Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"glutamic acid decarboxylase"”.
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Glutamic Acid Decarboxylase and the Gamma-Aminobutyric Acid Pathway in the Supraesophageal Ganglion of the Honeybee, Apis Mellifera (Hymenoptera, Apidae)
Made available in DSpace on 2014-12-11T18:05:31Z (GMT). No. of bitstreams: 1 7105098.pdf: 3708700 bytes, checksum: fe7964e6cd4b948a191c97559688f42f (MD5) Previous issue date: 1970
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Functional relationship between forebrain cholinergic projections and somatostatin neurons in the rat
… types of neurons was investigated using folic acid, a neuro-excitant, and cysteamine, a somatostatin depleter. Folic acid causes a neuron to fire at a much higher rate than normal (Spector, 1971). Folic acid was injected into either the septum or the substantia innominata, and the long-term …
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cholera Toxin B Subunit-Diabetes Autoantigen Fusion Proteins Modulate Dendritic Cell Function and T Cell Morphogenesis
… inflammatory disease in which the insulin and glutamic acid decarboxylase producing β-cells of the pancreatic islets are killed by autoreactive cells of the immune system in response to a loss of tolerance. Early experiments showed that self-tolerance could be partially restored by oral …
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Plant-delivered Cholera Toxin B subunit as an Immunomodulatory Molecule
… inoculation of cholera holotoxin. A 22-amino acid rotavirus enterotoxin NSP4 epitope was fused at the C-terminus of the CTB subunit. Transgenic potato tubers synthesized up to 0.1% of total soluble protein as the pentameric CTB-NSP4 fusion peptide.</p> <p>To prevent IDDM, we generated …
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Neuronal Nitric Oxide synthase regulates the expression of EAAT4 and GAD65/67 in the murine cerebellum
… nNOS/NO signaling regulation of excitatory amino acid transporter 4 (EAAT4) on PN dendrites and glutamic acid decarboxylase (GAD) expression/function between sexes by using wildtype (WT) and nNOS-/- mice at different postnatal developmental time points. This study revealed that there are gene- and …
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Revised - THE ROLE OF GAD67/65 IN THE THERAPEUTIC EFFECTS OF KETAMINE AND FLUOXETINE IN FEAR-CONDITIONED MICE
… altered levels of GABA, its receptors, and glutamic acid decarboxylase (GAD65/67); its rate limiting enzyme. GABAergic interneurons function as essential regulators of fear memory through their direct inhibitory influence on excitatory pyramidal cells (PCs) throughout the amygdala, …
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Altered GABA ergic system in the posterior hypothalamus of the spontaneously hypertensive rat
… as well. Based on immunocytochemistry for glutamic acid decarboxylase, the synthesizing enzyme for GABA, this enhanced activity in the SHR is most likely due to a ""disinhibition"" of the PH resulting from a decreased number of GABA-synthesizing neurons in this area. Neuronal responses to …
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The genetic background of gestational diabetes mellitus
… presence of islet cell autoantibodies against glutamic acid decarboxylase 65 (GAD65), insulinoma-associated antigen 2 (IA-2) and insulin in women who had been diagnosed with GDM at least once during 2000-2004. The HLA-DQB1*0602 allele which is considered to be protective for type 1 diabetes had …
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Investigating the protective effects of intestinal GABA[subscript A] receptor activation on an animal model of Multiple Sclerosis
<p>Gamma aminobutyric acid (GABA) is an inhibitory neurotransmitter, produced by neurons in the central nervous system (CNS) and by some species of intestinal bacteria. GABAA receptors are found not only in the CNS, but also in T cells and within the intestines. Past studies have indicated that …
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Effects of GABA on inflammation and intestinal barrier disruption
… reducing frequencies of gamma-aminobutyric acid (GABA)-producing bacteria. GABA levels are reduced in the brains and circulation of MS patients. We engineered Lactococcus lactis with extra copies of gadB (glutamic acid decarboxylase) and gadC (glutamate/GABA antiporter) to increase GABA …
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Regulation of Molecular Composition at Glutamatergic Synapses
… cultures, corresponding with a low level of glutamic acid decarboxylase (GAD, the synthetic enzyme for GABA), exhibited far fewer synaptic NMDAR clusters compared to high density cultures, corresponding with a high level of GAD expression. An correlation between GABAergic innervation and …
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Structural And Chemical Organization Of The Rat Interpeduncular Nucleus
… and terminals stained immunohistochemically for glutamic acid decarboxylase (GAD) were present in the rostral, lateral, central and intermediate subnuclei. Axodendritic and axosomatic synapses possessing GAD immunoreactivity pre - and/or postsynaptically were evident in these subnuclei. …
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DISRUPTION OF THE HIPPOCAMPAL GABAERGIC SYSTEM IN THE Fgf14 ̶ / ̶ MOUSE MODEL
… the functional integrity of gamma-amino-butyric acid (GABA) interneurons. These inhibitory interneurons modulate synaptic plasticity and intrinsic excitability of principal neurons balancing the excitatory/inhibitory ratio in the brain. Reduction in parvalbumin interneurons (PVIs) and GABAergic …
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Role of serotonin2C receptor (5-HT2CR) in expression of cocaine-induced conditioned hyperactivity
… About half of neurons with 5-HT2CR-IR expressed glutamic acid decarboxylase (GAD) 67-IR, a marker of GABA interneurons. Among subpopulations of GABA interneurons, a significantly higher percentage of neurons expressing parvalbumin-IR also expressed 5-HT2CR-IR compared to other subpopulations. …
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Engineering Secreted Proteins for Gene Transfer and DNA Vaccination
… this work,<em> Renilla</em> luciferase and human glutamic acid decarboxylase (GAD) 65 were engineered for secretion to address some aspects of these issues.</p> <p>Secreted reporter proteins are promising tools to study gene transfer and expression in a non-destructive manner, and bioluminescent …
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Heterologous Expression of Alpha 6*- Nicotinic Acetylcholine Receptors and the Natural Distribution of Alpha 6 Subunits
… potential co-expression of nAChR α6 subunits and glutamic acid decarboxylase (GAD) or tyrosine hydroxylase (TH) as labels of GABAergic and dopaminergic/catecholaminergic neurons respectively, using tandem mRNA FISH and fluorescence immunohistochemistry. nAChR α6 subunit signal in the substantia …
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Gestational Diabetes Mellitus- Future risk for mother and child
… have beta-cell specific autoantibodies such as glutamic acid decarboxylase antibodies (GADA), tyrosine phosphatase antibodies (IA-2A) and zink transporter 8 antibodies (ZnT8A) during pregnancy, and follow these women after delivery to estimate the risk for later development of type 1 diabetes. …
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Immunoregulatory differences between adult onset type 1 diabetes and latent autoimmune diabetes in adults (LADA)
… but not LADA. Autoantibodies directed against glutamic acid decarboxylase 65 (GADA) were predominantly of the IgGl subclass in both adult onset type 1 diabetes and LADA. Moreover, the IgG4 subclass was the second most common subclass in LADA but below detection limit in type 1 diabetes at …
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Genetic and immunological risk factors of gestational diabetes mellitus
… that GDM was associated with the presence of glutamic acid decarboxylase-65 antibodies (GAD65Ab) in Arabian and Scandinavian women. In addition, Scandinavian women with GDM were found to share some genetic features such as HLA DQB1 risk genotypes (odds ratio [OR] 1.36, [95% CI 1.03?1.79], …
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