Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"glutamatergic synapse"”.
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Calcium sensitivity of neurotransmitter release in a glutamatergic synapse of the central nervous system
Der Signalübertragung an chemischen Synapsen liegt ein Kopplungsmechanismus zwischen dem präsynaptischen Aktionspotential und der biochemischen Überträgerstoff-Ausschüttung zu Grunde. Dabei werden Ca2+-Kanäle geöffnet und ein Freisetzungssensor Ca2+-abhängig aktiviert, der schließlich die …
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Astrocytic Contribution to the Glutamatergic Transmission in Schizophrenia
… with schizophrenia, focusing specifically on the glutamatergic abnormalities in the hippocampus, one brain region repeatedly found to bear structural, molecular, and blood flow abnormalities in the disease. I have started with the in vivo measurement of glutamate and glutamine using magnetic …
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Influence of Prion Protein Expression on Function of Excitatory Amino Acid Transporters in Mouse Primary Astrocytes
… suggestive that PrP may function in the glutamatergic synapse. Here we show that transport of D-aspartate, a non-metabolized L-glutamate analog, through excitatory amino acid transporters (EAATs) was faster in astrocytes from PrP knockout (PrP KO) mice than in astrocytes from C57BL/10 SnJ …
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Influence of Prion Protein Expression on Function of Excitatory Amino Acid Transporters in Mouse Primary Astrocytes
… suggestive that PrP may function in the glutamatergic synapse. Here we show that transport of D-aspartate, a non-metabolized L-glutamate analog, through excitatory amino acid transporters (EAATs) was faster in astrocytes from PrP knockout (PrP KO) mice than in astrocytes from C57BL/10 SnJ …
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Nociception and the Experience of Pain Signaling Due to Nerve Damage
… proteins for NMDAr at integration and motor synapses of spinal cord tissues. The FIM values were then correlated to the presence of NMDA, or PSD95 on spinal neurons to indicate production and assembly of glutamatergic synapse components, eluding to colocalization of NMDA receptor and its …
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Identification of estrogen-regulated genes in the cerebral cortex and development of a novel method to detect methylated DNA
… These E2-regulated genes were involved in glutamatergic synapse maintenance, axon guidance, angiogenesis, cell adhesion, apoptosis, development, lipid regulation, transcriptional control, and signaling pathways. The gene expression changes in both normoxic and hypoxic conditions reveal the …
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Synapse Dysfunction Induced by Autism Spectrum Disorder Associated Shank3 Mutations
… investigations into understanding the roles of synapse dysfunction in the pathogenesis of ASD. Shank3 is a postsynaptic scaffolding protein that is essential to regulating both the function and structure of excitatory synapses and Shank3 genetic mutations have been described in people affected …
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Epac-mediated modulation of neurotransmitter release from cultured hippocampal neurons
cAMP beeinflusst sekretorische Prozesse sowohl durch Protein Kinase A (PKA)-abhängige als auch durch PKA-unabhängige Signaltransduktionsprozesse. Dennoch ist der jeweilige Anteil an einer cAMP-vermittelten Regulation der Neurotransmission nur unzureichend bekannt. In verschiedenen Preparationen von …