Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"glucose-lowering"”.
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Investigation of insulin releasing and glucose lowering effects of extract of selected plants used in African traditional medicinal practice
… of extracts on insulin secretion at various glucose concentrations, in the presence of established modulators of insulin secretion and in the absence of extracellular calcium were also investigated. Cytotoxicity and effects of extracts on cell viability and cell proliferation were assessed in …
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Investigation of cellular mechanisms underlying insulin-releasing or glucose-lowering effects of extracts of selected plants used in traditional medicinal practice for the management of diabetes
… insulin-releasing effects of these extracts were glucose-linked, and data generated strongly suggested the involvement of the KATP-dependent pathway in the actions of these plant extract. Further analyses revealed that all selected extracts enhanced membrane depolarisation and increased …
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Assessing type 2 diabetes associated NeuroCognitive impairment using an e-screening tool in a South African population
… control (HbA1c, disease duration, type of blood glucose lowering treatment) at baseline in a population of people with type 2 diabetes participating in a clinical trial of treatment adherence support using SMS-text messages. Materials and Methods: Sms text Adherence suppoRt for type 2 Diabetes …
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Outcomes and Management of Type 2 Diabetes in India and China
… glycemic deterioration, and responses to oral glucose-lowering drugs. In India, diabetes was associated with double the odds of ischemic heart disease mortality and increased odds of stroke mortality. Medication use was associated with lower odds of ischemic heart disease mortality and stroke …
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Manipulating proglucagon processing in the pancreatic alpha-cell for the treatment of diabetes
… diabetes therapeutic due to its pleotropic blood glucose-lowering effects, including enhancement of glucose-stimulated insulin secretion, inhibition of gastric emptying and glucagon secretion, and promotion of beta-cell survival and proliferation. GLP-1 is produced in the intestinal L-cell via …
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Impacts of Empagliflozin (EMPA) Treatment on Skeletal Muscle Microvasculature in Type 1 Diabetic Rats
… muscle (SM). We investigated whether a blood glucose lowering drug, empagliflozin (EMPA), has any impact on the microvasculature in SM. T1D was induced in eight-week-old male rats using streptozotocin (65 mg/kg, n=21). Twenty-one rats were given daily insulin and 11 of 21 rats also consumed …
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Influence of protein nutrition and exercise on muscle metabolism
… by blunted sensitivity of the pancreas to glucose and impaired glucose uptake in skeletal muscle. Lifestyle interventions including nutrient and exercise have the potential to improve glycemic control. The final experimental chapter in this thesis provides mechanistic evidence to support …
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Glucose metabolism in the critically ill.
… tract is pivotal in the regulation of glucose metabolism in health and diabetes, this relationship had not been explored in the critically ill. The focus of this thesis is glucose metabolism in the critically ill, with a particular emphasis on the role of the gastrointestinal tract in …
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The effects of metformin on the gastrointestinal tract
… is an effective oral agent in normalising blood glucose levels. Metformin is also one of the very few antidiabetic agents that causes modest weight loss in overweight and obese subjects. Despite its introduction into the clinic over 60 years ago, the mechanisms of metformin action are still …
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Glycaemic Response in Relation to Gastric Emptying and Satiety in Health and Disease
… rich in fibre are recommended to control blood glucose levels. Gastric emptying, together with other factors, regulate the postprandial blood glucose response. A delay in the gastric emptying rate (GER) leads to a lower postprandial blood glucose concentration. However, 30-50% of diabetes …
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Investigation of potential intervention targets to improve insulin action: a therapeutic approach
… increase in protein synthesis with facilitated glucose transport, and was independent of the serotonin and noradrenaline reuptake inhibition produced by sibutramine. Pinitol (a methyl inositol) had an insulin mimetic effect and was an effective glucose-lowering agent in insulinopenic states, …
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Assessment and Treatment of Impaired Insulin- Secretion and Action in Type 2 Diabetes
… between individuals with varying degrees of glucose tolerance (Paper I). Both pioglitazone and insulin glargine were effective in reducing HbA1c levels in combination with other oral glucose lowering agents but pioglitazone caused fluid retention and increased levels of natriuretic peptides …
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Pharmacological modulation of insulin resistance - benefits and harms
… Metformin is established as first-line glucose-lowering pharmacotherapy in T2DM. It has also been suggested that it may have benefits in alleviating insulin resistance in type 1 diabetes (T1DM). This thesis examined: (i) cardiovascular, renal and metabolic differences between individuals …
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Controlled Release of Insulin and Modified Insulin from a Novel Injectable Biodegradable Gel
… and water- <br />insoluble zinc salts on blood glucose lowering effect of insulin in type-2 diabetic ZDF rats was investigated. Insulin formulations containing varying concentrations of different water-soluble and water-insoluble zinc salts were prepared and injected subcutaneously in type-2 ZDF …
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Investigation of the metabolic phenotype and metformin response of <i>ATM</i> heterozygous mice
… that tolerate metformin do not respond with glucose lowering. The identification of biomarkers that inform of metformin response in patients is important as it may ensure metformin is prescribed when most effective.<br/><br/>A pharmacogenetic study by Zhou et al. (2011) studied metformin …
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Identification of a Dual-Action Small Molecule with Potent Anti-diabetic and Anti-obesity Activity
… glycemic homeostasis via potentiating glucose stimulated insulin secretion (GSIS) and promoting pancreatic β-cell proliferation and survival. Therefore, targeting L-cells to induce GLP-1 secretion would be an alternative strategy for treating T2D. The goal of this research was to …
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THE ROLE OF HYPOGLYCEMIC AGENTS IN AMELIORATING COGNITIVE FUNCTIONS AND PSYCHIATRIC SYMPTOMS: FROM THE PSYCHIATRIC PATIENT TO EVIDENCE-BASED AND PHARMACOEPIDEMIOLOGIC APPROACHES FOR SUPPORTING THE CLINICAL PRACTICE
Background: Research highlights a complex link between diabetes-related factors such as insulin resistance, hyperglycemia, and chronic inflammation, all contributing to cognitive decline. Schizophrenia and depression, which often co-occur with type 2 diabetes mellitus, show a bidirectional …
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The Impact of Hyperglycemia on Post-Reperfusion Outcomes in Patients with Hyperacute Ischemic Stroke
… from receiving reperfusion therapy nor recommend glucose management during the hyperacute phase of care. While recent studies suggest that mild to moderate hyperglycemia can be safely treated with intravenous insulin, there is insufficient evidence to support that glucose management improves …
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