Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"glutaminolysis"”.
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The effects of the modification of energy metabolism on cellular response to ionizing radiation
… are initially metabolised via glycolysis and glutaminolysis, respectively, before their products are further metabolised in respiration. Since energy is necessary for repair of radiation damage, it has been proposed that the inhibition of energy metabolism might alter the radiation response of …
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A Study On The Function of 14-3-3Sigma In Regulating Cancer Energy Metabolism
… against anti-cancer therapies. Glycolysis, glutaminolysis and mitochondrial biogenesis are among the most essential cancer metabolic alterations because these pathways provide cancer cells with not only energy but also crucial metabolites to support large-scale biosynthesis, rapid …
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Signaling pathways and novel therapeutic strategies for the treatment of murine chronic graft versus host disease
… for glycolysis, fatty acid synthesis and glutaminolysis are all required by donor T-cells for development of cGVHD. Targeting Glutaminolysis for pharmacologic inhibition in particular was found to be an effective therapeutic for cGVHD. We determined that targeting the germinal center …
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Modulation of macrophage metabolism and function by the helminth peptide FhHDM-1
… by fatty acids and supported by the induction of glutaminolysis. These changes mediated a decrease in glycolytic flux which consequently reduced pro-inflammatory cytokine production. This regulation of macrophage metabolism was maintained in vivo and furthermore, led to the reduction of histone …
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The Tca Cycle As A Nexus of Metabolic Vulnerabilities In Cancer
… impairing the breakdown of nutrients (glycolysis/glutaminolysis inhibition), or by restricting the import of blood-borne nutrients (angiogenesis inhibition), or by targeting coenzyme biosynthesis (acetyl-CoA for TCA cycle), can selectively impair cancer cell viability <em>in vitro</em> and in …
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Quantitative analysis of carbon fluxes for fat biosynthesis in wild-type and IRS-1 knockout brown adipocytes
… to fatty acid synthesis have been proposed: glutaminolysis pathway through conventional tricarboxylic acid cycle and a pathway via reductive carboxylation of a-ketoglutarate to isocitrate. These pathways were integrated into a metabolic network model for quantitative estimation of individual …
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Microenvironmental and metabolic influences in tumor cell redox homeostasis
… reprogramming of transformed cells. Oncogenic glutaminolysis results in glutamine utilization that far exceeds the anabolic needs of transformed cells for nitrogen and increases the anaplerotic flux of glutamine through the TCA cycle to support mitochondrial respiration. MYC and RAS-transformed …
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Investigating the interdependence of human BH3-only protein Noxa and glutamine in activated CD8+ T cells.
… Silencing of Noxa through siRNA interferes with glutaminolysis but does not impair mitochondrial respiration, suggesting a switch by the T cells to an alternative fuel source for energy generation. Thus, human BH3-only protein Noxa not only facilitates the entry of glutamine into the TCA cycle …
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Ionic Mechanism of Lysosomal Function and Cell Metabolism
… that ammonia generated during GLS1/2 mediated glutaminolysis regulates lysosomal pH in a dose-dependent manner. In mouse embryonic fibroblast (MEF) cells, as well as immortal cell lines, including L929 and HeLa cells, deprivation of total amino acids for 1 hour increased lysosomal degradation …
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Myc influences glutamine metabolism to induce autophagy in tumorigenesis
… macromolecules, by modulating glycolytic flux, glutaminolysis, lipidogenesis, and autophagy. The process by which hyperproliferative cells undergo metabolic reprogramming to sustain growth can be recapitulated in the epithelial cells from Drosophila imaginal discs, where different levels of Myc …
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Characterization of Novel Liver X Receptor Inverse Agonist in Breast Cancers
… with 1E5 has been demonstrated to inhibit glutaminolysis and induce oxidative stress. Additionally, LXRβ transcript levels are upregulated in breast cancer patient tissue. Therefore, we posit that characterization of the effects of 1E5 in breast cancer can reveal potential antitumor …
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The development of novel metabolic therapies for the treatment of glioblastoma
… of tumour biopsies, while those involved in glutaminolysis (GLS1, GLS2) were near-universally downregulated. In summary, the data of this thesis reinforced HK2’s potential as a therapeutic target for disrupting glioblastoma glycolysis, while also highlighting co-targets that could be …
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Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Carcinoma
… and MYC overexpression is known to stimulate glutaminolysis and lipogenesis. In HIF1A repressed cells that overexpress MYC, genes involved in these pathways are further up-regulated at hypoxic conditions. Taken together, our data indicate that the adaptive capacity to hypoxia is partially …
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Regulation of neutrophilic inflammation by hypoxic signalling pathways
… increased protein uptake and increased glutaminolysis. Utilising heavy labelled protein extracts, I have traced breakdown products from scavenged proteins into central carbon metabolism, demonstrating that extracellular protein can fuel neutrophilic inflammation. Finally, I have …