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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 39 for “"glutamate release"”.

  1. Modulation of System x<sub>c</sub>- Mediated Glutamate Release in Glioblastoma Multiforme via the Extracellular Matrix: The Agony and the Xctasy

    Martin, Joelle DominiqueVirginia Tech2021

    … of extracellular cystine for intracellular glutamate. Clinical studies have shown areas immediately surrounding the tumor, known as the peritumoral region, reach glutamate concentrations over 100 times that of the normal brain, creating an excitotoxic environment in which neurons cannot …

    vt Repository record

  2. Glutamate Dysregulation in a TauP301L Mouse Model of Alzheimer's Disease

    Hunsberger, Holly C.2019

    … but recent work suggests tau may mediate glutamatergic signaling. Glutamate is the primary excitatory neurotransmitter in the central nervous system and changes in glutamatergic neurotransmission affect the overall activity of neuronal networks. Although beneficial at low levels, high …

    wvu Repository record

  3. Glutamate and MDMA Neurobehavioral Toxicity

    Anneken, John H.University of Cincinnati2012

    … evokes a well-documented acute increase in the release of serotonin, dopamine, and acetylcholine, as well as persistent reductions in markers of serotonin axon terminals across several brain regions. Little is known concerning the effect of MDMA exposure on the glutamatergic neurotransmitter …

    ohiolink Repository record

  4. The glutamate hypothesis of depression: the effect of stress and glucocorticoids on glutamate synapse and the action of antidepressants

    TRECCANI, GIULIAUniversità degli studi di Catania2012

    … and preclinical studies have demonstrated that glutamatergic transmission has a primary role in the pathophysiology of mood and anxiety disorders (MADI). It has been shown that in depressed patients the levels of glutamate and its metabolites are altered in plasma and in selected brain areas and …

    catania Repository record

  5. Role of Medial Prefrontal Cortical Group II Metabotropic Glutamate Receptor in the Development of Cocaine Sensitization

    Xie, Xiaohu2016

    … prefrontal cortical (mPFC) group II metabotropic glutamate receptors (mGluR<sub>2/3</sub>) in the development of cocaine sensitization. Initial studies demonstrated that intra-mPFC injection of the mGluR<sub>2/3</sub> receptor agonist, APDC, dose-dependently reduced acute behavioral response to …

    tenn-hsc Repository record

  6. Behavioural and Metabolic Characterization of NPR-9 and AIB Signaling Dynamics in Caenorhabditis Elegans

    Campbell, Jason2018

    … neuropeptide receptor NPR-9 and stimulatory glutamate gated cation channel receptor GLR-1 function in anterior interneuron AIB. npr-9 loss-of-function and over-expression mutants display abnormal spontaneous locomotion patterns. Hence, we evaluated npr-9 and AIB-specific glr-1 mutant …

    queens Repository record

  7. A Comparative Study of Sensory Neuron Synaptic Activity and the Role of Presynaptic Diversity, Specificity, and Regulation in Caenorhabitis Elegans

    Ventimiglia, Donovan

    … functions, we sought to characterize synaptic release in the stereotyped and defined neural circuitry of C. elegans. Here we use pHluorin imaging (Vglut-­pH) to monitor presynaptic glutamate release from single chemosensory neurons in intact animals and characterize the dynamics of endo-­ and …

    rockefeller Repository record

  8. Roles of interleukin-1 beta in glutamate-induced spinal cord injury

    Song LiuThe University of Texas Medical Branch2006

    Glutamate release contributes to the impairments caused by spinal cord injury (SCI). This study addresses the mechanisms of glutamate toxicity involving activation of interleukin-1â (IL-1â). To assess the effects of glutamate on IL-1â and its natural blocking agent interleukin-1 receptor antagonist …

    utmb Repository record

  9. Excitotoxic Injury Mechanisms in Central White Matter

    Doyle, Seán P.2017

    … of ischemic myelin injury is controversial. Glutamate-mediated excitotoxicity is now recognised as a crucial event in the development of ischemic WM pathology. This thesis investigates the potential mechanisms of glutamate release in central WM and examines the hypothesis that NMDA receptor …

    plymouth Repository record

  10. Maximizing Local Access to Therapeutic Deliveries in Glioblastoma: Evaluating the utility and mechanisms of potential adverse events for minimally invasive diagnostic two novel therapeutic techniques for brain tumors

    Kani Kani, Yukitaka SteveVirginia Tech2022

    … explore possible bystander effects of H-FIRE on glutamate metabolism in the brain. H-FIRE has been shown to be able to both ablate brain tumors as well as disrupt the blood-brain barrier (BBB). As these therapeutic effects of H-FIRE are dependent on applying electrical fields to the tissue that …

    vt Repository record

  11. Exploring the Role of PANNEXIN1A in an Acute Experimental Model of Parkinson's Disease

    Zoidl, Georg Stefan Otto2022

    … system Pannexin1 channels are major ATP and glutamate release sites. The channels are implicated in neurodegenerative disorders including Parkinson’s disease, but the underlying mechanisms remain unclear. Here, an interdisciplinary approach tested roles of the mammalian Pannexin1 ortholog …

    york Repository record

  12. Manipulation and characterization of proopiomelanocortin (POMC) neurons in the hypothalamic regulation of energy balance

    Dennison, Christina Suzanne, author, Hentges, Shane T., advisor, Partin, Kathy M., advisor, Pagliassotti, Michael J., committee member, Tamkun, Michael M., committee member, Vigh, Jozsef, committee memberColorado State University. Libraries2015

    … the maintenance of energy balance. POMC neurons release peptide transmitters that modulate pathways involved in food intake, energy expenditure, and reward pathways. POMC peptide release can result in the inhibition of food intake and increased activation of these cells is thought to precipitate …

    colostate Repository record

  13. The mGluR2/3 Agonist LY397268 Improves Morphometric and Behavioral Outcomes in R6/2 Huntington's Disease Mice

    Lafferty, Dennis Craig2016

    … exposure of ionotropic NMDA receptors to glutamate from the cortex can be excitotoxic in HD and leave striatal neurons vulnerable to damage. Activation of presynaptic mGluR2/3 by an agonist dampens glutamate release from corticostriatal terminals. Treatments that target excitoxicity and …

    tenn-hsc Repository record

  14. The role of auditory sensory input during functional pre- and postsynaptic maturation of the calyx of Held synapse

    Erazo-Fischer, Emilio2012

    … affects the in-vivo maturation of a fast glutamatergic CNS synapse, the calyx of Held. To address this question we exploited the distinct presynaptic Ca2+ channel subtypes governing transmitter release at the cochlear inner hair cell (IHC)-spinal neuron synaptic junction compared to those …

    goettingen Repository record

  15. AMPA receptor diversity and dynamics during excitatory synaptic transmission

    Stockwell, ImogenUniversity of Cambridge2025

    … the postsynaptic cell can respond to presynaptic glutamate release with millisecond-timescale precision. The diversity of AMPAR subtypes across the brain is vast, with each subtype providing unique signalling properties. The composition and organisation of AMPARs therefore determines the fidelity …

    cambridge Repository record

  16. Pannexin-1 modulates short-term synaptic plasticity by facilitating endocannabinoid transport

    Bialecki, JenniferGraduate Studies2017

    … postsynaptic localization, ability to release ATP, and coupling to glutamate- sensitive NMDAR receptors make Panx1 a great candidate for altering neurotransmission. As such, this thesis explores the role of Panx1 in synaptic plasticity and its underlying signaling mechanisms. My …

    calgary Repository record

  17. Stress and Hippocampal Plasticity

    Pham, Kara

    … axis and leads to increased glucocorticoid and glutamate release, can inhibit hippocampal neurogenesis, reduce dentate gyrus cell numbers and volume, enhance the expression of PSA-NCAM and transiently increase the synaptic response in the dentate gyrus after perforant path stimulation. …

    rockefeller Repository record

  18. Pre-clinical Targets for Ischemic Brain Injury

    Morgan, Daniel2024

    … has shown that there is extensive vesicular glutamate release during ischemia, causing excitotoxic injury to oligodendrocytes, resulting in demyelination. Glutamate receptor antagonists have been trialled in stroke patients but fall short due to adverse side effects from high dose …

    plymouth Repository record

  19. Effect of metabolic insult on amino acids in the ciliary epithelium, lens, and retina

    Hu, Guo MinResearchSpace@Auckland2007

    … cell resolution. The results showed that a glutamate/glutamine cycle exists between the ciliary epithelium and lens, in analogy to the metabolic relationship between neurons and glia in the retina. with the localisation of glutamine synthetase and glutamate transporters, amino acids …

    auckland-ms Repository record

  20. Molecular Mechanisms Controlling Excitatory Synaptic Transmission

    Watson, Jake FrederickUniversity of Cambridge2019

    … between neurons, neurotransmitter is released from the presynaptic cell and binds to postsynaptic receptors on another. In the case of excitatory synapses, the predominant neurotransmitter, L-glutamate, binds to postsynaptic AMPA receptors (AMPARs). Crucially, synaptic strength is …

    cambridge Repository record

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