Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 207 for “"glutamatergic"”.
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Organisation of Glutamatergic Inputs to Central amygdala
Chronic pain is a major public health problem, leading to long term disability and distress that makes its clinical management challenging. Central amygdala (CeA) is a key neural substrate that contributes in the control of the pain response and modulates the affective-motivational component of …
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Regulation of Molecular Composition at Glutamatergic Synapses
… is necessary for the formation of functional glutamatergic synapses. Here I examined the clustering of presynaptic (Brain-Specific L-Proline Transporter, PROT) and postsynaptic (N-Methyl-D-Aspartate Glutamate Receptor, NMDAR) molecular markers in rat hippocampal cultured neurons. PROT …
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Astrocytic Contribution to the Glutamatergic Transmission in Schizophrenia
… with schizophrenia, focusing specifically on the glutamatergic abnormalities in the hippocampus, one brain region repeatedly found to bear structural, molecular, and blood flow abnormalities in the disease. I have started with the in vivo measurement of glutamate and glutamine using magnetic …
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Enhanced striatal glutamatergic function upon chronic antipsychotic action
… chronic antipsychotic administration enhances glutamatergic function in the ventral striatum through translational alterations and increased synaptic function. Cell type-specific mRNA profiling on spiny projection neurons (SPNs) of the direct (dSPNs) and indirect (iSPNs) pathways following …
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Synaptome mapping of glutamatergic synapses across the mouse brain
… between neurons. At postsynaptic terminals of glutamatergic synapses, protein complexes process and transmit the information received from the presynaptic terminal. Scaffolding proteins, among which members of the disc large homologue (DLG) family are the most abundant, assemble the molecular …
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Unmasking Impulsivity as a Glutamatergic Dysfunction Phenomenon: Presynaptic and Postsynaptic Considerations
… of preclinical studies that aimed to examine glutamatergic presynaptic and postsynaptic neural substrates in key brain regions underlying motor impulsivity. Impulsivity is thought to be a function of a cortical imbalance that results in excessive “go” signaling (i.e. loss of inhibitory …
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Investigation of Glutamatergic Circuitry Underlying Copulatory Reward in Female Syrian Hamsters
… determined the involvement of excitatory glutamatergic efferents from the medial prefrontal cortex (mPFC) to the NAc. Then, to determine if mPFC activity was driving the activation of the NAc during female sexual behavior, I employed designer receptors exclusively activated by designer …
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Evaluation of Glutamatergic Treatment in Reducing Nicotine Seeking Behavior in Rats
Although pharmacotherapy and psychosocial support can help smokers to quit, the high relapse rates indicate a high unmet need for more effective treatment. Recent studies have highlighted changes in glutamate (GLU) homeostasis in the circuitry from the prefrontal cortex (PFC) to the nucleus …
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IMAGING THE GLUTAMATERGIC SYSTEM WITH GLUCEST MRI: CYTOARCHITECTURE, AGING, AND INTERVENTION
… in neurons and astrocytes. Shifts in glutamatergic biology can both reflect and drive changes in circuit excitability, synaptic structure, glial function, and cellular metabolism, providing a mechanistic bridge from cellular perturbations to systems-level phenotypes including aging and …
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Simulating the Affects of Glutamatergic Afferents on the Firing Pattern of Midbrain Dopamine Neurons
… AMPA and NMDA. In a diagonal band where average glutamatergic and tonic gabaergic input is roughly balanced, both single spike firing and bursting can be observed. Simulated SK channel block strengthens the correlation between pattern and rate and increases the number of spikes fired in bursts by …
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Calcium sensitivity of neurotransmitter release in a glutamatergic synapse of the central nervous system
Der Signalübertragung an chemischen Synapsen liegt ein Kopplungsmechanismus zwischen dem präsynaptischen Aktionspotential und der biochemischen Überträgerstoff-Ausschüttung zu Grunde. Dabei werden Ca2+-Kanäle geöffnet und ein Freisetzungssensor Ca2+-abhängig aktiviert, der schließlich die …
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Neuroadaptive Changes in the Mesocortical Glutamatergic System during Nicotine Self-administration and after Extinction in Rats
… the neuroadaptive changes in the mesocortical glutamatergic system during chronic nicotine self-administration (SA), which emulates important aspects of nicotine intake by humans, and after extinction. In the initial study, after 18 days of nicotine SA, in the medial prefrontal cortex (mPFC), …
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Studies on the effect of growth hormone on age-related changes in glutamatergic transmission in the hippocampus
… is mediated primarily by the AMPA and NMDA glutamatergic receptors, and these receptors are important for the basal synaptic transmission and long term potentiation (LTP) that underlie learning and memory processes. Cognitive function has been reported to decline with age, as reflected by a …
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INVESTIGATIONS INTO THE STEREOCHEMICAL AND GLUTAMATERGIC MECHANISMS OF THE "BATH SALTS" SYNTHETIC CATHINONES MEPHEDRONE AND MDPV IN RATS
… systems, as well as the role of the glutamatergic system in mitigating reward, reinforcement, and relapse to drug seeking. We first evaluated MEPH’s ability to produce behavioral sensitization (detailed in Chapter 2), a hallmark behavior of psychostimulants involving repeated, …
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Prdm13, a Direct Downstream Target of Ptf1a, Regulates the Balance of Gabaergic Neurons versus Glutamatergic Neurons in the Dorsal Spinal Cord
… interneurons 3-5) and is required for the glutamatergic neuronal fate. In contrast, another bHLH factor Ptf1a, is restricted in progenitors to dI4 and is required to specify the GABAergic neuronal fate. Since progenitors to dI4 express both Ascl1 and Ptf1a, some mechanism must exist to …
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Functional properties and Ca2+-dependent feedback modulation of voltage-gated Ca2+ channels in glutamatergic nerve terminals of the mammalian auditory brainstem
Die funktionellen Eigenschaften vieler präsynaptischer Nervendigungen der Säugetiere sind noch weitgehend unbekannt, da die meisten Nervendigungen des Zentralnervensystems für elektrophysiologische Messungen nicht direkt zugänglich sind. In der vorliegenden Arbeit wurden funktionelle Eigenschaften …
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Investigating Sex-Specific Responses in a Preclinical Model of Traumatic Brain Injury: Development of Chronic Depression-Like Behavior and Glutamatergic Protein Changes
… symptoms than males following injury. Altered glutamatergic neurotransmission has been implicated as a possible cause of depression following concussion due to similarities in glutamatergic changes that occur following concussion and during depression, independently of brain injury. …
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A STUDY ON THE EFFECTS OF CHRONIC ALCOHOL AND WITHDRAWAL IN THE BASOLATERAL AMYGDALA OF SPRAGUE DAWLEY RATS: AFFERENT SPECIFIC MODIFICATION OF GLUTAMATERGIC NEUROTRANSMISSION
… behavioral responses. These nuclei receive glutamatergic input via two major pathways differentiated by their anatomical arrangement and the upstream brain areas giving rise to the pathways. The external capsule (EC) brings primarily cortical information while the stria terminalis/internal …
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MUNC13 PROTEINS REGULATE STRAIN-DEPENDENT EFFECTS OF ETHANOL-MEDIATED INHIBITION OF SYNAPTIC VESICLE RECYCLING
… withdrawal leads to long-term adaptations in glutamatergic transmission within the basolateral amygdala (BLA). We have also demonstrated that this hyperexcitable state contributes to the expression of withdrawal related anxiogenesis and can be ameliorated by glutamatergic antagonists. However, …
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Investigating neuroinflammation in schizophrenia: a proton magnetic resonance spectroscopy (1H-MRS) and cytokine study
… psychosis, with evidence of alterations in glutamatergic function in both conditions, and of involvement of inflammatory pathways in schizophrenia and methamphetamine abuse. Few studies have directly compared glutamatergic and inflammatory metabolites in thalamo-cortical circuitry across …
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