties
… towards different anions (acetate, benzoate, glutarate, malonate, dihydrogen phosphate, hydrogen pyrophosphate, triphosphate, AMP and ADP) have been studied by means of 1H-NMR, UV-Vis and fluorescence spectroscopies and a remarkable affinity for HPpi3- has been observed in the case L5 (in …
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Design and Evaluation of Cyclic Peptide-Epirubicin Conjugate for Enhanced Anticancer Activity and Reduced Myocardial Toxicity
… with [(WR)<sub>4</sub>WK]bA through a glutarate linker.</p> <p>The cytotoxicity of the conjugate, physical mixture, and EPI alone were compared at different concentrations in ovarian adenocarcinoma (SK-OV-3), breast adenocarcinoma (MCF-7) triple-negative breast (MDA-MB-231), …