Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"glutamate transport"”.
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On the chloride dependence of vesicular glutamate transport
… Vesikel wird von den vesikulären Glutamattransportern (VGLUTs) durchgeführt. VGLUTs sind sekundär aktive Transporter, die einen protonenbasierten elektrochemischen Gradienten nutzen der von der vakuolären ATPase (VATPase) bereitgestellt wird. Biochemische Untersuchungen an isolierten …
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Evaluation of the Role of Astrocyte Glutamate Transport and of Synaptic NMDA Receptor Subtype Representation in the Pathogenesis of PTSD
… investigating the involvement of the astrocytic glutamate reuptake transporter, GLT-1, and regional differences in expression of NMDA receptor subtypes in the development of a rat model of PTSD. We hypothesized that impaired astrocytic glutamate reuptake inhibits long-term memory processes, and …
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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
Glutamate is the major excitatory neurotransmitter in the brain and is crucial for processes such as learning and memory. Due its importance as a signaling molecule, the extracellular glutamate concentration is tightly regulated, largely by the excitatory amino-acid transporters (EAATs). In these …
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Structure and function of glutamate transporters
… structural and functional features involved with glutamate transport by the excitatory amino acid transporters (EAAT1-5). This research derives from a study of X-ray crystal structures of an homologous archaeal transporter. Broadly, using computational methods to probe EAAT homology models born …
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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
Glutamate is the major excitatory neurotransmitter in the brain and is crucial for processes such as learning and memory. Due its importance as a signaling molecule, the extracellular glutamate concentration is tightly regulated, largely by the excitatory amino-acid transporters (EAATs). In these …
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Structure and function of glutamate transporters
… structural and functional features involved with glutamate transport by the excitatory amino acid transporters (EAAT1-5). This research derives from a study of X-ray crystal structures of an homologous archaeal transporter. Broadly, using computational methods to probe EAAT homology models born …
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Mechanisms of Astrocyte Contribution to Bortezomib-Induced Peripheral Neuropathy
… GLT-1, and GLAST to assess whether astrocytic glutamate transport may be altered in BIPN. The results observed in the first aim were that the rat BIPN model is characterized by selective mechanical hypersensitivity and a significant increase in wide dynamic range (WDR) neuron firing rates and …
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
L-Glutamate is the major excitatory neurotransmitter in the mammalian CNS that can mechanistically contribute to either neuronal signaling or neuronal pathology. Consequently, its concentration in the CNS must be carefully regulated, a critical need that is met by the excitatory amino acid …
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
L-Glutamate is the major excitatory neurotransmitter in the mammalian CNS that can mechanistically contribute to either neuronal signaling or neuronal pathology. Consequently, its concentration in the CNS must be carefully regulated, a critical need that is met by the excitatory amino acid …
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Identification and characterization of epithelial progenitor niches in skin
… and animal models revealed the presence of a glutamate transport to the HF via sensory nerve fibers. I elucidated that the presence of glutamate was critical for the organization of Schwann cells in the developing HF. Although the relationship between UI keratinocytes and PN still needs to be …
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Identifying novel therapeutic targets for seizures and brain cancers
… including the excitatory neurotransmitter glutamate. A subgroup of patients with epilepsy may not respond to systemic treatment and therefore would become candidates for surgical therapy. A less invasive approach is vagal nerve stimulation, which I demonstrated is safe and effective in 100 …
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Neuroinflammation, Glutamate Regulation and Memory
Neuroinflammation and excessive glutamatergic signaling have deleterious effects in the brain, are mutually promoting, and play a role in the onset and progression of neurodegenerative diseases. It was my goal to better understand the relationship between neuroinflammation, glutamate dysregulation …
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Study of the etiology of neurolathyrism, a human neurodegenerative disease with nutritional causes
… effect of L-β-ODAP was studied as compared to L-glutamate on the permeability of the blood-brain barrier (BBB), on the survival and functioning of neuronal and glial cells, and free amino acids were analyzed in urine of neurolathyrism patients. An in vitro model for the BBB, consisting of brain …
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Investigating the TrkB Interactome during Development and in Neurodegeneration
… was largely composed of cytoskeleton and transport vesicle-related proteins, as well as transmembrane transporters. At the synapse, in particular, small molecule transporters interacted with TrkB, including ion and glutamate transporting excitatory amino acid transporter 1 (EAAT1). BDNF …