Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"glutamatergic system"”.
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IMAGING THE GLUTAMATERGIC SYSTEM WITH GLUCEST MRI: CYTOARCHITECTURE, AGING, AND INTERVENTION
… in neurons and astrocytes. Shifts in glutamatergic biology can both reflect and drive changes in circuit excitability, synaptic structure, glial function, and cellular metabolism, providing a mechanistic bridge from cellular perturbations to systems-level phenotypes including aging and …
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Neuroadaptive Changes in the Mesocortical Glutamatergic System during Nicotine Self-administration and after Extinction in Rats
… the neuroadaptive changes in the mesocortical glutamatergic system during chronic nicotine self-administration (SA), which emulates important aspects of nicotine intake by humans, and after extinction. In the initial study, after 18 days of nicotine SA, in the medial prefrontal cortex (mPFC), …
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Neurochemical Effects of Concurrent Exposure to Repeated Stress and Chlorpyrifos on the Central Nervous System
… cause reversible impairment to the hippocampus. Glutamatergic and cholinergic systems were proposed to be involved in responses seen after exposure to stress and cholinesterase inhibitors. Effects of concurrent exposure to repeated stress and chlorpyrifos (CPF) on concentrations of excitatory …
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Glutamate Imaging of Mouse Models of Neurodegeneration
Malfunctions in the glutamatergic system of the central nervous system have been implicated in neurodegenerative diseases such as Alzheimer’s disease (AD), tauopathies, and Parkinson’s disease (PD). A non-invasive measurement of glutamate would enhance our understanding of neurodegenerative …
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Rapid neuronal responses during spreading neurotoxic and neuroprotective network activity
… in the mammalian central nervous system, playing critical roles in basal synaptic transmission and the molecular correlates of learning and memory, long-term potentiation and long-term depression. However, glutamate is also neurotoxic during prolonged exposure and the dysfunction …
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Neuroinflammation, Glutamate Regulation and Memory
Neuroinflammation and excessive glutamatergic signaling have deleterious effects in the brain, are mutually promoting, and play a role in the onset and progression of neurodegenerative diseases. It was my goal to better understand the relationship between neuroinflammation, glutamate dysregulation …
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Investigation of the functional effects of two novel ampakines in the CNS
… (‘Ampakines’) are known to positively modulate glutamatergic AMPA receptor-gated currents, by slowing the deactivation and desensitisation rate of the receptors, in the presence of the endogenous agonist glutamate. Ampakines have been shown to facilitate LTP induction, improve cognition, and as …
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INVESTIGATIONS INTO THE STEREOCHEMICAL AND GLUTAMATERGIC MECHANISMS OF THE "BATH SALTS" SYNTHETIC CATHINONES MEPHEDRONE AND MDPV IN RATS
… stereospecific mechanisms in the monoaminergic systems, as well as the role of the glutamatergic system in mitigating reward, reinforcement, and relapse to drug seeking. We first evaluated MEPH’s ability to produce behavioral sensitization (detailed in Chapter 2), a hallmark behavior of …