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Showing 1 to 20 of 37 for “"glutamate dehydrogenase"”.
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Thermodynamics of Ligand Binding to Glutamate Dehydrogenase
The role of glutamate dehydrogenase (GDH) in disease has been exhibited in congenital hyperinsulinism, specifically, hyperinsulinism/hyperammonemia syndrome (HHS). GDH catalyzes the reversible deamination of glutamate to 2-oxoglutarate. Mutations in GDH can lead to GDH over activity, causing …
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Role and regulation of glutamate dehydrogenase activity in Bacteroides fragilis bf1
… that found in other gram-negative bacteria, with glutamate dehydrogenase (GDH) activity serving as the primary route of ammonia incorporation in both ammonia-limited and ammonia-excess environments. While these studies showed that B. fragilis produces two distinct GDH enzymes, one …
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Comparison of steady state kinetic behaviors of bovine liver and thyroid glutamate dehydrogenase
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Interrogation of the human glutamate dehydrogenase antenna to elucidate its role in allosteric regulation and disease
Glutamate dehydrogenase (GDH) catalyzes the reversible oxidative deamination of L-glutamate using NAD(P)+ as a coenzyme. GDH is found in all living organisms, but only GDH from animals is highly allosterically regulated by a wide array of metabolites. The importance of this regulation is made …
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The NADP-dependent glutamate dehydrogenase of Giardia lamblia: a study of function, gene structure, and expression
… anaerobic metabolism that uses a NADP-dependent glutamatede hydrogenase (GDH) along with alanine aminotransferase to maintain an intracellular balance of NAD(P)+-NAD(P)H through the conversion of pyruvate to alanine. In the initial part of this study, the Giardia NADP-GDH gene was cloned and …
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The Role of Amino Acids in Translocation, and Studies on Glutamate Dehydrogenase, During The Germination of Pumpkin Seeds
Made available in DSpace on 2015-05-14T14:57:09Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7206892.PDF: 3841395 bytes, checksum: 1359db62f7bd1c9ef7d2e73380c974c2 (MD5) Previous issue date: 1971
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Evidence for post-transcriptional regulation of induction of NADP- specific glutamate dehydrogenase by accumulation of its mRNA in uninduced synchronous Chlorella cells
… coding for the ammonium inducible NADP-specific glutamate dehydrogenase (NADP-GDH) from Chlorella was studied in induced and uninduced cells to determine the molecular mechanisms which regulate the cellular levels of this enzyme. A procedure for isolation of a high yield of total undegraded …
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Purification of nicotinamide adenine dinucleotide phosphate- specific glutamate dehydrogenase from Chlorella sorokiniana and partial characterization of its physical, kinetic, and immunological properties
… inducible nicotinamide phosphate-specific glutamate dehydrogenase from Chlorella sorokiniana has been purified 260-fold to homogeneity. Depending on the technique used, the native enzyme appeared to have a molecular mass of 290,000 to 400,000 daltons and to be composed of subunits with an …
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Use of immunological procedures to measure rate of accumulation and degradation of inducible NADP-specific glutamate dehydrogenase during cell cycle of synchronous Chlorella
… adenine dinucleotide phosphate-specific glutamate dehydrogenase from Chlorella sorokiniana. A monospecific, highly purified antibody against the enzyme was prepared from the antisera of immunized rabbits. The antibody was purified on a stable antigen affinity column which was prepared by …
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Studies on the mechanism of gene-regulated synthesis of diphosphopyridine nucleotide- and triphosphopyridine nucleotide-specific glutamate dehydrogenase isozymes during the cell cycle of the eucaryote Chlorella
Two glutamate dehydrogenase isozymes were shown to exist in Chlorella pyrenoidosa (strain 7-11-05) and the cellular level of these isozymes was regulated by the nitrogen source upon which the algae were cultured. One isozyme was induced by ammonium and was specific for the coenzyme, …
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Methodological and biological studies of the amino acid oxidases.
… the reaction being catalysed by exogenous glutamate dehydrogenase L-glutamate: NAL(P) oxidoreductase (deaminating), EC 1.4.1.3.). The inhibition of L-amino acid oxidase (L-amino acid: oxygen oxidoreductase (deaminating), EC 1.4.3.3.) by the ALP needed to activate and stabilise glutamate …
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The Proteomic Response of the Carcinus maenas Y-organ Over the Course of the Molt Cycle
… proteome address the significance of the protein glutamate dehydrogenase. Glutamate dehydrogenase, a key enzyme involved in the formation of glutamate, represents a potential nutrient-sensing checkpoint that might be involved in YO activation. Historically, most attention has gone to the acute …
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Analysis of the ammonium assimilation pathways of the human colonic bacterium, bacteroides thetaiotaomicron
… ammonium through the two primary pathways, the glutamate dehydrogenase (GDH) pathway and the glutamine synthetase/glutamate synthase (GS/GOGAT) pathway. To gain insight into the genomic features underlying ammonium uptake and assimilation in this bacterium, comparative transcriptomic analysis …
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Design and synthesis of novel P. fulciparum GDH inhibitors for use as potential antimalarial agents
… antimalarial drug development targets, Pf-glutamate dehydrogenase (PfGDH). 2) The synthesised compounds were then tested for their antimalarial activity against the P. falciparum strains 3D7 and Dd2. Furthermore, the synthesised compounds were tested against other parasitic organisms, …
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The activity and dynamics of enzymes
… These results, as well as earlier studies on glutamate dehydrogenase, indicate that the observed independence of low temperature activity on global anharmonic picosecondtimescale motion may be a general property of both single- and multi-subunit enzymes. Characterisation of cryosolvent …
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