Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 724 for “"glutamate"”.
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Neuroinflammation, Glutamate Regulation and Memory
Neuroinflammation and excessive glutamatergic signaling have deleterious effects in the brain, are mutually promoting, and play a role in the onset and progression of neurodegenerative diseases. It was my goal to better understand the relationship between neuroinflammation, glutamate dysregulation …
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Glutamate and MDMA Neurobehavioral Toxicity
… concerning the effect of MDMA exposure on the glutamatergic neurotransmitter system. Excitotoxicity resulting from excessive glutamate release has the potential to contribute to the long-term toxicity of MDMA, including neurochemical and behavioral deficits. The purpose of the present study was …
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Structure and function of glutamate transporters
… structural and functional features involved with glutamate transport by the excitatory amino acid transporters (EAAT1-5). This research derives from a study of X-ray crystal structures of an homologous archaeal transporter. Broadly, using computational methods to probe EAAT homology models born …
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Structure and function of glutamate transporters
… structural and functional features involved with glutamate transport by the excitatory amino acid transporters (EAAT1-5). This research derives from a study of X-ray crystal structures of an homologous archaeal transporter. Broadly, using computational methods to probe EAAT homology models born …
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Functional Analysis of Plant Glutamate Receptors
The plant glutamate receptors (GLRs) are homologs of mammalian ionotropic glutamate receptors (iGluRs) and are hypothesized to be potential amino acid sensors in plants. Since their first discovery in 1998, the members of plant GLRs have been implicated in diverse processes such as C/N ratio …
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Thermodynamics of Ligand Binding to Glutamate Dehydrogenase
The role of glutamate dehydrogenase (GDH) in disease has been exhibited in congenital hyperinsulinism, specifically, hyperinsulinism/hyperammonemia syndrome (HHS). GDH catalyzes the reversible deamination of glutamate to 2-oxoglutarate. Mutations in GDH can lead to GDH over activity, causing …
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Glutamate Imaging of Mouse Models of Neurodegeneration
Malfunctions in the glutamatergic system of the central nervous system have been implicated in neurodegenerative diseases such as Alzheimer’s disease (AD), tauopathies, and Parkinson’s disease (PD). A non-invasive measurement of glutamate would enhance our understanding of neurodegenerative …
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Understanding How Sequence Differences Among Glutamate Transporters Might Contribute to their Differential Function in Glutamate Clearance in C. elegans
… clearance of the neurotransmitter. Glutamate-mediated neurotransmission involves the release of glutamate (Glu) into the synaptic cleft by the presynaptic cell and binding to glutamate receptors (GluR) on the postsynaptic cell, leading to activation of a signal transduction cascade. …
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The glutamate hypothesis of depression: the effect of stress and glucocorticoids on glutamate synapse and the action of antidepressants
… and preclinical studies have demonstrated that glutamatergic transmission has a primary role in the pathophysiology of mood and anxiety disorders (MADI). It has been shown that in depressed patients the levels of glutamate and its metabolites are altered in plasma and in selected brain areas and …
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STRUCTURE AND FUNCTION OF A NEURONAL GLUTAMATE TRANSPORTER
<p>Glutamate transporters have a homotrimeric subunit structure with a large central water-filled cavity that extends partially into the plane of the lipid bilayer (Yernool et al., 2004). In addition to uptake of glutamate, the transporters also mediate a chloride conductance that is gated by Na+ …
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STRUCTURE AND FUNCTION OF A NEURONAL GLUTAMATE TRANSPORTER
<p>Glutamate transporters have a homotrimeric subunit structure with a large central water-filled cavity that extends partially into the plane of the lipid bilayer (Yernool et al., 2004). In addition to uptake of glutamate, the transporters also mediate a chloride conductance that is gated by Na+ …
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On the chloride dependence of vesicular glutamate transport
Nervenzellen setzen Neurotransmitter gequantelt frei. Der Neurotransmitter wird dafür in speziellen Organellen, den synaptischen Vesikeln, gespeichert und bei Eintreffen eines Signals in den synaptischen Spalt freigesetzt um die postsynaptische Zelle zu erreichen. Die Aminosäure Glutamat ist der …
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Conformational Changes In The Extracellular Domain of Glutamate Receptors
<p>The family of membrane protein called glutamate receptors play an important role in the central nervous system in mediating signaling between neurons. Glutamate receptors are involved in the elaborate game that nerve cells play with each other in order to control movement, memory, and …
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DESIGN, SYNTHESIS AND CHARACTERIZATION OF ISOXAZOLE CONTAINING GLUTAMATE ANALOGS
Ligands targeting the glutamate binding proteins, both the glutamate receptors and transporters hold a great potential as medicinal agents for a wide variety of neurological disorders. In an attempt to synthesize these ligands, a number of synthetic routes have been explored. Many important …
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DESIGN, SYNTHESIS AND CHARACTERIZATION OF ISOXAZOLE CONTAINING GLUTAMATE ANALOGS
Ligands targeting the glutamate binding proteins, both the glutamate receptors and transporters hold a great potential as medicinal agents for a wide variety of neurological disorders. In an attempt to synthesize these ligands, a number of synthetic routes have been explored. Many important …
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Analyzing A-series gangliosides in neurons following exposure to glutamate
… in rat primary cortical neurons exposed to glutamate toxicity. Primary embryonic (E18) rat cortical neurons were cultured to DIV14. Glutamate toxicity was induced for 1, 3, 6 and 24 h. Immunofluorescence was used to stain for GM1 and GM3 species and ESI-MS was used to quantify the …
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Glutamate Dysregulation in a TauP301L Mouse Model of Alzheimer's Disease
… but recent work suggests tau may mediate glutamatergic signaling. Glutamate is the primary excitatory neurotransmitter in the central nervous system and changes in glutamatergic neurotransmission affect the overall activity of neuronal networks. Although beneficial at low levels, high …
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